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Distinguished Young Scholars
Zhenghong Yuan
发表时间:2018-05-02 阅读次数:604次

NAME: Zhenghong Yuan,Ph.D., M.D.
POSITION:Professor
TEL: 021-64161928
E-MAIL: zhyuan@shmu.edu.cn

 

 

RESEARCH INTERESTS
1. The interplay between Innate Immune System and Hepatitis B Virus:from understanding to the development of novel therapeutics for functional cure.
2. Mechanism of replication and pathogenesis of hepatitis C virus

KEY RESEARCH ACHIVEMENT

      Prof. Yuan’s main research areas are the interaction and mechanism of the hepatitis B virus infection with the innate immune system, and the identification of emerging infectious disease pathogen. His representative results include: revealing the new mechanism of impairment of innate immune responses in chronic HBV infection by the hepatitis B virus through the surface antigen and polymerase; proposing the new mechanism of IFN-α inhibiting HBV replication by exosome; discovering the miRNA molecules associated with the early response to interferon treatment; detecting the new human H7N9 avian flu virus infection and its drug-resistant mutation. Since 2009, he has published more than 40 papers in internationally peer-reviewed journals such as NEJM, Lancet, Nat Immunology, HEPATOLOGY, JV, JBC, and JVI and so on. In recent years, he has won the first prize of Natural Sciences Award from Ministry of Education, and the first prize from the Society of Chinese Preventive Medicine.

HONORS AND AWARDS
2017  National Scientific and Technological Progress Special Award
2016  Chinese Society of Preventive Medicine Science and Technology Award,first prize
2015  Ministry of Education Natural Science Award,first prize
2015  Chinese Medical Science and Technology Award,first prize
2013  Chinese Society of Preventive Medicine Science and Technology Award,first prize
2012  Ministry of Education Natural Science Award,first prize
2010  Shanghai Society of Medicine Science and Technology Award,third prize
2009  Ministry of Education Natural Science Award,second prize
2005  Shanghai Scientific and technological Progress Award,third prize
2004  Chinese Medical Science and Technology Award,first prize
2004  Shanghai Medical Science and Technology Award,third prize
2001  Ministry of Education Technological Invention Award,first prize

WORK FOR PROFESSIONAL SOCIETIES (国内外学术团体任职)
2012-2017      Member of High Grade Pathogenic Microorganism Biosafety Review Committee, Ministry of Science and Technology
2014-2016      Chair, Virology Division, Chinese Medical Association
2011-present   Vice chair, Virology Division, Chinese Society for Microbiology
2001-present   Member of Chinese Society for Microbiology
2000- present  Member of Shanghai Society of Medicine

SERVICE TO PROFESSIONAL PUBLICATIONS (编委以上(列出年份),或受邀审稿学术刊物,列出重要杂志名)
2011-present  Associate Editor, Emerging Microbes Infections
2015-2018  Editor,Journal of Clinical Hepatobiliary Diseases   
2017-present Associate Editor, Journal of Chinese Experimental and Clinical Virology

UNIVERSITY SERVICE(Fudan University)
Member of Academic Degrees Committee

INVITED PRESENTATIONS (近5年国内大会报告、国际重要会议专题报告以上)

Year          Title of the presentation Name of the conference Place
2013           HBV and Innate Immunity 23rd Conference of the Asian Pacific Association for the Study of the Liver(APASL) Singapore
2013            HBV and Innate Immunity 2nd Huashan Forum, Shanghai Shanghai
2014           The interplay between HBV and Innate Immunity National symposia on viral infection and Organ failure Beijing
2014           Drug resistance and pathogenesis of H7N9 virus International symposium on clinical and translational medicine Shanghai
2014            New insights into the interaction between HBV and interferon 17th China-Novartis Mini-Symposium Chengdu
2014            Innate Immune response: more important in Chronic Hepatitis B? The Second Central China International Forum on Liver Disease and Infection Wuhan

