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Distinguished Young Scholars
Yichun Zhu
发表时间:2018-05-02 阅读次数:435次

PERSONAL INFORMATION: 
E-mail: yczhu@shmu.edu.cn
 
RESEARCH INTERESTS:
1.The mechanism and intervention of apoptosis in cardiomyocytes
2.New approaches to regulate angiogenesis in ischemic myocardium
3.The mechanism of hydrogen sulfide in regulating cardiovascular ion channels
4.Active ingredients of herbal medicine and their effects on cardiovascular system
 
MAJOR ACADEMIC ACHIVEMENTS
Main research areas are the regulation of cardiovascular system by bioactive small molecules such as hydrogen sulfide and active ingredients of traditional Chinese medicine and their mechanisms. Over 70 peer-reviewed research papers have been published in journals such as Antioxidants & Redox Signaling and Cardiovascular Research. 15 patents for inventions have been issued. The main academic achievements include basic research on innovative treatment methods for cardiovascular remodeling, discovery of vascular protection effects of hydrogen sulfide in multiple targets, revolutionized the research of hydrogen sulfide from the simple observation of its biological function to revealing the common atomic biology  laws and principles.
 
HONORS:
2013, Young and middle-aged experts with outstanding contributions
2013, Talented scientist in the National Hundred, Thousand and Ten Thousand Talent Project
2012, Talented leading scientists in Shanghai
2009, Outstanding principal investigator by Shanghai Municipal Science and Technology Commission
2003, Meiji dairy life science award
2001, Talented scientists of Program for Trans-Century by Ministry of Education
2000, The seventh session of the Henry Fok Education Foundation Award for young teachers in Colleges and Universities
1998, Talented scientists in “Shu Guang” project by Shanghai Municipal Education Commission
 
RESEARCH AWARDS: 
2013, Third Class Prize of China Medical Science and Technology Award
2010, Second Class Prize of Natural Science Research
2010, Third Class Prize of Shanghai Natural Science Award
2008, Third Class Prize of China Medical Science and Technology Award
2005, Third Class Prize of Shanghai science and Technology Progress Award
2004, Second Class Prize of Natural Science Research
 
ACTIVITIES:
2012-present, Editorial member of Endocrine
2006-2016 Associate Editor of Life Sciences
 
UNIVERSITY SERVICE:
Members of the academic committee in Fudan University
 
INVITED PRESENTATIONS:
  1. 2014 Identification of hydrogen sulfide “receptors” in the receptor tyrosine kinase family and ion channels, Third International Conference on Hydrogen Sulfide in Biology and Medicine (H2S 2014), Kyoto, Japan.
  2. 2014 Identification of the molecular switches and the "receptors" for hydrogen sulfide in angiogenesis, sodium homeostasis and glucose metabolism, International Symposium on Aging and Medicine A Satellite Meeting of ISCTM, Shanghai, China
  3. 2013 Identification of H2S receptors in promotion of angiogenesis, Second European Conference on the Biology of Hydrogen Sulfide, Exeter, England
 
