Distinguished Young Scholars
Qiqun Tang
发表时间:2018-05-02 阅读次数:454次

WWW: http://www.------
1.Molecular mechanism underlying development of white and beige adipocyte
2.Pathogenesis of metabolic disorders
1.Clarified the mechanism of commitment from mesenchyma stem cell to preadipocytes, and differentiation from preadipocytes to mature adipocyte.
2.Clarified the mechanism underlying activation of beige adipocyte, especially role of BMP4 and BMP signaling in beige adipocyte development.
3.Defined series of compounds which improved metabolic disorders by activating beige adipocyte.  
  1. “Outstanding Graduate of Shanghai” by Shanghai Department of Advanced  Education.  1990
  2. “ National Education Committee Scholarship” 1991
  3. “Eastern Scholarship” 1991
  4. “Su-Ping Scholarship”                  1992-1995
  5. “ Golden Award for Young Investigator in Shanghai First Scientific Fair” 1994
  6. “ First Class Science & Technology Progress Award of Shanghai” issued by Science & Technology Progress Awards Jury,  Shanghai Municipality. 1994
  7. “First Class Science & Technology Progress Award” issued by the Department of Human Health Service,  P. R. China. 1998
  8. “Second Class National Science & Technology Progress Award” issued by the Scientific Department of P. R. China. 2000
  9. “First Class Award for National Outstanding Teacher in Biology” by Fok Ying Tung Education Foundation 2002
  10. Prize for Life Science Awarded by Meiji Dairy Industry Co. Ltd. 2007
  11. Shanghai Leading Talent Program 2007
  12. Presidential Award of Fudan University 2008
  13. Award for Outstanding Contribution to Shanghai Medical College, Fudan University 2008
  14. The Most Popular Teacher Award by Leo KoGuan, Fudan University 2008
  15. National Candidate of New Century Millions of Talents Program 2009
  16. Tan Jiazhen Life Science Innovation Award 2010
  17. CMB (China Medical Board) Distinguished Professorship Award 2010
  18. Outstanding Teaching Award, Fudan University 2011
  19. Award for Outstanding Contribution to Shanghai Medical School, Fudan University 2011 Excellent Tutor of Graduate Students of Fudan University
  20. The national excellent scientific and technological workers 2012
  21. Science Research Famous Achievement Award in Higher Institution  2015
  22. The Most Popular Teacher Award of Fudan University  2016
  23. Diabetes Research Progress Award of china  2016
2014.8-2018.8  CSBMB, associate-Chairman
2016- metabolism Specialized Committee of CSBMB, Chairman
2015.04-2020.09  Journal of Biological Chemistry, editorial board member
2017.09- Journal of Biological Chemistry, associated editor
2015.04-2020.09  Journal of Biological Chemistry, editorial board member
2017.09- Journal of Biological Chemistry, associated editor
Peer-reviewer for Nature communication,Diabetes,PNAS,JBC,MCB…
Dean of Key Laboratory of Metabolism and Molecular Medicine, the Ministry of Education
2017,BMP4 Cross-talks With Estrogen/ERα Signaling to Regulate Adiposity and Glucose Metabolism in Females,CSH Asia conference……
  1. Wei XB, Guo L, Liu Y, Zhou SR, Liu Y, Dou X, Du SY, Ding M, Peng WQ, Qian SW, Huang HY, Tang QQ*.Synthesis of cytochrome c oxidase 1 (SCO1) inhibits insulin sensitivity by decreasing copper levels in adipocytes. Biochem Biophys Res Commun. 2017 Sep 23;491(3):814-820
  2. Liu Y, Du SY, Ding M, Dou X, Zhang FF, Wu ZY, Qian SW, Zhang W, Tang QQ*, Xu CJ*. The BMP4-Smad Signaling Pathway Regulates Hyperandrogenism Development in a Female Mouse Model. J Biol Chem. 2017 Jun 1
  3. Zhou SR, Guo L, Wang X, Liu Y, Peng WQ, Liu Y, Wei XB, Dou X, Ding M, Lei QY, Qian SW, Li X, Tang QQ*. Acetylation of Cavin-1 Promotes Lipolysis in White Adipose Tissue. Mol Cell Biol. 2017 May 30.