2014         
Host immune responses in the pathogenesis of HBV infection. APASL Single Topic Conference:4th HBV conference Guangzhou
2015   Role of innate immune response in the pathogenesis of HBV infection 2015 International workshop for therapeutic antibody and antigen-antibody complexes basic and application and First Changjiang forum of infectious diseases & liverdiseases Shanghai
2015           Control of emerging infectious diseases. Sino-Germany Workshop on Infectious Diseases Germany
2015         Novel mechanism of chronic infections of HBV: role of HBsAg. The 11th Annual Meeting of Chinese Socety for Virology and the 6th  Wuhan International Symposium on Modern Virology. Wuhan
2016            Exosome and viruses 2016 symposium of exosome and virus: from experimental to clinical Shanghai
2016            HBV and Interferons Science of HBV cure Singapore
2016            Exosome and HBV infection The 14th national symposia of infectious diseases Qingdao
2016             The roles of innate immunity in HBV persistent infection 2016Beijing-Shanghai symposium on virology Shanghai
2016           Exosomes and Viruses The 4th national symposia on viral infection and Organ failure Chongqing

2017         
Interferon and HBV cure,old soldier,but new development Singapore Hepatology Conference and the Best of EASL (SHC-EASL) 2017 Singapore
2017             Anti-HBV Toward to a Function Cure The 6th national symposia of small interfere RNA and its application(RNAi China 2017) Kunshan
2018            Towards HBV cure 2018 Leading Investigators' Forum on Infectious and Liver Diseases(LIFILD) Shanghai
2018            Management of HBV cccDNA: New Cell Model, Detection, Epigenetic Regulation and Implications for Development of Novel Antiviral Strategies 2018 Forum on Advancements in Immunology Research (FAIR) Shanghai
2018            Novel strategies to eliminate or silence HBV cccDNA The 5th national symposia on viral infection and Organ failure Hangzhou

