系简介
       复旦大学基础医学院前身为上海第一医学院基础医学部,建于1955年4月。1992年12月基础医学部更名为基础医学院。2000年4月,上海医科大学和复旦大...

黄志力

     

  

复旦大学特聘教授、博士生导师,国家杰出青年科学基金获得者、上海市领军人才、上海市优秀学科带头人。1992、1997年,二次获笹川医学奖学金赴日本留学;1999年,获博士学位。1999年起,任日本学术振兴会JSPS博士后、大阪生命科学研究所研究员,研究副部长;2005年12月加盟复旦大学。现任上海医学院药理学系主任、基础医学院副院长。

学会兼职:1) 中国睡眠研究会睡眠生理和药理专委会主任委员、中国药理学会麻醉药理学专业委员会副主任委员、上海市药理学会副理事长、上海市药学会药理专业委员会副主任委员、中国中西医结合学会生物节律专业委员会副主任委员、中国药理学会理事、中国神经科学会理事、日本睡眠学会评议员。

学术期刊任职:(1)副主编:《Frontier in Neuroscience》(SCI)、《Sleep and Breathing》(SCI)、《Sleep Biol Rhythms》(SCI)、《中国临床药理学与治疗学》、《世界睡眠医学杂志》;(2)编委或常务编委:Acta Pharmacol Sin》(SCI)、《药学学报》、《中国药理学通报》、《中药药理与临床》、《四川精神卫生》、《神经药理学》和《生物物理学报》等。

研究方向: 分子行为药理学、睡眠与失眠机制,镇静催眠药物开发。

招生专业: 神经精神药理学、神经生物学

基金项目:国家新药创制“重大科技专项”、国家杰出青年科学基金、国家自然科学基金重点项目,重点国际合作,创新群体、国家基础研究973、上海市领军人才和上海市优秀学科带头人计划、重点攻关及重点项目等课题。国内、外制药企业合作研究项目。

论文发表:以中、英、日三种文字发表研究论文与综述150多篇,其中SCI杂志收录100篇,包括Nature Neuroscience, Light: Science & Applications, Nature Communications, PLos Biology,PNAS,eLife, Neuropsychopharmacology,Journal of Neuroscience等国际著名学术期刊,累计影响因子460,2014-2017年连续上榜爱思唯尔(Elsevier)发布的中国学术论文高被引学者榜单。应邀为Trends Neurosci, Prog Neurobiol, Curr Opin Neurosci, Curr Opin Pharmacol等杂志撰写综述,为PNAS, J Neurosci, Neuropharmacology, Br J Pharmacol等20个SCI杂志审稿。多次应邀赴美国、德国、法国、日本、澳大利亚、乌拉圭、新加坡、印度、泰国、韩国等国家作学术报告。

获奖:获教育部高等学校科学研究优秀成果奖(自然科学)、日本睡眠学会“优秀研究奖”和中国医师协会“中国睡眠研究杰出贡献奖”等。

 

联系方式:电子邮件:huangzl@fudan.edu.cn


代表性文章

Wu YE, Enoki R*, Oda Y, Huang ZL*, Honma K, Honma S. Ultradian Calcium Rhythms in the Paraventricular Nucleus and Subparaventricular Zone in the Hypothalamus. Proc Natl Acad Sci U S A. 2018 Sep 18. pii: 201804300. doi: 10.1073/pnas.1804300115.

Wang TX#, Xiong B#, Xu W, Wei HW, Qu WM, Hong ZY, Huang ZL*. Activation of Parabrachial Nucleus Glutamatergic Neurons Accelerates Reanimation from Sevoflurane Anesthesia in Mice. Anesthesiology, 2018, in press.

Luo YJ#, Li YD#, Wang L#, Yang SR, Yuan XS, Wang J, Cherasse Y, Lazarus M, Chen JF, Qu WM, and Huang ZL*. Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D1 receptors. Nature Communications, 2018 Apr 20;9(1):1576. doi: 10.1038/s41467-018-03889-3.

Yang SR*, Hu ZZ, Luo YJ, Zhao YN, Sun HX, Yin D, Wang CY, Yan YD, Wang DY, Yuan XS, Ye CB, Guo W, Qu WM, Cherasse Y, Lazarus M, Ding YQ, Huang ZL*. The rostromedial tegmental nucleus is essential for non-rapid eye movement sleep. PLoS Biology, 2018 Apr 13;16(4):e2002909. doi: 10.1371/journal.pbio.2002909.

Oishi Y#, Xu Q#, Wang L#, Zhang BJ, Takahashi K, Takata Y, Luo YJ, Cherasse Y, Schifmann S, de Kerchove d'Exaerde A, Urade Y, Qu WM, Huang ZL*, and  Lazarus M*. Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice. Nature Communications, 2017 Sep 29;8(1):734. doi: 10.1038/s41467-017-00781-4.