  4. Lu P, Zhang FC, Qian SW, Li X, Cui ZM, Dang YJ, Tang QQ*. Artemisinin derivatives prevent obesity by inducing browning of WAT and enhancing BAT function. Cell Res. 2016 Oct;26(10):1169-1172.
  5. Chen SZ, Ning LF, Xu X, Jiang WY, Xing C, Jia WP, Chen XL, Tang QQ*, Huang HY. The miR-181d-regulated metalloproteinase Adamts1 enzymatically impairs adipogenesis via ECM remodeling. Cell Death Differ. 2016 Nov 1;23(11):1778-1791.
  6. Guo L, Zhou SR, Wei XB, Liu Y, Chang XX, Liu Y, Ge X, Dou X, Huang HY, Qian SW, Li X, Lei QY, Gao X, Tang QQ*. Acetylation of Mitochondrial Trifunctional Protein α-Subunit Enhances Its Stability To Promote Fatty Acid Oxidation and Is Decreased in Nonalcoholic Fatty Liver Disease. Mol Cell Biol. 2016 Sep 26;36(20):2553-67.
  7. Chen SZ, Xu X, Ning LF, Jiang WY, Xing C, Tang QQ, Huang HY*. (2015) miR-27 impairs the adipogenic lineage commitment via targeting lysyl oxidase. Obesity 2015 Dec;23(12):2445-53
  8. Yan Tang, Shu-wen Qian*, Jue Wang, Meng-yuan Wu, Ping Lu, Xi Li, Hai-yan Huang, Liang Guo, Xia Sun, Cong-jian Xu, Qi-qun Tang*,BMP4 mediates the interplay between adipogenesis and angiogenesis during expansion of subcutaneous white adipose tissue. Journal of Molecular Cell Biology
  9. Yang Liu, Xin Ge, Xin Dou, Liang Guo, Yuan Liu, Shui-rong Zhou, Xiang-bo Wei, Shu-wen Qian, Hai-yan Huang, Cong-jian Xu, Wei-Ping Jia, Yong-jun Dang, Xi Li, and Qi-Qun Tang* .(2015)Protein Inhibitor of Activated STAT 1 (PIAS1) Protects Against Obesity-Induced Insulin Resistance by Inhibiting Inflammation Cascade in Adipose Tissue. Diabetes 2015; 64(12): 4061-74
  10. Zhi-Chun Zhang, Yan Liu, Liu-Ling Xiao, Shu-Fen Li, Jing-Hui Jiang, Yue Zhao, Shu-Wen Qian, Qi-Qun Tang, Xi Li* (2015) Up-regulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice. Journal of Hepatology, 2015; 63: 1466-1475
  11. Liu-Ling Xiao, Xu-Guang Yang, Yu-Li Lin, Shu-Fen Li, Jin-Hui Jiang, Shu-Wen Qian, Qi-Qun Tang, Rui He* and Xi Li*,(2015) Large adipocytes function as antigen-presenting cells to activate CD4+ Q1 T cells via upregulating MHCII in obesity. International Journal of Obesity (2015), 1–9
  12. Huang HY*, Zhang WT, Jiang WY, Chen SZ, Liu Y, Ge X, Li X, Dang YJ, Wen B, Liu XH, Lu HJ, Qi-Qun Tang* .(2015) RhoGDIβ Inhibits Bone Morphogenetic Protein 4 (BMP4)-induced Adipocyte Lineage Commitment and Favors Smooth Muscle-like Cell Differentiation. J Biol Chem. 2015 Apr 24;290(17):11119-29
  13. Guo L, Li X, Qi-Qun Tang*.(2015) Transcriptional regulation of adipocyte differentiation: a central role for CCAAT/enhancer-binding protein (C/EBP) β. J Biol Chem. 2015 Jan 9;290(2):755-61
  14. Yan Jiang, Liang Guo, Li-Qi Xie, You-You Zhang, Xiao-Hui Liu, Yang Zhang, Hao Zhu, Peng- Yuan Yang, Hao-Jie Lu, Qi-Qun Tang*. (2014) Proteome profiling of mitotic clonal expansion during 3T3-L1 adipocyte differentiation using iTRAQ-2DLC-MS/MS. J. Proteome Res. 2014 Mar 7;13(3):1307-14.
