文波

文波,研究员,国家重大科学研究计划首席科学家,全国优秀博士论文获得者,现任复旦大学基础医学院生物化学及分子生物学系副主任(主持工作)。2004年获复旦大学遗传学博士学位;2005年起在美国约翰.霍普金斯大学从事博士后研究,并于2009年晋升为讲师;2010年任复旦大学研究员。在NatureNature Genetics等国际学术期刊上发表论文30余篇,被引用超过5000次。获上海市曙光学者、浦江人才计划资助。

E-MAIL: bowen75@fudan.edu.cn

 

 

研究方向

1、染色质高级结构的功能、分子机制及生理病理意义;

2、以多能干细胞、精子发生为模型研究细胞身份转换的表观遗传机制

 

代表性论文 (#并列第一作者;*通讯作者)

1、Sun Z, Zhu M, Lv P, Cheng L, Wang Q, Tian P, Yan Z, Wen B*. The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway. Stem Cell Reports. 2018. 11(3):741-755.

2、Fan H ,Lv P ,Huo X, Wu J,Wang Q, Cheng L, Liu Y, Tang QQ, Zhang L, Zhang F, Zheng X, Wu H, Wen B*. The nuclear matrix protein HNRNPU maintains 3D genome architecture globally in mouse hepatocytes. Genome Research, 2018. 28(2):192-202

3、Fu Y, Lv P, Yan G, Fan H, Cheng L, Zhang F, Dang Y, Wu H, Wen B*. MacroH2A1 associates with nuclear lamina and maintains chromatin architecture in mouse liver cells. Sci Rep. 2015. 5:17186.

4、Kim K#, Doi A#, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich LI, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, McKinney-Freeman S, Naveiras O, Yoon TJ, Irizarry RA, Jung N, Seita J, Hanna J, Murakami P, Jaenisch R, Weissleder R, Orkin SH, Weissman IL, Feinberg AP, Daley GQ. Epigenetic memory in induced pluripotent stem cells. Nature 2010 16 (7313):285-90

5、Wen B, Wu H, Shinkai Y, Irizarry R and Feinberg AP.  Large histone H3 lysine-9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells. Nature Genetics  2009. 41: 246-50

6、Doi A#, Park IH#, Wen B#, Murakami P, Aryee M, Irizarry R, Herb B, Ladd-Acosta C, Rho J, Loewer S, Miller J, Schlaeger T, Daley GQ and Feinberg AP.  Differential methylation of tissue- and cancer specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nature Genetics 2009 41(12):1350-3.

 7、Wen B#, Wu H#, Bjornsson H, Green RD, Irizarry R, Feinberg AP.  Overlapping euchromatin/heterochromatin- associated marks are enriched in imprinted gene regions and predict allele-specific modification.  Genome Research  2008. 18:1806-13

8、Wen B, Li H, Gao S, Mao X, Gao Y, Li F, Zhang F, He Y, Dong Y, Zhang Y, Huang W, Jin J, Xiao C, Lu D, Chakraborty R, Su B, Deka R, Jin L.  Genetic structure of Hmong-Mien speaking populations in East Asia as revealed by mtDNA lineages.  Molecular Biology and Evolution  2005. 22: 725-34

9、Wen B*, Xie X, Gao S, Li H, Shi H, Song X, Qian T, Xiao C, Jin J, Su B, Lu D, Chakraborty R, Jin L*.  Analyses of genetic structure of Tibeto-Burman populations reveals sex-biased admixture in southern Tibeto-Burmans.  American Journal of Human Genetics  2004. 74: 856-65

10、Wen B, Li H, Lu DR, Song XF, Zhang F, He YG, Li F, Gao Y, Mao XY, Zhang L, Qian J, Tan JZ, Huang W, Deka R, Su B, Chakraborty R, Jin L.   Evidence Supports Demic Diffusion of Han Culture.  Nature  2004. 431: 302-5

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