PUBLICATIONS
  1. Tao Beibei, Wang Rui, Sun Chen, Zhu Yichun*. 3-Mercaptopyruvate Sulfurtransferase, Not Cystathionine beta-Synthase Nor Cystathionine gamma-Lyase, Mediates Hypoxia-Induced Migration of Vascular Endothelial Cells. Frontiers in Pharmacoloygy. Volume 8, Article ID 657, SEP 20 2017 IF: 4.261
  2. Li Xing-Hui#, Xue Wen-Long#, Wang Ming-Jie#, Zhou Yu, Zhang Cai-Cai, Sun Chen, Zhu Lei, Liang Kun, Chen Ying, Tao Bei-Bei, Tan Bo, Yu Bo, Zhu Yi-Chun*. H2S regulates endothelial nitric oxide synthase protein stability by promoting microRNA-455-3p expression. Scientific Reports. 7, 44807, 2017. IF: 4.259
  3. Hou Cui-Lan#, Wang Ming-Jie#, Sun Chen, Huang Yong, Jin Sheng, Mu Xue-Pan, Chen Ying, and Zhu Yi-Chun. Protective Effects of Hydrogen Sulfide in the Ageing Kidney. Oxidative Medicine and Cellular Longevity. Volume 2016, Article ID 7570489, 13 pages IF: 4.593
  4. Wang Ming-Jie, Cai Wen-Jie; Zhu Yi-Chun. Hydrogen sulphide in cardiovascular system: A cascade from interaction between sulphur atoms and signalling molecules. Life Sciences. 153: 188-197, MAY 15 2016 IF: 2.936
  5. Liu Huan-Di#, Zhang Ai-Jie#, Xu Jing-Jing, Chen Ying, Zhu Yi-Chun*. H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets. Journal of Hematology & Oncology. 9(1):13. Feb 24 2016. doi: 10.1186/s13045-016-0244-7. IF: 6.350
  6. Zhou Yu#, Li Xing-Hui#, Zhang Cai-Cai#, Wang Ming-Jie, Xue Wen-Long, Wu Dong-Dong, Ma Fen-Fen, Li Wen-Wen, Tao Bei-Bei, Zhu Yi-Chun*. Hydrogen sulfide promotes angiogenesis by downregulating miR-640 via the VEGFR2/mTOR pathway. American Journal of Physiology-Cell Physiology. 310(4): C305-C317, Feb15 2016. IF: 3.602
  7. Li Na#, Wang Ming-Jie#, Jin Sheng, Bai Ya-Dan, Hou Cui-Lan, Ma Fen-Fen, Li Xing-Hui, Zhu Yi-Chun. The H2S donor NaHS changes the expression pattern of H2S-producing enzymes after myocardial infarction. Oxidative Medicine and Cellular Longevity. Article Number: 6492469, doi: 10.1155/2016/6492469, Published: 2016 IF: 4.593
  8. Ma Shan-Feng#, Luo Yan#, Ding Ying-Jiong, Chen Ying, Pu Shi-Xin, Wu Hang-Jing, Wang Zhong-Feng, Tao Bei-Bei, Wang Wen-Wei, Zhu Yi-Chun*. Hydrogen sulfide targets the Cys320/Cys529 motif in Kv4.2 to inhibit the Ito potassium channels in cardiomyocytes and regularizes fatal arrhythmia in myocardial infarction. Antioxidants & Redox Signaling. 23(2): 129-147, July 10 2015. IF: 7.093
  9. Jin Sheng, Pu Shi-Xin, Hou Cui-Lan, Ma Fen-Fen, Li Na, Li Xing-Hui, Tan Bo, Tao Bei-Bei, Wang Ming-Jie, Zhu Yi-Chun*. Cardiac H2S generation is reduced in ageing diabetic mice. Oxidative Medicine and Cellular Longevity. 2015;2015:758358. doi: 10.1155/2015/758358. Epub 2015 May 11. IF: 4.492
  10. Liang Min, Jin Sheng, Wu Dong-Dong, Wang Ming-Jie, Zhu Yi-Chun*. Hydrogen sulfide improves glucose metabolism and prevents hypertrophy in cardiomyocytes. Nitric Oxide-Biology and Chemistry. 46(S1):114-222, APR 30 2015. IF: 3.760
  11. Ge Shun-Na, Zhao Man-Man, Wu Dong-Dong, Chen Ying, Wang Yi, Zhu Jian-Hua, Cai Wen-Jie, Zhu Yi-Zhun, Zhu Yi-Chun*. Hydrogen sulfide targets EGFR Cys797/Cys798 residues to induce Na+/K+-ATPase endocytosis and inhibition in renal tubular epithelial cells and increase sodium excretion in chronic salt-loaded rats. Antioxidants & Redox Signaling. 21(15):2061-2082. Nov 20 2014. IF: 7.407 (Cover)
  12. Tao Bei-Bei, Liu Shu-Yuan, Zhang Cai-Cai, Fu Wei, Cai Wen-Jie, Wang Yi, Shen Qing, Wang Ming-Jie, Chen Ying, Zhang Li-Jia, Zhu Yi-Zhun, and Zhu Yi-Chun*. VEGFR2 functions as an H2S-targeting receptor protein kinase with its novel Cys1045–Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells. Antioxidants & Redox Signaling. 19(5): 448-464. AUG 2013. IF: 7.667 (Cover)
  13. Xue Rong#, Hao Dan-Dan#, Sun Ji-Ping#, Li Wen-Wen, Zhao Man-Man, Li Xing-Hui, Chen Ying, Zhu Jian-Hua, Ding Ying-Jiong, Liu Jun, Zhu Yi-Chun*. Hydrogen sulfide treatment promotes glucose uptake by increasing insulin receptor sensitivity and ameliorates kidney lesions in type 2 diabetes. Antioxidants & Redox Signaling. 19(1): 5-23. JUL 2013 IF: 7.667 (Cover)
  14. Zhang Li-Jia, Tao Bei-Bei, Wang Ming-Jie, Jin Hui-Ming, Zhu Yi-Chun*. PI3K p110α isoform-dependent Rho GTPase Rac1 activation mediates H2S-promoted endothelial cell migration via actin cytoskeleton reorganization. PLoS One. 7(9): e44590. Sep 2012 IF: 3.730