  15. Zhichun Zhang, Liu, Y.; Shu-Fen Li, Liang Guo, Yue Zhao, Shu-Wen Qian, Bo Wen, Qi-Qun Tang, Xi Li*, (2014) Suv39h1 Mediates AP-2alpha-Dependent Inhibition of C/EBPalpha Expression during Adipogenesis. Mol Cell Biol, 34 (12), 2330-2338
  16. Xi Li, Rong Zeng, Qi-Qun Tang*, (2014) Evaluation of protein phosphorylation during adipogenesis. Methods in Enzymology , 538:279-295
  17. Yue Zhao, Ya-Dong Zhang, You-You Zhang, Shu-Wen Qian, Zhi-Chun Zhang, Shu-Fen Li, Liang Guo, Yuan Liu, Bo Wen, Qun-Ying Lei Qi-Qun Tang, Xi Li*, (2014) p300-Dependent Acetylation of ATF5 Enhances C/EBPβ Transactivation of C/EBPα During 3T3-L1 Differentiation. Mol Cell Biol. 34(3):315-324
  18. Yang Liu, Ya-Dong Zhang, Liang Guo, Hai-Yan Huang, Hao Zhu, Jia-Xin Huang, Yuan Liu, Shui-Rong Zhou, Yong-Jun Dang, Xi Li, Qi-Qun Tang*, Protein Inhibitor of Activated STAT 1 (PIAS1) Is Identified as the SUMO E3 Ligase of CCAAT/Enhancer- Binding Protein β (C/EBPβ) during Adipogenesis. Mol Cell Biol. 2013 Nov;33(22): 4606-17
  19. Liang Guo, Jia-Xin Huang,Yang Liu,Xi Li,Shui-Rong Zhou, Shu-Wen Qian, Yuan Liu, Hao Zhu, Hai-Yan Huang, Yong-Jun Dang, Qi-Qun Tang*,(2013) Transactivation of Atg4b by C/EBPβ promotes autophagy to facilitate adipogenesis. Mol Cell Biol. 33(16):3180-90
  20. Shan-Shan Wang, Hai-Yan Huang, Su-Zhen Chen, Xi Li, Yuan Liu, Wen-Ting Zhang, Qi-Qun Tang* (2013) Early growth response 2 (Egr2) plays opposing roles in committing C3H10T1/2 stem cells to adipocytes and smooth muscle-like cells. Int J Biochem Cell Biol. 45(8):1825-32
  21. Shan-Shan Wang, Hai-Yan Huang, Su-Zhen Chen, Xi Li, Wen-Ting Zhang, Qi-Qun Tang* (2013) Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage FEBS J. 2013Jun; 280(11):2644-51
  22. Shu-fen Li, Liang Guo, Shu-wen Qian, Yuan Liu, You-You Zhang, Zhi-Chun Zhang, Yue Zhao, Jian-Yong Shou, Qi-Qun Tang, Xi Li*,(2013) G9a is transactivated by C/EBPβ to facilitate mitotic clonal expansion during 3T3-L1 preadipocyte differentiation. Am J Physiol Endocrinol Metab, 304(9): E990-998
  23. Yuan Liu, Zhi-Chun Zhang, Shu-Wen Qian, You-you Zhang, Hai-yan Huang, Yan Tang, Liang Guo, Xi Li, and Qi-Qun Tang*, (2013)MicroRNA-140 promotes adipocyte lineage commitment of C3H10T1/2 pluripotent stem cell via targeting Osteopetrosis-associated transmembrane protein 1. J. Biol. Chem. 288(12): 8222-30
  24. Shu-wen Qian, Yan Tang, Xi Li, Yuan Liu, You-you Zhang, Hai-yan Huang, Rui-Dan Xue, Hao-yong Yu, Liang Guo, Hui-di Gao, Yan Liu, Xia Sun, Yi-ming Li, Wei-Ping Jia, Qi-Qun Tang*, (2013) BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc Natl Acad Sci USA. 110(9): E798-807
  25. Hai-Yan Huang, Su-Zhen Chen, Wen-Ting Zhang, Shan-Shan Wang, Yang Liu, Xi Li, Xia Sun, Yi-Ming Li, Bo Wen, Qun-Ying Lei,Qi-Qun Tang*,(2013)Induction of EMT-like response by BMP4 via up-regulation of lysyl oxidase is required for adipocyte lineage commitment. Stem Cell Research. 10(3): 278-287
  26. Liang Guo, Xi Li, Jia-Xin Huang, Hai-Yan Huang, You-You Zhang, Shu-Wen Qian, Hao Zhu, Ya-Dong Zhang, Yang Liu, Yuan Liu, Kan-Kan Wang, Qi-Qun Tang*, (2012) Histone Demethylase Kdm4b Functions as a Co-Factor of C/EBPβ to Promote Mitotic Clonal Expansion During Differentiation of 3T3-L1 Preadipocytes. Cell Death Differ.  19(12): 1917-1927.
