陈舌

陈舌,复旦大学基础医学院生物化学与分子生物学系研究员,博导,上海市细胞生物学会理事。1998年获上海医科大学临床医学学士学位;2003年获复旦大学博士学位;2003-2006年美国纽约州立基础所Research Scientist;2006-2013年美国斯隆-凯特琳癌症中心Research Associate;2013年被复旦大学引进为研究员。迄今已发表SCI论文30余篇,包括Developmental Cell、Science和Nature等期刊,代表性成果:mPar3调节神经细胞极性形成的分子机制;FXR调节肝脏代谢、脂肪肝及肝癌发生发展的分子机制等。获国自然面上基金资助2项。

研究方向:

1、细胞极性与肿瘤

2、代谢性疾病的基因表达调控

3、神经细胞树突发育的分子调控

联系方式:

Email: shechen@fudan.edu.cn

Tel: 021-54237223

代表性论文(*通讯作者):

1.     Dong P, Ma L, Liu L, Zhao G, Zhang S, Dong L, Xue R, Chen S*. CD86+/CD206+, Diametrically Polarized Tumor-Associated Macrophages, Predict Hepatocellular Carcinoma Patient Prognosis Int. J. Mol. Sci. 2016, 17(3), 320.

2.     Wang B, Yang Z, Wang H, Cao Z, Zhao Y, Gong C, Ma L, Wang X, Hu X, Chen S*. MicroRNA-320a inhibits proliferation and invasion of breast cancer cells by targeting RAB11A. Am J Cancer Res. 2015 Aug 15;5(9):2719-29.

3.     Liu X, Zhang XW, Ji LL, Gu JX, Zhou ML, Chen S*. Farnesoid X Receptor associates with         b-catenin and inhibits its activity in hepatocellular carcinoma. Oncotarget. 2015;6(6):4226-38

4.     Ji L, Xue R, Tang W, Wu W, Hu T, Liu X, Peng X, Gu J, Chen S*, Zhang S*. Toll like receptor 2 knock-out attenuates carbon tetrachloride (CCl4)-induced liver fibrosis by downregulating MAPK and NF-κB signaling pathways. FEBS Lett. 2014; 588 (12): 2095-2100

5.    Liu X, Xue R, Ji L, Zhang X, Wu J, Gu J, Zhou M, Chen S*. Activation of farnesoid X receptor (FXR) protects against fructose-induced liver steatosis via inflammatory inhibition and ADRP reduction. Biochem Biophys Res Commun. 2014; 450 (1): 117-123

6.    Chen S*, Chen J, Shi H, Wei M, Castaneda-Castellanos DR, Bultje RS,Pei X, Kriegstein AR, Zhang MJ and Shi SH*. Regulation of microtubule stability and organization by mammalian Par3 in specifying neuronal polarity. Dev Cell 2013;24(1):26-40 (* 并列通讯) (封面文章)

7.    Yu YC*, He SJ*, Chen S, Fu YH, Brown K, Yao XH, Ma J, Gao P, Sosinsky G, Huang K and Shi SH. Preferential electrical coupling regulates lineage-dependent microcircuit assembly in the neocortex. Nature 2012; 2;486(7401):113-7.

8.    Brown K, Chen S, Han Z, Lu CH, Tan X, Ding L, Zhang XJ, Cruz A, Saur D, Anderson S, Huang K, and Shi SH. Clonal Production and Organization of Inhibitory Interneurons in the Neocortex. Science. 2011; 334(6055):480-6.

9.    Chen S, Li B, Grundke-Iqbal I, Iqbal K. I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A. J Biol Chem. 2008 Apr 18;283(16):10513-21

10.  Chen S, Yin X, Zhu X, Yan J, Ji S, Chen C, Cai M, Zhang S, Zong H, Hu Y, Yuan Z, Shen Z, Gu J. The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis. J Biol Chem. 2003;278(22):20029-36.

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