王勇波
发表时间:2013-12-06 阅读次数:7302次

姓名: 王勇波(副教授)
Emailwangyongbo@fudan.edu.cn

教育背景:
2009-2012    德国马克斯-德尔布吕克分子医学中心 (Max-Delbrück Center for Molecular Medicine)、柏林自由大学 (Free University of Berlin) 生物学系    博士
2006-2008    上海交通大学药学院药剂学    硕士
2001-2005    上海交通大学药学院    学士

工作经历:
2013-    复旦大学医学院细胞与遗传学系    青年副研究员、副教授
2012-2013    德国马克斯-德尔布吕克分子医学中心    博士后

学术兼职:
中华医学会医学细胞生物学分会青年委员会委员

研究方向:RNA剪接调控与疾病
运用高通量组学技术 (CLIP-Seq, RNA-Seq etc.) 与生物化学、分子生物学等手段,从细胞、动物模型及临床样本多层面系统研究:1、疾病相关剪接因子的作用机制;2、剪接异常在肿瘤中的功能、机制及临床意义;3、基于RNA疾病新分子标记物及治疗策略开发。主要研究成果以通讯作者或第一作者发表在Nucleic Acids Research, EMBO Molecular Medicine, Genome Research等上,累计引用超过290次,其中单篇最高引用114次。

发表论文:
1. Yue Sun, Yufang Bao, Wenjian Han, Fan Song, Xianfeng Shen, Jiawei Zhao, Ji Zuo, David Saffen, Wei Chen, Zefeng Wang, Xintian You*, Yongbo Wang*. Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay. Nucleic Acids Research2017, 45 (14): 8524–8540. (IF10.161)
2. Jiawei Zhao#, Yue Sun#, Yin Huang, Fan Song, Zengshu Huang, Yufang Bao, Ji Zuo, David Saffen, Zhen Shao, Wen Liu*, Yongbo Wang*. Functional analysis reveals that RBM10 mutations contribute to lung adenocarcinoma pathogenesis by deregulating splicing. Scientific Reports, 2017, 7:40488. (IF4.259)
3. Yingying Hu, Ling Yang, Yujie Yang, Yanyan Han, Yongbo Wang, Wen Liu, Ji Zuo. Oncogenic role of mortalin contributes to ovarian tumorigenesis by activating the MAPK–ERK pathway. Journal of Cellular and Molecular Medicine, 2016, 20(11): 2111-2121. IF: 4.499
4. Yongbo Wang#, Andreas Gogol-Döring#, Hao Hu, Sebastian Fröhler, Yunxia Ma, Marvin Jens, Jonas Maaskola, Yasuhiro Murakawa, Claudia Quedenau, Markus Landthaler, Vera Kalscheuer, Dagmar Wieczorek, Yang Wang, Yuhui Hu*, and Wei Chen*. Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation. EMBO Molecular Medicine, 2013, 5: 1431-1442. (IF9.249)
5. Elisa Rodríguez-Seguel, Nancy Mah, Heike Naumann, Igor M. Pongrac, Nuria Cerdá-Esteban, Jean-Fred Fontaine, Yongbo Wang, Wei Chen, Miguel A. Andrade-Navarro, and Francesca M. Spagnoli*. Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergenceGenes & Development. 2013, 27 (17):  1932-1946. (IF: 9.413)
6. Pinar Onal, Dominic Grun, Catherine Adamidi, Agnieszka Rybak, Jordi Solana, Guido Mastrobuoni, Yongbo Wang, Hans-Peter Rahn, Wei Chen, Stefan Kempa, Ulrike Ziebold, and Nikolaus Rajewsky*. Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cellsEMBO Journal. 2012, 31 (12):  2755-2769. (IF: 9.792)
7. Catherine Adamidi#Yongbo Wang#, Dominic Gruen#, Guido Mastrobuoni#, Xintian You#, Dominic Tolle, Matthias Dodt, Sebastian D. Mackowiak, Andreas Gogol-Doering, Pinar Oenal, Agnieszka Rybak, Eric Ross, Alejandro Sánchez  Alvarado, Stefan Kempa*, Christoph Dieterich*, Nikolaus Rajewsky*, and Wei Chen*. De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics. Genome Research. 2011, 21: 1193-1200. (co-first author, IF11.922)

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