  27. Qi-Qun Tang, M. Daniel Lane, (2012) Adipogenesis: From stem cell to adipocyte. Annu Rev Biochem. 81:21.1-21.22.
  28. You-you Zhang, Xi Li, Shu-wen Qian, Liang Guo, Hai-yan Huang, Qun He, Yuan Liu, Chun-Gu Ma, and Qi-Qun Tang*, (2012) Down-regulation of type I runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis. Mol Endocrinol. 26(5): 798-808.
  29. Qun He, Hai-yan Huang, You-you Zhang, Xi Li, Shu-wen Qian, Qi-Qun Tang*, (2012) TAZ is downregulated by dexamethasone during the differentiation of 3T3-L1 preadipocytes. Biochem Biophys Res Commun. 419(3): 573-7.
  30. Yuan-yuan Zhang, Shu-fen Li, Shu-wen Qian, You-you Zhang, Yuan Liu, Qi-Qun Tang, Xi Li, (2012) Phosphorylation prevents C/EBPβ from the calpain-dependent degradation. Biochem Biophys Res Commun. 419(3): 550-5.
  31. You-You Zhang, Xi Li, Shu-Wen Qian, Liang Guo, Hai-Yan Huang, Qun He, Yuan Liu, Chun-Gu Ma, and Qi-Qun Tang*, (2011) Transcriptional activation of histone H4 by C/EBP? during the mitotic clonal expansion of 3T3-L1 adipocyte differentiation. Mol Biol Cell, 22: 2165-74.
  32. Hai-Yan Huang, Ling-Ling Hu, Tan-Jing Song, Xi Li, Qun He, Xia Sun, Yi-Ming Li, Hao-Jie Lu, Peng-Yuan Yang, and Qi-Qun Tang* (2011) Involvement of cytoskeleton-associated proteins in the commitment of C3H10T1/2 pluripotent stem cells to adipocyte lineage induced by BMP2/4. Mol Cell Proteomics 10(1): 1-8.
  33. Shu-wen Qian, Xi Li You-You Zhang, Hai-yan Huang, Yuan Liu, Xia Sun, Qi-Qun Tang*. (2010) Characterization of adipocyte differentiation from human mesenchymal stem cells in bone marrow. BMC Developmental Biology. 10:47.
  34. Haiyan Huang, Tan-Jing Song, Xi Li, Lingling Hu, Qun He, Mei Liu, M. Daniel Lane, Qi-Qun Tang*(2009) The BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage, Proc Natl Acad Sci USA. 106: 12670-5.
  35. Xi Li, Henrik Molina, Haiyan Huang, You-you Zhang, Mei Liu, Shu-wen Qian, Chad Slawson, Wagner B. Dias, Akhilesh Pandey, Gerald W. Hart, M. Daniel Lane, Qi-Qun Tang* (2009) O-linked N-acetylglucosamine modification on C/EBP?? role during adipocyte differentiation, J. Biol. Chem., 284: 19248-19254.