PEER REVIEWED PUBLICATIONS(以第一或通讯作者发表,通讯作者以“*”标出,从2018年起倒序排列。选不超过10篇代表性论文用黄色高亮标出。)
1.Jielang Chen, Jianhua Li,Xiaonan Zhang, Min Wu,Bisheng Shi,Zhong Fang, Zhenghong Yuan*,Interplay between Hepatitis B Virus and the Type I Interferon System and New Therapeutic Strategies. Fudan Journal (Medical edition)  2017, Vol. 44 Issue (06): 793-798. Review paper.
2.Jin Li, Xiaonan Zhang, Liang Chen, Zhanqing Zhang, Jiming Zhang, Weixia Wang, Min Wu, Bisheng Shi, Xinxin Zhang, Maya Kozlowski, Yunwen Hu &  Zhenghong Yuan*. Circulating miR-210 and miR-22 combined with ALT predict the virological response to interferonalpha therapy of CHB patients. Scientific Reports 2017
3.Shen F, Li Y, Yang Wang, Sozzi V, Revill PA, Liu J, Gao L, Yang G, Lu M, Sutter K, Dittmer U, Chen J*, Yuan Z*. Hepatitis B Virus Sensitivity to Interferon-α in Hepatocytes is More Associated with Cellular Interferon Response than with Viral Genotype Hepatology. 2017 Oct 23. doi: 10.1002/hep.29609
4.Yi Z, Yuan Z*. Hepatitis C Virus-Associated Cancers. Adv Exp Med Biol, 2017, 1018:129-146. Review paper.
5.Jia X, Chen J, Megger DA, Zhang X, Kozlowski M, Zhang L, Fang Z, Li J, Chu Q, Wu M, Li Y, Sitek B, Yuan Z*. Label-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line.Mol Cell Proteomics. 2017 Feb 27. pii: mcp.M116.063503. doi: 10.1074/mcp.M116.063503.
6.Zhang W, Chen J, Wu M, Zhang X, Zhang M, Yue L, Li Y, Liu J, Li B, Shen F, Wang Y, Bai L, Protzer U, Levrero M, Yuan Z*. PRMT5 Restricts Hepatitis B Virus Replication via Epigenetic Repression of cccDNA Transcription and Interference with pgRNA Encapsidation.Hepatology. 2017 Feb 25. doi: 10.1002/hep.29133
7.Cuncun Chen, Min Wu, Wen Zhang, Wei Lu, Min Zhang, Zhanqing Zhang, Xiaonan Zhang & Zhenghong Yuan* MicroRNA-939 restricts Hepatitis B virus by targeting Jmjd3-mediated and C/EBPα-coordinated chromatin remodeling. SCIENTIFIC REPORTS 2016 Oct 25;6:35974. doi: 10.1038/srep35974.
8.Zhigang Yi,a Caiyun Fang,b Jingyi Zou,a Jun Xu,a Wuhui Song,a Xiaoting Du,a Tingting Pan,a Haojie Lu,b Zhenghong Yuan* Affinity Purification of the Hepatitis C Virus Replicase Identifies Valosin-Containing Protein, a Member of the ATPases Associated with Diverse Cellular Activities Family, as an Active Virus Replication Modulator. Journal of Virology. 2016 Oct 14;90(21): 9953-9966.
9.Xiaoting Du, Tingting Pan, Jun Xu, Yang Zhang,Wuhui Song,Zhigang Yi* and Zhenghong Yuan*. Hepatitis C virus replicative double-stranded RNA is a potent interferon inducer that triggers interferon production through MDA5 Journal of General Virology (2016), 97(11):2868-2882
10.In-situ analysis of intrahepatic virological events in chronic HBV infection. Xiaonan Zhang, Wei Lu, Ye Zheng, Weixia Wang, Lu Bai, Liang Chen, Yanling Feng, Zhanqing Zhang, Zhenghong Yuan*. J Clin Invest, 2016 Mar 1;126(3):1079-92. doi: 10.1172/JCI83339.
11.A Pilot Study of MicroRNAs Expression Profile in Serum and HBsAg Particles: Predictors of Therapeutic Vaccine Efficacy in Chronic Hepatitis B Patients. Wang W, Li J, Zhang X, Wen Y, Wang XY, Yuan Z*. Medicine (Baltimore). 2016 Jan;95(2):e2511. doi: 10.1097/MD.0000000000002511.