  15. Sun Wei-Hua, Liu Fang, Chen Ying, Zhu Yi-Chun*.Hydrogen sulfide decreases the levels of ROS by inhibiting mitochondrial complex IV and increasing SOD activities in cardiomyocytes under ischemia/reperfusion. Biochemical and Biophysical Research Communications. 421(2):164-169,  MAY 4 2012. IF: 2.406
  16. Liu Jun, Hao Dan-Dan, Zhang Jin-Sheng, Zhu Yi-Chun*. Hydrogen sulphide inhibits cardiomyocyte hypertrophy by up-regulating miR-133a. Biochemical and Biophysical Research Communications. 413(2): 342-347, SEP 23 2011. IF: 2.484
  17. Liu Xia, Lu Lei, Tao Bei-Bei, Zhou Ai-Ling, Zhu Yi-Chun*. Amelioration of glomerulosclerosis with all-trans retinoic acid is linked to decreased plasminogen activator inhibitor-1 and alpha-smooth muscle actin. Acta Pharmacologica Sinica. 32(1): 70-78 Jan 2011. IF: 1.953
  18. Wang MJ, Cai WJ, Zhu YC*. The mechanisms of angiogenesis: a role of hydrogen sulphide (review article). Clinical and Experimental Pharmacology and Physiology. 37(7): 764-771, JUL 2010. IF: 1.960
  19. Yao LL, Huang XW, Wang YG, Cao YX, Zhang CC, Zhu YC*. Hydrogen sulfide protects cardiomyocytes from hypoxia/reoxygenation-induced apoptosis by preventing GSK-3-dependent opening of mPTP. Am J Physiol Heart Circ Physiol. 298(5): H1310-H1319 MAY 2010. IF: 3.881
  20. Wang MJ, Cai WJ, Li N, Ding YJ, Chen Y, Zhu YC*. The hydrogen sulfide donor NaHS promotes Angiogenesis in a rat model of hind limb ischemia. Antioxidants & Redox Signaling. 12(9): 1065-1077 MAY 2010. IF: 8.209 (Cover)
  21. Liu X, Lü L, Tao BB, Zhu YC*. All-trans retinoic acid inhibits the increases in fibronectin and PAI-1 induced by TGF-beta 1 and Ang II in rat mesangial cells. Acta Pharmacologica Sinica. 29(9):1035-41 SEP 2008. IF: 1.676
  22. Sun YG, Cao YX, Wang WW, Ma SF, Yao T, Zhu YC*: Hydrogen sulphide is an inhibitor of L-type calcium channels and mechanical contraction in rat cardiomyocytes. Cardiovascular Research. 79(4): 632-641 SEP 2008. IF: 5.947
  23. Shi Y, Cao YX, Lu N, Yao T, Zhu YC*. Hemodynamic-independent anti-natriuretic effect of urotensin II in spontaneously hypertensive rats. Peptides 29(5): 783-794 May 2008. IF: 2.265
  24. Shi YX, Chen Y, Zhu YZ, Huang GY, Moore PK, Huang SH, Yao T, Zhu YC*. Chronic sodium hydrosulfide treatment decreases medial thickening of intramyocardial coronary arterioles, interstitial fibrosis, and ROS production in spontaneously hypertensive rats. American Journal of Physiology-Heart and Circulatory Physiology 293 (4): H2093-H2100 OCT 2007. IF: 3.973
  25. Cai WJ, Wang MJ, Moore PK, Jin HM, Yao T, Zhu YC*. The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation. Cardiovascular Research. 76 (1): 29-40 Oct 2007. IF: 6.127
  26. Yao LL, Wang YG, Cai WJ, Yao T, Zhu YC*. Survivin mediates the anti-apoptotic effect of delta-opioid receptor stimulation in cardiomyocytes. Journal of Cell Science. 120 (5): 895-907 MAR 1 2007. IF: 6.383
  27. Wang YX, Ding YJ, Zhu YZ, Shi Y, Yao T, Zhu YC*. Role of PKC in the novel synergistic action of urotensin II and angiotensin II and in urotensin II-induced vasoconstriction. American Journal of Physiology-Heart and Circulatory Physiology. 292 (1): H348-H359 JAN 1 2007. IF: 3.973
  28. Zhu YC, Zhu YZ, Moore PK. The role of urotensin II in cardiovascular and renal physiology and diseases. British Journal of Pharmacology. 148 (7): 884-901 AUG 2006. IF: 3.825
  29. Gong H, Wang YX, Zhu YZ, Wang WW, Wang MJ, Yao T, Zhu YC*. Cellular distribution of GPR14 and the positive inotropic role of urotensin II in the myocardium in adult rat. Journal of Applied Physiology. 97 (6): 2228-2235 DEC 2004. IF: 2.824
  30. Zhu YC, Zhu YZ, Lu N, Wang MJ, Wang YX, Yao T. Role of angiotensin AT(1) and AT(2) receptors in cardiac hypertrophy and cardiac remodelling. Clinical and Experimental Pharmacology And Physiology. 30 (12): 911-918 DEC 2003. IF: 1.744
  31. Lu L, Yao T, Zhu YZ, Huang GY, Cao YX, Zhu YC*. Chronic all-trans retinoic acid treatment prevents medial thickening of intramyocardial and intrarenal arteries in spontaneously hypertensive rats. American Journal of Physiology-Heart and Circulatory Physiology. 285 (4): H1370-H1377 OCT 2003. IF: 3.658

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