黄海艳

黄海艳(1975~,博士,副教授,硕导。主要研究多潜能干细胞定向分化的分子机制及其在代谢综合征中的作用,揭示多潜能干细胞向前脂肪细胞定向过程中的重要事件及关键蛋白和对代谢过程的影响。迄今,作为第一作者、通讯作者、共同通讯作者发表相关SCI论文10余篇,包括:Proc Natl Acad Sci U S A,Cell Death Differ,Mol Cell Proteomics,J Biol Chem 等杂志。作为项目负责人获国家自然科学基金项目4项。2016年获得教育部自然科学奖二等奖(第3完成人)。

 

代表性论文(*共同通讯作者)

 

1. Chen SZ, Ning LF, Xu X, Jiang WY, Xing C, Jia WP, Chen XL, Tang QQ, Huang HY*. The miR-181d-regulated metalloproteinase Adamts1 enzymatically impairs adipogenesis via ECM remodeling.Cell Death Differ. 2016;23(11):1778-1791.

2. Huang HY*, Zhang WT, Jiang WY, Chen SZ, Liu Y, Ge X, Li X, Dang YJ, Wen B, Liu XH, Lu HJ, Tang QQ.RhoGDIβ Inhibits Bone Morphogenetic Protein 4 (BMP4)-induced Adipocyte Lineage Commitment and Favors Smooth Muscle-like Cell Differentiation. J Biol Chem. 2015 Apr 24; 290(17):11119-29.

3. Chen SZ, Xu X, Ning LF, Jiang WY, Xing C, Tang QQ, Huang HY*. miR-27 impairs the adipogenic lineage commitment via targeting lysyl oxidase. Obesity 2015;23(12), 2445–2453.

4. Huang HY*, Chen SZ, Zhang WT, Wang SS, Liu Y, Li X, Sun X, Li YM, Wen B, Lei QY, Tang QQ. Induction of EMT-like response by BMP4 via up-regulation of lysyl oxidase is required for adipocyte lineage commitment. Stem Cell Res. 2013; 10(3):278-87. doi: 10.1016/j.scr.2012.12.005.

5. Wang SS, Huang HY*, Chen SZ, Li X, Liu Y, Zhang WT, Tang QQ. Early growth response 2 (Egr2) plays opposing roles in committing C3H10T1/2 stem cells to adipocytes and smooth muscle-like cells. Int J Biochem Cell Biol. 2013;45(8):1825-32. doi: 10.1016/j.biocel.2013.06.003.

6. Huang HY, Hu LL, Song TJ, Li X, He Q, Sun X, Li YM, Lu HJ, Yang PY, Tang QQ. Involvement of cytoskeleton-associated proteins in the commitment of C3H10T1/2 pluripotent stem cells to adipocyte lineage induced by BMP2/4. Mol Cell Proteomics. 2011 Jan;10(1):M110.002691. doi: 10.1074/mcp.M110.002691.

7. Huang H, Song TJ, Li X, Hu L, He Q, Liu M, Lane MD, Tang QQ. BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12670-5. doi: 10.1073/pnas.0906266106.

8. He Q, Huang HY*, Zhang YY, Li X, Qian SW, Tang QQ. TAZ is downregulated by dexamethasone during the differentiation of 3T3-L1 preadipocytes. Biochem Biophys Res Commun. 2012 Mar 16;419(3):573-7. doi: 10.1016/j.bbrc.2012.02.074.

9. Huang HY, Li X, Liu M, Song TJ, He Q, Ma CG, Tang QQ. Transcription factor YY1 promotes adipogenesis via inhibiting CHOP-10 expression. Biochem Biophys Res Commun. 2008 Oct 31;375(4):496-500. doi: 10.1016/j.bbrc.2008.07.151.

10. Huang H, Lane MD, Tang QQ. Effect of serum on the down-regulation of CHOP-10 during differentiation of 3T3-L1 preadipocytes. Biochem Biophys Res Commun. 2005 Dec 16;338(2):1185-8. Epub 2005 Oct 21.

 

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