12.Chen J, Wu M, Wang F, Zhang W, Wang W, Zhang X, Zhang J, Liu Y, Liu Y, Feng Y, Zheng Y, Hu Y, Yuan Z*. Hepatitis B virus spliced variants are associated with an impaired response to interferon therapy. Sci Rep (2015). 2015 Nov 20;5:16459. doi: 10.1038/srep16459.
13.Fang, Z., Li, J., Yu, X., Zhang, D., Ren, G., Shi, B., Wang, C., Kosinska, A. D., Wang, S., Zhou, X., Kozlowski, M., Hu, Y.,Yuan, Z. *. Polarization of Monocytic Myeloid-Derived Suppressor Cells by Hepatitis B Surface Antigen Is Mediated via ERK/IL-6/STAT3 Signaling Feedback and Restrains the Activation of T Cells in Chronic Hepatitis B Virus Infection. J Immunol, doi:10.4049/jimmunol.1501362 (2015).
14.Zhigang Yi, Jieliang Chen, Maya Kozlowski and Zhenghong Yuan*. Innate detection of hepatitis B and C virus and viral inhibition of the response. Cellular Microbiology doi:10.1111/ cmi .12489.
15.Jieliang Chen, MinWu, Kuancheng Liu, Wen Zhang, Yaming Li,Xiaohui Zhou, Lu Bai and Zhenghong Yuan∗ New insights into hepatitis B virus biology and implications for novel antiviral strategies  National Science Review 2: 296–313, 2015 doi: 10.1093 /nsr/ nwv044.
16.Yinghui Liu, Jianhua Li, Jieliang Chen, Yaming Li, Weixia Wang, Xiaoting Du, Wuhui Song, Wen Zhang, Li Lin and Zhenghong Yuan*. Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways. Journal of Virology. 2015 Feb 15;89(4):2287-300. doi: 10.1128/JVI.02760-14.
17.Yu X, Zhang D, Shi B, Ren G, Peng X, Fang Z, Kozlowski M, Zhou X, Zhang X, Wu M, Wang C, Yuan Z*. Oral administered particulate yeast-derived glucan promotes hepatitis B virus clearance in a hydrodynamic injection mouse model.. PLoS One. 2015 Apr 9;10(4):e0123559. doi: 10.1371/journal.pone.0123559. eCollection 2015.
18.Zhang X, Zhang Z, Dai F, Shi B, Chen L, Zhang X, Zang G, Zhang J, Chen X, Qian F, Hu Y, Yuan Z*.Comparison of circulating, hepatocyte specific messenger RNA and microRNA as biomarkers for chronic hepatitis B and C.PLoS One. 2014 Mar 18;9(3):e92112. doi: 10.1371.
19.Chen J, Yuan Z*.Interplay between hepatitis B virus and the innate immune responses: implications for new therapeutic strategies..Virol Sin. 2014 Feb;29(1):17-24. doi: 10.1007/s12250-014-3412-3.
20.Chen, J., W. Zhang, J. Lin, F. Wang, M. Wu, C. Chen, Y. Zheng, X. Peng, J. Li, and Z. Yuan*. An efficient antiviral strategy for targeting hepatitis B virus genome using Transcription Activator-Like Effector Nucleases. Mol Ther. 2014 Feb;22(2):303-11. doi: 10.1038/mt.2013.212.
21.Song, W. H., M. M. Liu, D. W. Zhong, Y. L. Zhu, M. Bosscher, L. Zhou, D. Y. Ye*, and Z. H. Yuan*. 2013. Tetrazole and triazole as bioisosteres of carboxylic acid: discovery of diketo tetrazoles and diketo triazoles as anti-HCV agents. Bioorg Med Chem Lett 23:4528-31.
22.Li, J., K. Liu, Y. Liu, Y. Xu, F. Zhang, H. Yang, J. Liu, T. Pan, J. Chen, M. Wu, X. Zhou, and Z. Yuan*. 2013. Exosomes mediate the cell-to-cell transmission of IFN-alpha-induced antiviral activity. Nat Immunol 14:793-803.
