杨云龙
发表时间:2017-05-25 阅读次数:4899次

电子邮件

yunlongyang(at)fudan.edu.cn

 

教育经历及职位

2017至今, 复旦大学上海医学院 细胞与遗传医学系,研究员

2017-2017, 瑞典卡罗林斯卡医学院,研究人员

2012-2017, 瑞典卡罗林斯卡医学院,博士后研究员

2009-2011, 瑞典卡罗林斯卡医学院,联合培养博士研究生

2006-2011, 复旦大学上海医学院遗传学专业博士研究生

2002-2006, 同济大学生命科学与技术学院生物技术专业本科生

 

主持基金

2019-2022, 上海高校特聘教授(东方学者),上海市教委

2018-2020, 浦江人才,上海市科委

2018-2020, NSFC面上项目,中国

2017-2018, 引进人才启动基金,复旦大学

2017-2018, The Lars Hierta Memorial Foundation

2016-2017, Ogonfonden

2016-2017, Ruth och Rickard Julins foundation

2015-2017, Tore Nilsons Foundation for Medical Research

2014-2017, Karolinska Institute research foundation

 

发表文章

7篇第一作者文章发表于 Cell MetabNat CommunPNAS等刊物。2011年至今发表文献28篇,影响因子总和270,总引用800余次H指数为15. (https://scholar.google.com/citations?hl=en&user=joh17pwAAAAJ&view_op=list_works&sortby=pubdate)

 

主要研究兴趣为:1、肿瘤血管生物学及其微环境的转化医学研究;2、肿瘤、脂肪相关的代谢研究; 3、肿瘤血管、淋巴管转移不同步骤的分子机制及抗转移策略; 4、正常组织血管微环境及其病理机制的转化医学研究。

 
 
1. Sui W, Li H, Yang Y, Jing X, Xue F, Cheng J, et al. Bladder drug mirabegron exacerbates atherosclerosis through activation of brown fat-mediated lipolysis. Proc Natl Acad Sci U S A. 2019 May 13. pii: 201901655. (IF 9.504)
2. Ali Z, Cui D, Yang Y, Tracey-White D, Vazquez-Rodriguez G, Moosajee M, et al. Synchronized tissue-scale vasculogenesis and ubiquitous lateral sprouting underlie the unique architecture of the choriocapillaris. Dev Biol. 2019 Feb 21. pii: S0012-1606(18)30621-3. (IF 3.262)
3. Andersson P, Yang Y, Hosaka K, Zhang Y, Fischer C, Braun H, et al. Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis. JCI Insight. 2018 Oct 18;3(20). pii: 122375. (IF NA)

4. Iwamoto H, Abe M, Yang Y, Seki T, Nakamura M, Hosaka K, et al. Cancer lipid metabolism confers antiangiogenic drug resistance. Cell Metabolism. 2018 May 25;pii: S1550-4131(18)30312-7 (IF 20.565)

5. Feng X, Classon C, Terán G, Yang Y, Li L, Chan S, et al. Atrophy of skin-draining lymph nodes predisposes for impaired immune responses to secondary infection in mice with chronic intestinal nematode infection. PLoS Pathogens. 2018 May 17;14(5):e1007008. (IF 6.158)

6. Hosaka K, Yang Y, Nakamura M, Andersson P, Yang X, Zhang Y, et al. Dual roles of endothelial FGF-2-FGFR1-PDGF-BB and perivascular FGF-2-FGFR2-PDGFRβ signaling pathways in tumor vascular remodeling. Cell Discovery. 2018 Jan 16;4:3. doi: 10.1038/s41421-017-0002-1. (IF 4.462)

7. Fischer C, Seki T, Lim S, Nakamura M, Andersson P, Yang Y, et al. A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning. Nature Communications. 2017 Dec 12;8(1):2079. (IF 12.353)

8. Nakamura M, Zhang Y, Yang Y, Sonmez C, Zheng W, Huang G, et al. Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production. Proceedings of the National Academy of Sciences of the United States of America. 2017 Nov 7;114(45):E9635-E9644. (IF 9.504)

9. Zhang Y, Sun M, Huang G, Yin L, Lai Q, Yang Y, et al. Maintenance of antiangiogenic and antitumor effects by orally active low-dose capecitabine for long-term cancer therapy. Proceedings of the National Academy of Sciences of the United States of America. 2017 Jun 27;114(26):E5226-E5235. (IF 9.504)

10. Liu C, Zhang Y, Lim S, Hosaka K, Yang Y, Pavlova T, et al. A Zebrafish Model Discovers a Novel Mechanism of Stromal Fibroblast-Mediated Cancer Metastasis. Clinical Cancer Research. 2017 Aug 15;23(16):4769-4779. (IF 10.199)

