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Distinguished Young Scholars
Qunying Lei
发表时间:2018-05-02 阅读次数:717次

NAME: Qun-Ying Lei, M.D., Ph.D.
POSITION:Professor

E-MAIL:qlei@fudan.edu.cn

LabWebsite:http://www.cancermetabolism.fudan.edu.cn/

RESEARCH INTERESTS
1.Mechanisms of Sensing and utilizing nutrition and metabolite in cancer cells;
2.Regulation of essential metabolic enzyme in cancer metabolic reprogramming;
3.Tumor metabolism and microenvironment

KEY RESEARCH ACHIVEMENT(重要学术贡献,300字以内)
      Metabolic alteration is an essential hallmark of cancer. Cancer cells preferentially utilize glucose to produce lactate even under normoxia, described decades ago as the Warburg effect. Recent discoveries in cancer genomics directly link dysregulated metabolism to cancer initiation and progression. A yet comprehensive picture of cancer metabolism beyond Warburg effect, which intertwines cancer-intrinsic and -extrinsic characteristics of disordered metabolic network, is emerging. It remains largely unknown how metabolic features are reshaped during tumorigenesis, and conversely, how altered metabolism contributes to cancer development.
      Dr. Lei’s group has approached these questions by exploring the sensing and utilization of different nutrients by cancer cells, identifying keyenzymes implicated in oncogenic alterations of metabolism, and investigating the functional interaction of metabolism with tumour microenviroment, etc., hoping to understand the mechanism underlying metabolic alterations during cancer initiation and progression.


HONORS AND AWARDS
2018     The March 8 Red-Banner Pacesetters, All-China Women's Federation
2016     Excellent March 8 Red-Banner Pacesetters, Shanghai Womens Federation(SWF)
2016     National High-Level Talents Special Support Plan(Ten Thousands of People Plan)
2016     Shanghai Yucai Award
2015     Wuzhou women's basic medical science research innovation
2015     First Prize of “Natural Science Award” by Shanghai Government
2015     Accredited Professor for Cheung Kong Scholar Program
2014     The Youth Science and Technology Leading Talent by the Ministry of Science and Technology
2014     Chief Scientist by the Ministry of Science and Technology (973 Program)
2014     Second Prize of Natural Science Award by the Ministry of Education
2013     Chinese Young Women in Science Awards
2013     Shanghai Outstanding Academic Leader
2012     First Prize of Natural Science Award by the Ministry of Education
2012     National Science Fund for Distinguished Young Scholars
2012     The March 8 Red-Banner Pacesetters, Shanghai Womens Federation(SWF)
2011     Distinguished Life Sciences Award, Shanghai, MENJI Diaries Corp
2011     100 Talents Program of Shanghai Health
2011     “Dawn” Program of Shanghai Education Commission
2009     New Century Talent from the Chinese Ministry of Education
2007     Pujiang Talent from Shanghai Government

WORK FOR PROFESSIONAL SOCIETIES (国内外学术团体任职)
2018 - Pres   Director of Chinese Society for Cell Metabolism, CSCB
2015 - Pres   Associate Director of Chinese Society for Medical Biochemistry and Molecular Biology, CSBMB
2015 - Pres   Associate Director and Secretary General of Shanghai Society for Biochemistry and Molecular Biology
2015 - Pres   Committee of Chinese Union of translational Medicie
2015 - Pres   Committee of Chinese Society for Cell Biology (CSCB)
2014 - Pres   Committee of Chinese Society of Biochemistry and Molecular Biology (CSBMB)

SERVICE TO PROFESSIONAL PUBLICATIONS
2018-Pres     Cell Stress
2016- Pres    Member of Editorial Board of Signal Transduction and Therapy Target
2015- Pres    Member of Editorial Board of Acta Biochim Biophys Sin (Shanghai)
2010- Pres    Member of Editorial Board of Chinese Journal of Biochemistry and Molecular Biology (Chin J Biochem Mol Biol)

UNIVERSITY SERVICE(Fudan University)
2017.11-Pres  Vice Dean, Basic Medical College, Fudan University, China
2015-2016    Chairman, Department of Biochemistry and Molecular Biology, Basic Medical College, Fudan University, China