23.Hu, Y., S. Lu, Z. Song, W. Wang, P. Hao, J. Li, X. Zhang, H. L. Yen, B. Shi, T. Li, W. Guan, L. Xu, Y. Liu, S. Wang, D. Tian, Z. Zhu, J. He, K. Huang, H. Chen, L. Zheng, X. Li, J. Ping, B. Kang, X. Xi, L. Zha, Y. Li, Z. Zhang, M. Peiris*, and Z. Yuan*. 2013. Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. Lancet 381:2273-9.
24.Gao, R., B. Cao, Y. Hu, Z. Feng, D. Wang, W. Hu, J. Chen, Z. Jie, H. Qiu, K. Xu, X. Xu, H. Lu, W. Zhu, Z. Gao, N. Xiang, Y. Shen, Z. He, Y. Gu, Z. Zhang, Y. Yang, X. Zhao, L. Zhou, X. Li, S. Zou, Y. Zhang, L. Yang, J. Guo, J. Dong, Q. Li, L. Dong, Y. Zhu, T. Bai, S. Wang, P. Hao, W. Yang, J. Han, H. Yu, D. Li, G. F. Gao, G. Wu, Y. Wang, Z. Yuan*, and Y. Shu*. 2013. Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med 368:1888-97.
25.Wang, S., Z. Chen, C. Hu, F. Qian, Y. Cheng, M. Wu, B. Shi, J. Chen, Y. Hu, and Z. Yuan*. 2013. Hepatitis B virus surface antigen selectively inhibits TLR2 ligand-induced IL-12 production in monocytes/macrophages by interfering with JNK activation. J Immunol 190:5142-51.
26.Zhang, X., Z. Song, B. Qin, L. Chen, Y. Hu*, and Z. Yuan*. 2013. Rupintrivir is a promising candidate for treating severe cases of enterovirus-71 infection: evaluation of antiviral efficacy in a murine infection model. Antiviral Res 97:264-9.
27.Revill, P.*, and Z. Yuan*. 2013. New insights into how HBV manipulates the innate immune response to establish acute and persistent infection. Antivir Ther 18:1-15.
28.Chen, J., M. Wu, X. Zhang, W. Zhang, Z. Zhang, L. Chen, J. He, Y. Zheng, C. Chen, F. Wang, Y. Hu, X. Zhou, C. Wang, Y. Xu, M. Lu, and Z. Yuan*. 2013. Hepatitis B virus polymerase impairs interferon-alpha-induced STA T activation through inhibition of importin-alpha5 and protein kinase C-delta. Hepatology 57:470-82.
29.Bisheng Shi, Guangxu Ren, Yunwen Hu, Sen Wang, Zhanqing Zhang, Zhenghong Yuan*HBsAg Inhibits IFN-a Production in PlasmacytoidDendritic Cells through TNF-a and IL-10 Induction inMonocytes. PLOS ONE. September 2012 | Volume 7 | Issue 9 | e44900
30.Qi-Ying Chen , Ying-Hui Liu ,Jian-Hua Li , Ze-Kun Wang , Jiang-Xia Liu , Zhenghong Yuan* DNA-dependent activator of Interferon-regulatory factors inhibits Hepatitis B virus replication. World J Gastroenterol. 2012 June 14; 18(22): 2850-2858
31.Xiaonan Zhang, Cuncun Chen, Min Wu, Liang Chen, Jiming Zhang, Xinxin Zhang ,Zhanqin Zhang, Jingdi Wu, Jiefei Wang, Xiaorong Chen, Tao Huang,Lixiang Chen, Zhenghong Yuan*Plasma microRNA profile as a predictor of early virological response to interferon treatment in chronic hepatitis B patients. Antiviral Therapy.2012.;17(7):1243-53
32.Shanshan Wang, Xianfang Wu,Tingting Pan, Wuhui Song, YaohuiWang, Fei Zhang, Zhenghong Yuan*.Viperin inhibits Hepatitis C Virus replication 3 by interfering with thebinding of NS5A to host protein h VAP-33. Journal of General Virology  Virology(2012), 93, 83–92.
33. Zekun Wang, Jinjing Ni, Jianhua Li, Bisheng Shi, Yang Xu, and Zhenghong Yuan*. Inhibition of hepatitis B virus replication by cIAP2 involves accelerating the ubiquitin-proteasome-mediated destruction of polymerase. J. Virol. published 24 August 2011, 10.1128/JVI.00879-11