11. Hosaka K, Yang Y, Seki T, Fischer C, Dubey O, Fredlund E, et al. Pericyte-fibroblast transition promotes tumor growth and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 2016 Sep 20;113(38):E5618-27. (IF 9.504)

12. Yang Y, Zhang Y, Iwamoto H, Hosaka K, Seki T, Nakamura M, et al. Discontinuation of anti-VEGF treatment triggers host VEGF-dependent revascularization-induced metastasis. Nature Communications. 2016 Sep 1;7:12680 (IF 12.353)  

13. Seki T, Hosaka K, Lim S, Honek J, Yang Y, Fischer C, et al. Endothelial PDGF-CC mediates VEGF-dependent paracrine regulation of adipocyte function in beige adipose tissues. Nature Communications. 2016 Aug 5;7:12152 (IF 12.353)

14. Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, et al. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Nature Communications. 2016 May 6;7:11385 (IF 12.353)

15. Zhang Y, Yang Y, Hosaka K, Huang G, Zang J, Chen F, et al. Endocrine vasculatures are preferable targets of an antitumor ineffective low dose of anti-VEGF therapy. Proceedings of the National Academy of Sciences of the United States of America. 2016 Mar 28. pii: 201601649 (IF 9.504)

16. Iwamoto H, Zhang Y, Seki T, Yang Y, Nakamura M, Wang J, et al. PlGF-induced VEGFR1-dependent vascular remodeling determines opposing antitumor effects and drug resistance to Dll4-Notch inhibitors. Science Advances 2015 Apr 10;1(3):e1400244 (IF 11.511)

17. Yang X, Zhang Y, Hosaka K, Andersson P, Wang J, Tholander F, et al. VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients. Proceedings of the National Academy of Sciences of the United States of America 2015 Jun 2;112(22):E2900-9. (IF 9.504)

18. Cao R, Ji H, Yang Y, Cao Y. Collaborative effects between the TNF-a-TNFR1-macrophage axis and the VEGF-C-VEGFR3 signaling in lymphangiogenesis and metastasis. OncoImmunology. 2015 Jan 22;4(3):e989777 (IF 5.503)

19. Ji H, Cao R, Yang Y, Zhang Y, Iwamoto H, Lim S, et al. TNFR1 mediates TNF-a-induced tumour lymphangiogenesis and metastasis by modulating VEGF-C-VEGFR3 signalling. Nature Communications. 2014 Sep 17;5:4944. (IF 12.353)

20. Yang X, Zhang Y, Yang Y, Lim S, Cao Z, Rak J, et al. Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth. Proceedings of the National Academy of Sciences of the United States of America 2013 Aug 20;110(34):13932-7. (IF 9.504)

21. Yang Y, Zhang Y, Cao Z, Wahlberg E, Lanne T, Sun B, et al. Anti-VEGF- and anti-VEGFR- induced vascular alteration in mouse healthy tissues. Proceedings of the National Academy of Sciences of the United States of America 2013 Jul 16;110(29):12018-23. (IF 9.504)

22. Hosaka K, Yang Y, Rouhi P, Jensen L, Xue Y, Lim S, et al. Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis. Nature Communications 2013;4:2129. (IF 12.353)

23. Hedlund EM, Yang X, Zhang Y, Yang Y, Shibuya M, Zhong W, et al. Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs. Proceedings of the National Academy of Sciences of the United States of America 2013;110(2):654-659. (IF 9.504)

24. Yang Y, Lin Y, Yue Z, Xinghua G, Fang F, Aijun S, et al. Taurine detected by HRMAS 1H NMR: a potential indicator of early myocardial infarction. Experimental and Therapeutic Medicine 2013;5(3):683-688. (IF 1.410)

25. Xue Y, Lim S, Yang Y, Wang Z, Jensen LD, Hedlund EM, et al. PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells. Nature Medicine 2012;18(1):100-110. (IF 32.621)

26. Jensen LD, Cao Z, Nakamura M, Yang Y, Brautigam L, Andersson P, et al. Opposing effects of circadian clock genes bmal1 and period2 in regulation of VEGF-dependent angiogenesis in developing zebrafish. Cell Reports 2012;2(2):231-241. (IF 8.032)

27. Yang L, Guo W, Zhang Q, Li H, Liu X, Yang Y, et al. Crosstalk between Raf/MEK/ERK and PI3K/AKT in suppression of Bax conformational change by Grp75 under glucose deprivation conditions. Journal of Molecular Biology 2011;414(5):654-666. (IF 4.894)

28. Cao R, Lim S, Ji H, Zhang Y, Yang Y, Honek J, et al. Mouse corneal lymphangiogenesis model. Nature Protocols 2011;6(6):817-826 (IF 12.423)

 

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