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       复旦大学基础医学院前身为上海第一医学院基础医学部,建于1955年4月。1992年12月基础医学部更名为基础医学院。2000年4月,上海医科大学和复旦大...

代表性论文

  1. Wu YE, Enoki R*, Oda Y, Huang ZL*, Honma K, Honma S. Ultradian Calcium Rhythms in the Paraventricular Nucleus and Subparaventricular Zone in the Hypothalamus. Proc Natl Acad Sci U S A. 2018 Sep 18. pii: 201804300. doi: 10.1073/pnas.1804300115.
  2. Wang TX#, Xiong B#, Xu W, Wei HW, Qu WM, Hong ZY, Huang ZL*. Activation of Parabrachial Nucleus Glutamatergic Neurons Accelerates Reanimation from Sevoflurane Anesthesia in Mice. Anesthesiology, 2018, in press.
  3. Luo YJ#, Li YD#, Wang L#, Yang SR, Yuan XS, Wang J, Cherasse Y, Lazarus M, Chen JF, Qu WM, and Huang ZL*. Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D1 receptors. Nature Communications, 2018 Apr 20;9(1):1576. doi: 10.1038/s41467-018-03889-3.
  4. Yang SR*, Hu ZZ, Luo YJ, Zhao YN, Sun HX, Yin D, Wang CY, Yan YD, Wang DY, Yuan XS, Ye CB, Guo W, Qu WM, Cherasse Y, Lazarus M, Ding YQ, Huang ZL*. The rostromedial tegmental nucleus is essential for non-rapid eye movement sleep. PLoS Biology, 2018 Apr 13;16(4):e2002909. doi: 10.1371/journal.pbio.2002909.
  5. Yuan XS#, Wang L#, Dong H#, Qu WM, Yang SY, Cherasse Y, Lazarus M, Schifmann S, de Kerchove d'Exaerde A, Li RX* and Huang ZL*. Striatal adenosine A2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus. eLife, 2017 Oct 12;6. pii: e29055. doi: 10.7554/eLife.29055.
  6. Fang T, Dong H, Xu XH, Yuan XS, Chen ZK, Chen JF, Qu WM* and Huang ZL*, Adenosine A2A receptor mediates hypnotic effects of ethanol in mice. Sci Rep, 2017 Oct 4;7(1):12678. doi: 10.1038/s41598-017-12689-6.
  7. Oishi Y#, Xu Q#, Wang L#, Zhang BJ, Takahashi K, Takata Y, Luo YJ, Cherasse Y, Schifmann S, de Kerchove d'Exaerde A, Urade Y, Qu WM, Huang ZL* and Lazarus M*. Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice. Nat Commun, 2017 Sep 29;8(1):734. doi: 10.1038/s41467-017-00781-4.
  8. Zhang Z # , Wang HJ # , Wang DR, Qu WM* and Huang ZL*. Red light at intensities above 10 lx alters sleep-wake behavior in mice. Light: Science & Applications, 2017, 6, e16231.
  9. Wang YQ, Li R, Wang DR, Cherasse Y, Zheng MQ, Lavielle O, McEown K, Schifmann S, de Kerchove d'Exaerde A, Qu WM, Lazarus M, and Huang ZL*. Adenosine A 2A receptors in the olfactory bulb suppress rapid eye movement sleep in rodents. Brain Struct Funct, 2017 Apr;222(3):1351-1366.
  10. Liu Z, Wu X, Luo YJ, Wang L, Qu WM, Li SQ*, and Huang ZL*. Signaling mechanism underlying the histamine-modulated action of hypoglossal motoneurons. J Neurochem, 2016 Apr;137(2):277-86.
  11. Chen L, Yin D, Wang TX, Guo W, Dong H, Xu Q, Luo YJ, Cherasse Y, Lazarus M, Qiu ZL, Lu J, Qu WM*, and Huang ZL*. Basal forebrain cholinergic neurons primarily contribute to inhibition of electroencephalogram delta activity, rather than inducing behavioral wakefulness in mice. Neuropsychopharmacology, 2016 Jul;41(8):2133-46.
  12. Chen CR, Sun Y, Luo YJ, Zhao X, Chen JF, Yanagawa Y, Qu WM, and Huang ZL*. Paeoniflorin promotes non-rapid eye movement sleep via adenosine A 1 receptors. J Pharmacol Exp Ther, 2016, 356:64–73.