INVITED PRESENTATIONS( Not include the invited seminars at Universities)
1.2013-04   Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase and is Decreased in Pancreatic Cancer, The 13th academic conference of Chinese Society for Cell Biology ,Wuhan
2.2013-07   Acetylation Control of Cancer Metabolism,SCBA2013,Xian
3.2013-09   PKM2 K305 acetyaltion promotes cancer cell metabolism, Chinese Society of Cell Biology 2013 , Beijing
4.2014-04   Acetylation Control of Cancer Metabolism, The tenth Across the Taiwan Strait Symposium On Cell Biology, Taiwan
5.2014-05   Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth ,Ubiquitin2014 ,Shanghai
6.2014-08   Acetylation Control of Metabolic Enzymes in Cancer ,The 13th academic conference of Chinese Society of Biochemistry and Molecular Biology, Xiamen
7.2014-09   Acetylation Control of Cancer Metabolism ,AACR, Shanghai
8.2015-04   Estrogen Activates TAZ via GPER in Invasive Ductal Breast Carcinoma, Chinese Society of Cell Biology 2015 ,Shenzhen
9.2015-06   Acetylation of MAT IIα Represses Tumor Cell Growth and is Decreased in Human Hepatocellular Cancer,Society of Chinese Bioscientists in America the 15th International Symposium, Taibei
10.2015-09  Acetylation of MAT IIα Represses Tumor Cell Growth and is Decreased in Human Hepatocellular Cancer, The eleventh Across the Taiwan Strait Symposium On Cell Biology, Taiyuan
11.2015-10  Estrogen Activates TAZ via GPER in Invasive Ductal Breast Carcinoma, the 4th International Breast Cancer Stem Cell Symposium, Suzhou
12.2015-11  Protein degradation Controls Cancer Metabolism, The 4th Guangzhou International Symposiun on Oncology, Guangzhou
13.2015-12  Protein degradation Controls Cancer Metabolism, Jinyang International Symposium on oncology, Tainyuan
14.2015-12  Acetylation Control of Cancer Metabolism, International Conference on Metabolic Sciences 2015(ICMS 2015), Shanghai
15.2016-05  Protein Degradation Controls Cancer Metabolism, The Symposium of Weishan Lake on oncology, Jining
16.2016-05  Protein Degradation Controls Cancer Metabolism, The 9th CNHUPO Annual Congress, Xiamen
17.2016-10  Acetylation Control of Lipid Synthesis,  The 13th academic conference of Chinese Society of Biochemistry and Molecular Biology, Hangzhou
18.2017-03  Acetate functions as an epigenetic metabolite to promote lipid synthesisunder hypoxia,The 12th  Across the Taiwan Strait Symposium On Cell Biology, Hualian
19.2017-09  Acetate functions as an epigenetic metabolite to promote lipid synthesisunder hypoxia,China-UK Life Science and Medicine Summit, Beijing
20.2017-09  Acetate Functions as an Epigenetic Metabolite to Promote Lipid Synthesis under Hypoxia,The Second International Epigenomics Conference, Shanghai
21.2017-10  Metabolites Promote Hepatocarcinoma Cancer Development, Cold Spring Harbor Conferences Asia ,Suzhou
22.2018-03  Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer, Cold Spring Harbor Asia, Suzhou
23.2018-03  Acetyaltion Control of Lipid Synthesis, Queenstown Molecular Biology Meetings in Shanghai, 2018
24.2018-04  KRAS Stabilizes BCAT2 to Promote PDAC Initiation through BCAAs Catabolism, Chinese Society of Cell Biology2017, Nanjing

