党永军

党永军,复旦大学医学院生化和分子生物学系研究员。

 

2000-2003年于复旦大学遗传所获博士学位;
2004-2009年约翰霍普金斯大学医学院药理和分子科学系博士后;
2010-2012年约翰霍普金斯大学医学院药理和分子科学系Faculty (Research associate)。
2012年至今复旦大学医学院生化和分子生物学系研究员。

 

主要研究方向:1)天然产物和药物的分子靶点鉴定和作用机制研究;2)以小分子化合物特异性的靶向蛋白用于基础生物学的理论研究;3)建立适于高通量筛选的细胞和动物模型用于新药的筛选和研发。目前共发表SCI收录的文章29篇,分别发表在Mol Cell、PNAS、JBC、RNA、JACS 、Nature Chemical Biology等期刊发表,文章被引超过830次。另获美国授权专利一项。

 

代表论文:
1.Dang Y, Schneider-Poetsch T, Eyler DE, Jewett JC, Bhat S, Rawal VH, Green R, and Liu JO. (2011) Inhibition of Eukaryotic Translation Elongation by the Antitumor Natural Product Mycalamide B. RNA 17(8), 1578-1588  
2.Dang, Y., Low, W.K., Xu, J., Gehring, N.H., Dietz, H.C., Romo, D., and Liu, J.O. (2009). Inhibition of nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII. J Biol Chem 284, 23613-23621. 
3.Dang, Y., Kedersha, N., Low, W.K., Romo, D., Gorospe, M., Kaufman, R., Anderson, P., and Liu, J.O. (2006). Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A. J Biol Chem 281, 32870-32878. 
4.Low, W.K*., Dang, Y*., Schneider-Poetsch, T., Shi, Z., Choi, N.S., Merrick, W.C., Romo, D., and Liu, J.O. (2005). Inhibition of eukaryotic translation initiation by the marine natural product pateamine A. Mol Cell 20, 709-722. *co-first author
(Featured in the review by Dr. Jon Clardy in ACS Chemical Biology “ Stopping Trouble before It starts” 2005 Vol. 1 No. 1 p17; Highlighted in C & EN News “Protein Synthesis Nipped in the Bud” on December 19, 2005; Commented in “Faculty of 1000”)
5.He, H*., Dang, Y*., Dai, F., Guo, Z., Wu, J., She, X., Pei, Y., Chen, Y., Ling, W., Wu, C., et al. (2003). Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. J Biol Chem 278, 29278-29287.  *co-first author
6.Li W, Dang Y, Liu JO, Yu B. (2010). Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity. Bioorg Med Chem Lett. 20(10):3112-5. 
7.Xu J, Dang Y, Ren YR, Liu JO. (2010). Cholesterol trafficking is required for mTOR activation in endothelial cells. Proc Natl Acad Sci U S A. 107(10):4764-9. 
8.Li, W., Dang, Y., Liu, J.O., and Yu, B. (2009). Expeditious Synthesis of Hippuristanol and Congeners with Potent Antiproliferative Activities. Chemistry 15, 10356-10359. 
9.Low, W.K., Dang, Y., Bhat, S., Romo, D., and Liu, J.O. (2007a). Substrate-dependent targeting of eukaryotic translation initiation factor 4A by pateamine A: negation of domain-linker regulation of activity. Chem Biol 14, 715-727. 
10.Low, W.K., Dang, Y., Schneider-Poetsch, T., Shi, Z., Choi, N.S., Rzasa, R.M., Shea, H.A., Li, S., Park, K., Ma, G., et al. (2007b). Isolation and identification of eukaryotic initiation factor 4A as a molecular target for the marine natural product Pateamine A. Methods Enzymol 431, 303-324. 
11.Hu, X., Dang, Y., Tenney, K., Crews, P., Tsai, C.W., Sixt, K.M., Cole, P.A., and Liu, J.O. (2007). Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem Biol 14, 764-774. 
12.Peddibhotla, S., Dang, Y., Liu, J.O., and Romo, D. (2007). Simultaneous arming and structure/activity studies of natural products employing O-H insertions: an expedient and versatile strategy for natural products-based chemical genetics. J Am Chem Soc 129, 12222-12231. 
13.(Highlighted in C&EN News “Tagging Natural Products” on Oct. 1, 2007)
Wu, J., Dang, Y., Su, W., Liu, C., Ma, H., Shan, Y., Pei, Y., Wan, B., Guo, J., and Yu, L. (2006). Molecular cloning and characterization of rat LC3A and LC3B--two novel markers of autophagosome. Biochem Biophys Res Commun 339, 437-442. 
14.Titov DV, Gilman  B, He QL, Bhat S, Low WK, Dang Y, Smeaton M, Demain AJ, Miller PS, Kugel JF, Goodrich JA & Liu JO, (2011) XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nature Chemical Biology 7(3):182-8. Featured as Cover
15.Chamni S, He QL, Dang Y, Bhat S, Liu JO, and Romo D, (2011) Diazo Reagents with Small Steric Footprints for Simultaneous Arming/SAR Studies of Alcohol-Containing Natural Products via O–H Insertion. ACS Chemical Biology 18;6(11):1175-81
16.Schneider-Poetsch T, Ju J, Eyler DE, Dang Y, Bhat S, Merrick WC, Green R, Shen B, Liu JO. (2010). Inhibition of Eukaryotic Translation Elongation via the Ribosomal E-site by Cycloheximide and Lactimidomycin. Nature Chemical Biology 6(3):209-217 (IF=15.808)
17.Liu JO, Titov D, Dang Y, and He QL. (2011) Regulator of Ras Depalmitoylation and Retrograde Trafficking: A New Hat for FKBP. Molecular Cell 21;41(2):131-3 
18.Huang W, Ding L, Huang Q, Hu H, Liu S, Yang X, Hu X, Dang Y, Shen S, Li J, Ji X, Jiang S, Liu JO, Yu L. (2010) Carbonyl reductase 1 as a novel target of (-)-epigallocatechin gallate against hepatocellular carcinoma.  Hepatology 52(2), 703 – 714 
19.Ren, Y.R., Pan, F., Parvez, S., Fleig, A., Chong, C.R., Xu, J., Dang, Y., Zhang, J., Jiang, H., Penner, R., et al. (2008). Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes. PLoS One 3, e4009. 
(Highlighted in Johns Hopkins Gazette on Febrary 16, 2009 “ Old Meds Hold Promise As Therapy for Autoimmune Diseases”)
授权发明专利
“Anticancer agents and use”  United States Patent 7737134

主持项目
自然基金面上项目(2013-2017) 项目批准号:31270830

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