  13. Yin D, Liu YY, Wang TX, Hu ZZ, Chen JF, Qu WM, Cheng NN, and Huang ZL*. Paeoniflorin exerts analgesic and hypnotic effects via adenosine A 1 receptors in a mouse neuropathic pain model. Psychopharmacology, 2016, 233(2):281-93.
  14. Huang ZL*, Zhang Z, Qu WM*. Roles of Adenosine and Its Receptors in Sleep-Wake Regulation. Int Rev Neurobiol. 2014, 119C:349-371.
  15. Zhang GH§, Liu ZL§, Zhang BJ; Geng WY, Song NN, Zhou W, Cao YX, Li SQ, Huang ZL*, Shen LL*, Orexin A activates hypoglossal motoneurons and enhanced genioglossus muscle activity in rats. Br J Pharmacol. 2014, 171:4233–4246.
  16. Cho S, Yoon M, Pae AN, Jin YH, Cho NC, Takata Y, Urade Y, Kim S, Kim JS, Yang H, Kim J; Kim J, Han, JK, Shimizu M, Huang ZL*. Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor. Psychopharmacology (Berl). 2014; 231:2825-2837.
  17. Liu YY§, Yin D§, Chen L, Qu WM, Laudon M, Cheng NN, Urade Y, Huang ZL*, Antinociceptive and hypnotic effects of piromelatine in a mouse model of neuropathic pain. Psychopharmacology, 2014; 231(20):3973-3985.
  18. Han Y, Shi YF, Xi W, Zhou R, Tan ZB, Wang H, Li XM, Chen Z, Feng G, Luo M, Huang ZL, Duan S, Yu YQ, Selective Activation of Cholinergic Basal Forebrain Neurons Induces Immediate Sleep wake Transitions. Curr Biol, 2014;24(6):693-8.
  19. Xu XH, Qiu MH, Dong H, Qu WM*, Urade Y, Huang ZL*, GABA transporter-1 inhibitor NO-711 alters the EEG power spectra and increases non-rapid eye movement sleep during the active phase in mice. Eur Neuropsychopharmacol, 2014; 24, 585–594.
  20. Wang Q, Yue XF, Qu WM*, Tan R, Zheng P, Urade Y and Huang ZL*, Morphine inhibits sleep-promoting neurons in the ventrolateral preoptic area via mu receptors and induces wakefulness in rats, Neuropsychopharmacology, 2013; 38(5):791-801.
  21. Lazarus M, Chen JF, Urade Y, and Huang ZL*, Role of the basal ganglia in the control of sleep and wakefulness. Curr Opin Neurobiol, 2013;23(5):780-785.
  22. Liu YY, Liu TY, Qu WM, Hong ZY, Urade Y and Huang ZL*, Dopamine is involved in food-anticipatory activity in mice, J Biol Rhythms, 2012, 27(5): 398- 409.
  23. Lazarus M, Huang ZL, Lu J, Urade Y, Chen JF. How do the basal ganglia regulate sleep-wake behavior? Trends Neurosci, 2012, 35: 723-732.
  24. Chen CR, Zhou XZ, Luo YJ, Huang ZL*, Urade Y, Qu WM*, Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABAA receptor in mice. Neuropharmacology, 2012, 63: 1191-1199.
  25. Qu WM, Yue XF, Sun Y, Fan K, Chen CR, Hou YP, Urade Y and Huang ZL*, Honokiol promotes non-rapid eye movement sleep via the benzodiazepine site of the GABAA receptor in mice. Br J Pharmacol, 2012, Oct;167(3): 587-598.
  26. Liu Z, Xu XH, Liu TY, Hong ZY, Urade Y, Huang ZL*, and Qu WM*, Safranal enhances non-rapid eye movement sleep in pentobarbital-treated mice, CNS Neurosci Ther,  2012 Aug; 18(8):623-630.
  27. Zhao X, Xu Y, Zhao Q, Chen CR, Liu AM, and Huang ZL*, Curcumin exerts antinociceptive effects in a mouse model of neuropathic pain: descending monoamine system and opioid receptors are differentially involved, Neuropharmacology, 2012, 62: 843-854.
  28. Wang YQ, Tu ZC, Xu XY, Qu WM*, Urade Y, and Huang ZL*, Acute administration of fluoxetine normalizes rapid eye movement sleep abnormality, but not depressive behaviors in olfactory bulbectomized rats. J Neurochem, 2012,120:314-324.