PEER REVIEWED PUBLICATIONS(* indicates as corresponding author)
1.Xia S, Lin R, Jin L, Zhao L, Kang HB, Pan Y, Liu S, Qian G, Qian Z, Konstantakou E, Zhang B, Dong JT,   Chung YR, Abdel-Wahab O, Merghoub T, Zhou L, Kudchadkar RR, Lawson DH, Khoury HJ, Khuri FR, Boise LH, Lonial S, Lee BH, Pollack BP, Arbiser JL, Fan J*, Lei QY*, Chen J*. Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth. Cell Metabolism. 2017, 25(2):358-373.  
Highlights: Nature
2.Zhang Y, Xu YY, Yao CB, Li JT, Zhao XN, Yang HB, Zhang M, Yin M*, Chen J* Lei QY*. (2016). Acetylation targets HSD17B4 for degradation via CMA pathway in response to E1. Autophagy. 2017, 13(3):538-553.
3.Wang YP*,Wang J,Gao X, Xu YY, Cheng JK*, Lei QY*. Arginine Methylation of MDH1 by CARM1 Inhibits Non-canonical Glutamine Metabolism and Suppresses Pancreatic Cancer. Molecular Cell. 2016,64, 673–687.
Highlights: Cancer discovery
4.Gao X, Lin SH,Ren F, Li1 JT, Chen JJ, Yao CB,Yang HB,Jiang SX, Yan GQ, Wang D, Wang Y, Liu Y, Cai Z, Xu YY, Chen J, Yu W, Yang YP*, Lei QY*. Acetate Functions as an Epigenetic Metabolite to Promote Lipid Synthesis under Hypoxia. Nature Commun. 2016 ;7:11960.
5.Zha Z, Han XR, Smith MD, Lei QY*, Guan KL*, Xiong Y*. Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination. Cell Discov. 2016 Apr 26;2:16005.
6.Han XR, Zha Z, Yuan HX, Feng X, Xia YK, Lei QY*, Guan KL*, Xiong Y*. KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation. Oncogene. 2016 Aug 11;35(32):4179-90.
7.Yang, HB., Xu, YY*., Zhao, XN, Zou SW*., Zhang Y., Zhang M., Li JT, Ren F., Wang LY., Lei QY*. Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellularcancer. Nature Commun. 2015;Apr 30;6:6973..
8.Lv XB, Liu CY, Wang Z, Sun YP, Xiong Y*, Lei QY*, Guan KL*. PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction. EMBO Rep. 2015 Aug;16(8):975-85.
9.Zha, ZY., Han, XR., Matthew D. Smith, Liu, Y., Patrick M. Giguère, DraganaKopanja, PradipRaychaudhuri, David P. Siderovski, Guan, KL*., Lei, QY*, and Xiong, Y*. A non- canonical function of Gβ as a subunit of E3 ligase in targeting GRK2 ubiquitylation. Molecular Cell. 2015;58(5): 794-803
10.Zhou, X#., Wang, SY#., Wang, Z., Feng, X., Liu, P., Lv, X-B., Li, F-L., Yu, F-x., Sun,YP., Yuan, HX., Zhu, HG., Xiong,Y*., Lei, QY*., Guan, KL*. Estrogen Activates TAZ via GPER in Invasive Ductal Breast Carcinoma. J Clin Invest. 2015;125(5):2123-35.
11.Xu Y, Li F, Lv L, Li T, Zhou X, Deng CX, Guan KL*, Lei QY*, Xiong Y*. Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase. Cancer Res. 2014 Jul 1;74(13):3630-42.
12.Zhao, D., Mo, Y., Li, MT., Zou,SW., Cheng, ZL., Sun, Y-P., Xiong, Y*., Guan, KL*., Lei, QY*. NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin Invest. 2014;124(12):5453-65.
13.Li T, Liu F, Feng X, Wang Z, Das I, Xu Y, Zhou X, Sun Y, Guan KL, Xiong Y, Lei QY*. Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal. J. Biol. Chem. 2014;289(6):3775-85
14.Lv L, Xu Y, Zhao D, Li F, Wang W, Sasaki N, Jiang Y, Zhou X, Li T, Guan KL*, Lei QY* and Xiong Y*. Mitogenic and oncogenic stimulation of K433 acetylation promote PKM2 protein kinase activity and nuclear localization. Molecular Cell. 2013;52, 340–352. (Cover story in Molecular cell)
Highlights:Nature Review in Cancer and Cancer discovery
15.Lin R, Ren T, Gao X, Zhou X, Li T, Xiong Y, Guan KL, Lei QY*. Acetylation Stabilizes ATP- citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth. Molecular Cell. 2013;51, 506–518.
16.Zhao D, Zou S, Liu Y, Zhou X, Mo Y, Wang P, Xu Y, Dong B, Xiong Y*, Lei QY* and Guan KL*., Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer. Cancer Cell. 2013;23, 464-476.
17.Huang W, Lv X, Liu C, Zha Z, Zhang H, Jiang Y, Xiong Y, Lei QY*, Guan KL*. The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. J Biol Chem. 2012 Jul 27;287(31):26245-53.
18.Zhou X, Li T, Feng X, Hsiang E, Xiong Y, Guan KL, Lei QY*. Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage. Biochem J. 2012; 441(1): 227-36.
19.Lv L, Li D, Zhao D, Lin R, Chu Y,Zhang H, Zha Z, Ying Liu, Li Z, Xu Y, Huang Y, Gang W, Xiong Y, Guan KL, and Lei QY*. Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth. Molecular Cell. 2011;42, 719-730. (Feature article) Highlights:Preview in Molecular Cell, Science Signaling, and Faculty of 1000
20.Liu CY, Lv X, Li T, Xu Y, Zhou X, Zhao S, Xiong Y, Lei QY*, Guan KL*. PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ. J Biol Chem. 2011 Feb 18;286(7):5558-66.
21.Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY*, Guan KL*. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem. 2009 May 15;284(20):13355-62.
22.Lei QY*, Zhang H, Zhao B, Zha ZY, Bai F, Pei XH, Zhao S, Xiong Y*, Guan KL.TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway.Mol Cell Biol. 2008 Apr;28(7):2426-36.
23.Lei Q, Jiao J, Xin L, Chang CJ, Wang S, Gao J, Gleave ME, Witte ON, Liu X, Wu H*. NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. Cancer Cell. 2006 May;9(5):367-78.
24.Ke X#, Lei Q#, James SJ, Kelleher SL, Melnyk S, Jernigan S, Yu X, Wang L, Callaway CW, Gill G, Chan GM, Albertine KH, McKnight RA, Lane RH. Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats. Physiol Genomics. 2006 Mar 13;25(1):16-28. (Co-first Author)
25.Lei QY, Wang LY, Dai ZY, Zha XL. The relationship between PTEN expression and anoikis in human lung carcinoma cell lines. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2002 Jul; 34(4):463-8.

BOOKS EDITED
None

PATENT ISSUED OR PENDING
PATENT ISSUED
None

PATENT PENDING
None

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