34.Yaohui Wang, Yuchan Wang, Yan Xu, Wenyan Tong, TingTing Pan, Jianhua Li, Shuhui Sun, Junjie Shao, Huanping Ding, Zhenghong Yuan*Hepatitis C virus NS5B delays S-phase progression in humanhepatocyte-derived cells by relocalizing the cyclin-dependent kinase2-interacting protein (CINP), JBC.2011 286: 26603-26615.
35.Zhigang Yi, Tingting Pan, Xianfang Wu, Wuhui Song Shanshan Wang, Yan Xu,Charles M. Rice, Margaret R. MacDonald,* and Zhenghong Yuan1* Hepatitis C Virus Co-Opts Ras-GTPase-Activating Protein-Binding Protein 1 for Its enomeReplication JOURNAL OF VIROLOGY.July 2011, p. 6996–7004
36.Jianhua Li, Yinghui Liu, Zekun Wang, Kuancheng Liu, Yaohui Wang,Jiangxia Liu,Huanping Ding, and Zhenghong Yuan*Subversion of Cellular Autophagy Machinery by Hepatitis B Virus for Viral Envelopment JOURNAL OF VIROLOGY, July 2011, p. 6319–6333
37.Jianhua Li, Shanshan Lin, Qiying Chen, Lu Peng, Jianwei Zhai  Yinghui Liu Zhenghong Yuan * Inhibition of hepatitis Bvirus replication by MyD88 involves accelerated degradation of pregenomic RNA and nuclear retention of preS/S RNAs. Journal of Virology, July 2010, p.6387–6399
38.Lu Peng, Dongyu Liang, Wenyan Tong, Jianhua Li, and Zhenghong Yuan*HCV NS5A Activates the Mammalian Target of Rapamycin (mTOR) Pathway and Contributes to Cell Survival by Disrupting the Interaction between FK506-binding Protein 38 (FKBP38) and mTOR. THE JOURNAL OF BIOLOGICAL CHEMISTRY.July2,2010.285,NO.27,pp. 20870–20881
39.Shiyan Yu,Jieliang Chen, Min Wu, Hui Chenand Yuan Z*Hepatitis B virus polymerase inhibits RIG-I- andToll-like receptor 3-mediated interferon-b inductionin human hepatocytes through interference withinterferon regulatory factor 3 activation anddampening of the interaction between TBK1/IKKeand DDX3. Journal of General Virology (2010), 91, 2080-2090
40.Zhang L, Peng X, Zhang Z, Feng Y, Jia X, Shi Y, Yang H, Zhang Z, Zhang X, Liu L, Yin L, Yuan Z*Subcellular proteome analysis unraveled annexin A2 related to immune liver fibrosis.JCell Biochem. 2010 Mar 11. 110:219–228
41.Bian G, Cheng Y, Wang Z, Hu Y, Zhang X, Wu M, Chen Z, Shi B, Sun S, Shen Y, Chen EJ, Yao X, Wen Y, Yuan Z*Whole recombinant Hansenula polymorpha expressing hepatitis B virus surface antigen (yeast-HBsAg) induces potent HBsAg-specific Th1 and Th2 immune responses..Vaccine. 2010 Dec 10;28(1):187-94
42.Xiao-Nan Zhang, Zhi-Gang Song, Ting Jiang, Bi-Sheng Shi, Yun-Wen Hu, Zheng-Hong Yuan*.Rupintrivir is a promising candidate for treating severe cases of Enterovirus-71 infection. World J Gastroenterol 2010 January 14; 16(2): 201-209
43.Yongfen Xu, Yunwen Hu, Bisheng Shi, Xiaonan Zhang, JiefeiWang, Zhanqing Zhang,Fang Shen, Qin Zhang, Shuhui Sun, Zhenghong Yuan*HBsAg inhibits TLR9-mediated activation and IFN-α production in plasmacytoid dendritic cells..Molecular Immunology 46 (2009) 2640–2646
44.Xuelian Yu, Bisheng Shi, Yan Gong, Xiaonan Zhang, Silan Shen, Fangxing Qi, Shimin Gu, Yunwen Hu, Zhenghong Yuan*A random PCR screening system for the identification of type 1 human herpessimplex virus Journal of Virological Methods 161 (2009) 91–97