  36. Molina H, Yang Y, Ruch T, Kim JW, Mortensen P, Otto T, Nalli A, Tang QQ, Lane MD, Chaerkady R, Pandey A.(2009)Temporal profiling of the adipocyte proteome during differentiation using a five-plex SILAC based strategy. J Proteome Res. 8(1):48-58.
  37. Hai-Yan Huang, Xi Li, Mei Liu, Tanjing Song, Qun He, Chungu Ma, Qi-Qun Tang* (2008) Transcription factor YY1 promotes adipogenesis via inhibiting CHOP-10 expression. Biochem Biophys Res Commun. 375: 496-500.
  38. Lin Jiang, Naixian Zhang, Wei Mo, Rui Wan, Chungu Ma, Xi Li, Yinliang Gu, Xinying Yang, Qi-Qun Tang, Houyan Song (2008) Rehmannia inhibits adipocyte differentiation and adipogenesis, Biochem Biophys Res Commun. 371(2): 185-190.
  39. Deguo Liu, Honglei Liu, Tanjing Song, Haiyan Huang, Xi Li, Qi-Qun Tang*, (2007) Functional expression of the globular domain of human adiponectin in Pichia pastoris. Biochem Biophys Res Commun. 363(3): 769-775.
  40. Xi Li, Jae-Woo Kim, Mads Gronborg, Henning Urlaub,M Daniel Lane, Qi-Qun Tang, (2007) Role of cdk2 in the Sequential Phosphorylation/activation of C/EBP? during adipocyte differentiation. Proc Natl Acad Sci USA. 104: 11597-602.
  41. Jianyong Liu, Heather Martin, Meir Shamay, Crystal Woodard, Qi-Qun Tang, S. Diane Hayward, (2007) Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiation. J Virol. 81: 4722-4731.
  42. Jae-Woo Kim, Qi-Qun Tang, Xi Li, M Daniel Lane, (2007) DNA binding and transcriptional activation by C/EBP beta: effect of phosphorylation and S-S bond-induced dimerization. Proc Natl Acad Sci USA. 104: 1800-4.
  43. Xi Li, Hai-Yan Huang, Jie-Gen Chen, Lin Jiang, Hong-Lei Liu, De-Guo Liu, Tan-Jing Song, Qun He, Chun-Gu Ma, Duan Ma , Qi-Qun Tang* . (2006) Lactacystin inhibits 3T3-L1 adipocyte differentiation through induction of CHOP-10 expression. Biochem Biophys Res Commun. 350(1): 1-6.
  44. Jie-Gen Chen, Xi Li, Hai-Yan Huang, Hong-Lei Liu, De-Guo Liu, Tan-Jing Song, Chun-Gu Ma, Duan Ma,Hou-Yan Song and Qi-Qun Tang* (2006) Identification of a peroxisome proliferator responsive element (PPRE)-like cis-element in mouse plasminogen activator inhibitor-1 gene promoter . Biochem Biophys Res Commun. 347(3): 821-6.
  45. Haiyan Huang, M. Daniel Lane , Qi-Qun Tang*,. (2005) Effect of serum on  Down-regulation of CHOP-10 during Differentiation of 3T3-L1 Preadipocytes . Biochem Biophys Res Commun. 338 (2): 1185-1188.
  46. Qi-Qun Tang, Gronborg M, Huang H, Kim JW, Otto TC, Pandey A, Lane MD, (2005) Sequential phosphorylation of CCAAT enhancer-binding protein {beta} by MAPK and glycogen synthase kinase 3{beta} is required for adipogenesis.Proc Natl Acad Sci U S A. 102(28): 9766-71.
  47. Lane MD, Qi-Qun Tang, (2005) From multipotent stem cell to adipocyte. Birth Defects Res A Clin Mol Teratol. 73(7):476-477.
  48. Huang GC, Zhang JS, Qi-Qun Tang. (2004) Involvement of C/EBP-alpha gene in in vitro activation of rat hepatic stellate cells. Biochem Biophys Res Commun. 324(4): 1309-18.