  29. Chen CR, Tan R, Qu WM, Wu Z, Wang Y, Urade Y, Huang ZL*. Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts anti-epileptic effects via GABA- benzodiazepine receptor complex in mice, Br J Pharmacol, 2011, 164(5):1534-46.
  30. Huang ZL*, Urade Y and Hayaishi O, The role of adenosine in the regulation of sleep. Curr Top Med Chem, 2011, 11(8):1047-57.
  31. Qu WM, Xu XH, Yan MM, Wang YQ, Urade Y, Huang ZL*. Essential role of dopamine D2 receptor in the maintenance of wakefulness, but not in homeostatic regulation of sleep, in mice. J Neurosci, 2010, 30(12):4382-4389.
  32. Oishi Y, Huang ZL*, Fredholmd BB, Uradea Y and Hayaishi O. Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non- rapid eye movement sleep. Proc Natl Acad Sci USA, 2008, 105(50):19992-19997.
  33. Qu WM, Huang ZL*, Xu XH, Matsumoto N and Urade Y. Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil. J Neurosci 2008, 28(34): 8462-8469.
  34. Huang ZL*, Urade Y and Hayaishi O. Prostaglandins and adenosine in the regulation of sleep and wakefulness. Curr Opin Pharmacol 2007; 7(1): 33-38. 
  35. Kanekiyo T, Aritake S, Yamaguchi K,Huang ZL, Qu WM,Ozono K, Taniike M, Goto Y, Urade Y. Lipocalin-type PGD synthase is a major amyloid β-chaperone in human cerebrospinal fluid. Proc Natl Acad Sci USA, 2007, 104(15): 6412-6417.
  36. Nishida N, Huang ZL*, Mikuni N, Miura Y, Urade Y and Hashimoto N. Deep brain stimulation of the posterior hypothalamus activates the histaminergic system to exert antiepileptic effect in rat pentylentetrazol model. Exp Neurol 2007; 205(1): 132-144.
  37. Ferré S, Diamond I, Godlberg SR, Yao L, Hourani SMO, Huang ZL, Urade Y and Kitchen I. Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry. Implications for drug addiction, sleep and pain. Prog Neurobiol 2007; 83:332-347.
  38. Chen CR, Qu WM, Qiu MH, Xu XH, Yao MH, Urade Y and Huang ZL*. Modafinil exerts a dose-dependent antiepileptic effect mediated by adrenergic α1 and histaminergic H1 receptors in mice. Neuropharmacology 2007; 53(4):534-541.
  39. Qu WM, Huang ZL, Xu XH, Aritake K, Eguchi O, Nambu F, Narumiya S, Urade Y and Hayaishi O. Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. Proc Natl Acad Sci USA, 2006; 103(47):17949-17954.
  40. Huang ZL, Mochizuki T, Qu WM, Hong ZY, Watanabe T, Urade Y and Hayaishi O. Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice. Proc Natl Acad Sci USA 2006, 103(12): 4687-4692.
  41. Huang ZL, Qu WM, Eguchi, N, Chen JF, Schwarzschild MA, Fredholm BB, Urade Y and Hayaishi O. Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nat Neurosci 2005; 8(7): 858-859.
  42. Hong ZY, Huang ZL*, Qu WM, Eguchi N, Urade Y and Hayaishi O. An adenosine A2A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats. J Neurochem 2005; 92:1542-1549.
  43. Huang ZL, Sato Y, Mochizuki T, Okada T, Qu WM, Yamatodani A, Urade Y and Hayaishi O. Prostaglandin E2 activates the histaminergic system via EP4 receptor to induce wakefulness in rats. J Neurosci 2003; 23(14):5975-5983.
  44. Huang ZL, Qu WM, Li WD, Mochizuki M, Eguchi N, Watanabe T, Urade Y and Hayaishi O. Arousal effect of orexin A depends on activation of the histaminergic system. Proc Natl Acad Sci USA 2001; 98(17): 9965-9970.
  45. Mizoguchi A, Eguchi N, Kimura K, Kiyohara Y, Qu WM, Huang ZL, Mochizuki T, Lazarus M, Kobayashi T, Kaneko T, Narumiya S, Urade Y and Hayaishi O. Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. Proc Natl Acad Sci USA 2001; 98(20): 11674-11679.

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