45.Yu XL, Cheng YM, Shi BS, Qian FX, Wang FB, Liu XN, Yang HY, Xu QN, Qi TK, Zha LJ, Yuan ZH*, Ghildyal R.Measles virus infection in adults induces production of IL-10 and is associated with increased CD4+ CD25+ regulatory T cells. J Immunology, 2008,181:7356-7366.
46.Zhiao Chen, Yuming Cheng, Yongfen Xu, Jing Liao, Xiaonan Zhang, Yunwen Hu, Qin Zhang, JiefeiWang,FangShen,ZhenghongYuan*Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclearcells of chronic hepatitis B patients..Clinical Immunology,2008.128(3):400-8
47.Zhang X, Hu Y, Yuan Z*Computational analyses of JAK1 kinase domain: subtle changes in the catalytic cleft influence inhibitor specificity. Biochem Biophys Res Commun. 2008 May 23;370(1):72-6.
48.Shanshan Lin, Min Wu, Yang Xu, Wei Xiong, Zhigang Yi , Xiaonan Zhang, Yuan Zhenghong*Inhibition of Hepatitis B virus replication by MyD88 is mediated by nuclear factor-kappaB activation. BBA-Molecular Basis of Disease. 1772 (2007) 1150–1157
49.Min Wu, Yang Xu, Shanshan Lin, Xiaonan Zhang, Li Xiang, and Zhenghong Yuan*HBV polymerase inhibits the interferon-inducible MyD88 promoter by blocking nuclear translocation of Stat1.Journal of General Virology 2007 Dec;88(Pt 12):3260-9.
50.X. Yu, F. Qian, Y. Sheng, Q. Huang, Y. Zhang, Z. Yuan*, R. Ghildyal. Clinical and genetic characterization of measles viruses isolated from adult patients in Shanghai in 2006. J Clin Virol. 2007 Oct;40(2):146-151.
51.Zhigang Yi, Caiyun Fang, Tingting Pan, Pengyuan Yang, Zhenghong Yuan*. Subproteomic study of hepatitisCvirus replicon reveals Ras-GTPase-activating protein binding protein 1 as potential HCV RC component. Biochemical and Biophysical Research Communications,2006: 350: 174–178
52.Xiao-Nan Zhang, Jiang-Xia Liu, Yun-Wen Hu, Hui Chen, Zheng-Hong Yuan*Hyper-activated IRF-1 and STAT1 contribute to enhanced Interferon stimulated gene (ISG) expression by Interferon α and γ co-treatment in human hepatoma cells..Biochimica et Biophysica Acta 1759 (2006) 417–425
53.Wang J, Tong W, Zhang X, Chen L, Yi Z, Pan  T, Hu Y, Xiang L, Yuan Z*.Hepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells. FEBS Lett. 2006 Aug 7;580(18):4392-400
54.Tingting P, Caiyun F, Zhigang Y, Pengyuan Y, Zhenghong Y*.Subproteomic analysis of the cellular proteins associated with the 3' untranslated region of the hepatitis C Virus genome in human liver cells. Biochem   Biophys   Res   Commun. 2006; 347(3): 683-91.
55.Caiyun Fang, Zhigang Yi, Feng Liu, Shuiyun Lan, Jiadong Wang, Haojie Lu, Pengyuan Yang and Zhenghong Yuan*. Proteome analysis of human liver carcinoma Huh7 cells harboring hepatitis C virus subgenomic replicon. Proteomics.2006, 6(2):519-27
56.Wang Z, Xiang L, Shao J, Yuan Z*.The 3' CCACCA sequence of tRNAAla(UGC) is the motif that is important in inducing Th1-like immune response, and this motif can be recognized by Toll-like receptor 3. Clin Vaccine Immunol. 2006 Jul;13(7):733-9.
57.Liu X, Shao J, Xiong W, Yu S, Hu Y, Liu J, Wang X, Xiang L, Yuan Z*.Cellular cIAP2 gene expression associated with anti-HBV activity of TNF-alpha in hepatoblastoma cells. J Interferon Cytokine Res. 2005 Oct;25(10):617-26