  49. Qi-Qun Tang, Otto TC, Lane MD. (2004) Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci U S A. 101(26): 9607-11.
  50. Qi-Qun Tang, Zhang JW, Daniel Lane M. (2004) Sequential gene promoter interactions by C/EBPbeta, C/EBPalpha, and PPARgamma during adipogenesis. Biochem Biophys Res Commun. 318(1): 213-8.
  51. Zhang JW, Qi-Qun Tang, Vinson C, Lane MD. Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci U S A. 2004 Jan 6;101(1): 43-7
  52. Qi-Qun Tang, CO Tamara, and MD Lane. CCAAT/enhancer-binding proteinβ is required for mitotic clonal expansion during adipogenesis. Proc.Natl.Acad. Sci. USA. 2003; 100: 850-855.
  53. Qi-Qun Tang, CO Tamara , and MD Lane. Mitotic clonal expansion: A synchronous process required for adipogenesis. Proc.Natl.Acad. Sci. USA. 2003; 100: 44-49.
  54. Wu FY, Wang SE, Qi-Qun Tang, Fujimuro M, Chiou CJ, Zheng Q, Chen H, Hayward SD, Lane MD, Hayward GS. Cell cycle arrest by Kaposi's sarcoma-associated herpesvirus replication-associated protein is mediated at both the transcriptional and posttranslational levels by binding to CCAAT/enhancer-binding protein alpha and p21 (CIP-1). J Virol. 2003 Aug; 77(16):8893-914.
  55. YW Frederick, Qi-Qun Tang, and S Gary. Hayward. Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus caused P21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-α. Proc.Natl.Acad. Sci. USA. 2002; 99:10683-10688.
  56. Qi-Qun Tang, and MD Lane. Role of C/EBP homologous protein (CHOP-10) in the programmed activation of CCAAT/enhancer-binding protein-β during adipogenesis. Proc.Natl.Acad. Sci. USA. 2000; 97, 12446-12450.
  57. MD Lane, Qi-Qun Tang, and MS Jiang. Role of the CCAAT enhancer binding proteins(C/EBPs) in adipocyte differentiation. Biochem Biophys Res Comnmun. 1999; 266(3):677-83.
  58. Qi-Qun Tang, and MD Lane. Activation and centromeric localization of C/EBP’S during the mitotic clonal expansion of adipocyte differentiation. Genes & Development. 1999; 13(17): 2231-2241.
  59. Qi-Qun Tang, MS Liang and MD Lane. Repressive Effect of Sp1 on the C/EBPαGene Promoer: Role in Adipocyte. Mol. Cell. Biology. 1999; 19(7), 4855-4865.
  60. MD Lane, Qi-Qun Tang, and MS Jiang. The Adipocyte Differentiation Program: Repression/Derepression of C/EBPα Gene .  J. Animal. Science. 1999; 77, (suppl.3), 23-32.
  61. MD Lane, MS Jiang and Qi-Qun Tang. Role of C/EBPαin Adipocyte Differentiation. Proceding of Penningtion Syposium on Nutrition Genetics and Obesity,  Ed. by G, Bray and D. Ryan, LSU Press, Balton Rouge, LA. 1998 pp459-475.
  62. MS Jiang, Qi-Qun Tang, J McLenithan, W Schillinglaw, W Henzel and MD Lane. Depression of the C/EBPαGene During Adipogenesis:Identification of Ap-2α as a Repressor.  Proc. Natl. Acad. Sci. USA, 1998; 95, 3467-3471.
  63. Qi-Qun Tang, MS Jiang, and MD Lane. Repression of Transcription Mediated by Dural Elements in CCAAT/enhancer Binding Protein α Gene.  Proc. Nalt. Acad. Sci. USA. 1997; 94, 13571-13575.
  64. CH Zhan, ZL Wan, WR Chang, JJ Yue, DC Liang, Qi-Qun Tang, YL Gu, XX Zhang, G Xu, YS Zhu, HY Song, Crystallization and preliminary X-ray diffraction studies of recombinant staphylokinase, Acta Cryst. 1996; D52: 564-565.434:640-4.
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