58.Liu L, Zhou X, Liu H, Xiang L, Yuan Z*. CpG motif acts as a 'danger signal' and provides a T helper type 1-biased microenvironment for DNA vaccination. Immunology. 2005 Jun;115(2):223-30.
59.Wang H, Shen XT, Ye R, Lan SY, Xiang L, Yuan ZH*Roles of the polypyrimidine tract and 3' noncoding region of hepatitis C virus RNA in the internal ribosome entry site-mediated translation. Arch Virol. 2005 Jun;150(6):1085-99.
60.Gene expression profiles in peripheral blood mononuclear cells of SARS patients. Yu SY, Hu YW, Liu XY, Xiong W, Zhou ZT, Yuan ZH*. World J Gastroenterol. 2005 Aug 28;11(32):5037-43.
61.Zhang XN, Xiong W, Wang JD, Hu YW, Xiang L, Yuan ZH*.siRNA-mediated inhibition of HBV replication and expression. World J Gastroenterol. 2004;10(20):2967-71
62.Wang X, Yuan ZH*, Zheng LJ, Yu F, Xiong W, Liu JX, Hu GX, Li Y Gene expression profiles in an hepatitis B virus transfected hepatoblastoma cell line and differentially regulated gene expression by interferon-alpha.. World J Gastroenterol. 2004 Jun 15;10(12):1740-5.
63.Wei Xiong, Xun Wang, Xiaoying Liu, Li Xiang, Lingjie Zheng, Zhenghong Yuan*. Interferon-inducible MyD88 Protein Inhibits Hepatitis B Virus Replication. Virology 2004, 319:2 :306-314.
64.Xiong W, Wang X, Liu XY, Xiang L, Zheng LJ, Liu JX, Yuan ZH. *Analysis of Gene Expression in Hepatitis B Virus Transfected Cell Line Induced by Interferon. Acta Biochim Biophys Sin. 2003, 35 :12:1053-1060.
65.Ling Liu, Xiaohui Zhou, Zhengong Yuan* Toll-like receptor-9 induced by physical trauma mediates release of cytokines following exposure to CpG motif in mouse skin. Immunology. 2003:110:341-347
66.Shuiyun Lan, Hua Wang, Hong Jiang, Hongxia Mao, Xiaoying Liu, Xiaonan Zhang,Yunwen Hu, Li Xiang, Zhenghong Yuan*.Direct interaction between a-actinin and Hepatitis C virus NS5B. FEBS Letters. 2003,554:3:289-294
67.Zhou X, Zheng L, Liu L, Xiang L, Yuan Z*.Th2 immunity to HBsAg primed by gene gun DNA vaccination can be shifted towards Th1 immunity by co-delivery of CpG motifs-containing ODN. Scandinavian Journal of Immunology. 2003, 58:350-357
68.Hong-Xia Mao, Shui-Yun Lan, Yun-Wen Hu, Li Xiang, Zheng-Hong Yuan*.Establishment of a cell-based assay system for hepatitis C virus serine protease and its primary applications. World Gastroenterol.2003, 9:11:2474-2479

BOOKS EDITED(主编或副主编)
1.Chief editor,《Meta-studies on microbes and infections》, 2013,
2.Chief editor,  《medical microbiology》2016,
3.Chief editor,  《传染病症候群病原体变异研究技术》,2016,

PATENT ISSUED OR PENDING
PATENT ISSUED(授权专利)

1.乙肝表面抗原-抗体复合物在制备对乙肝疫苗无应答或低应答预防制品中的用途。  No.200610082284.9
2.A control of hepatitis B virus persistent infection vaccine Application.     No.ZL200910196983.X
3.NADH脱氢酶黄素蛋白2在制备检测药物中的应用。 No.201010192412.1
4.A plasma microRNA profile and a quantification kit for prediction of outcome of interferon therapy in chronic hepatitis B patients. No.201110041465.8
5.The application of yeast-drived glucan on drug development of hepatitis B virus infection.No.201210189690.0
6.The application of the exosomes from IFN-α-stimulated cells in treatment of hepatitis B and C. Application.No.ZL201310278403.8
 

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