Yuan XS#, Wang L#, Dong H#, Qu WM, Yang SY, Cherasse Y, Lazarus M, Schifmann S, de Kerchove d'Exaerde A, Li RX* and Huang ZL*. Striatal adenosine A2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus. eLife, 2017, 2017 Oct 12;6. pii: e29055. doi: 10.7554/eLife.29055.

Zhang Z#, Wang HJ#, Wang DR, Qu WM* and Huang ZL*. Red light alters sleep-wake behavior at intensities above 10 lx in mice. Light: Science & Applications. 2017, DIO:10.1038/lsa.2016.231. (IF: 14.1).

Chen L, Yin D, Wang TX, Guo W, Dong H, Xu Q, Luo YJ, Cherasse Y, Lazarus M, Qiu ZL, Lu J, Qu WM*, and Huang ZL*. Basal forebrain cholinergic neurons primarily contribute to inhibition of electroencephalogram delta activity, rather than inducing behavioral wakefulness in mice. Neuropsychopharmacology, 2016 Jul;41(8):2133-46.

Chen CR, Sun Y, Luo YJ, Zhao X, Chen JF, Yanagawa Y, Qu WM, and Huang ZL*. Paeoniflorin Promotes Non-rapid Eye Movement Sleep via Adenosine A1 Receptors. J Pharmacol Exp Ther, 2016, 356:64–73.

Li Y, He Y, Chen M, Pu Z, Chen L, Li P, Li B, Li H, Huang ZL, Li Z, and Chen JF. Optogenetic Activation of Adenosine A2A Receptor Signaling in the Dorsomedial Striatopallidal Neurons Suppresses Goal-Directed Behavior. Neuropsychopharmacology. 2016 Mar;41(4):1003-13.

Zhang GH§, Liu ZL§, Zhang BJ; Geng WY, Song NN, Zhou W, Cao YX, Li SQ; Huang ZL*, Shen LL*, Orexin A activates hypoglossal motoneurons and enhanced genioglossus muscle activity in rats. Br J Pharmacol. 2014, 171:4233–4246.

Cho S, Yoon M, Pae AN, Jin YH, Cho NC, Takata Y, Urade Y, Kim S, Kim JS, Yang H, Kim J; Kim J, Han, JK, Shimizu M, Huang ZL*. Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor. Psychopharmacology (Berl). 2014; 231:2825-2837.

Liu YY§, Yin D§, Chen L, Qu WM, Laudon M, Cheng NN, Urade Y, Huang ZL*, Antinociceptive and hypnotic effects of piromelatine in a mouse model of neuropathic pain. Psychopharmacology, 2014; Apr 4. [Epub ahead of print].

Han Y, Shi YF, Xi W, Zhou R, Tan ZB, Wang H, Li XM, Chen Z, Feng G, Luo M, Huang ZL, Duan S, Yu YQ, Selective Activation of Cholinergic Basal Forebrain Neurons Induces Immediate Sleep wake Transitions. Curr Biol, 2014 Mar 17;24(6):693-8.

Xu XH, Qiu MH, Dong H, Qu WM*, Urade Y, Huang ZL*, GABA transporter-1 inhibitor NO-711 alters the EEG power spectra and increases non-rapid eye movement sleep during the active phase in mice. Eur Neuropsychopharmacol, 2014; 24, 585–594.

Wang Q, Yue XF, Qu WM*, Tan R, Zheng P, Urade Y and Huang ZL*, Morphine inhibits sleep-promoting neurons in the ventrolateral preoptic area via mu receptors and induces wakefulness in rats, Neuropsychopharmacology, 2013; 38(5):791-801.

Lazarus M, Chen JF, Urade Y, and Huang ZL*, Role of the basal ganglia in the control of sleep and wakefulness. Curr Opin Neurobiol, 2013;23(5):780-785.

Lazarus M, Huang ZL, Lu J, Urade Y, Chen JF. How do the basal ganglia regulate sleep-wake behavior? Trends Neurosci, 2012, 35: 723-732.

Chen CR, Zhou XZ, Luo YJ, Huang ZL*, Urade Y, Qu WM*, Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABAA receptor in mice. Neuropharmacology, 2012, 63: 1191-1199.

Qu WM, Yue XF, Sun Y, Fan K, Chen CR, Hou YP, Urade Y and Huang ZL*, Honokiol promotes non-rapid eye movement sleep via the benzodiazepine site of the GABAreceptor in mice. Br J Pharmacol, 2012, Oct;167(3): 587-598.

Zhao X, Xu Y, Zhao Q, Chen CR, Liu AM, and Huang ZL*, Curcumin exerts antinociceptive effects in a mouse model of neuropathic pain: descending monoamine system and opioid receptors are differentially involved, Neuropharmacology, 2012, 62: 843-854.

Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass C, Winsky-Sommerer R, Semba K, Fredholm B, Boison D, Hayaishi O, Urade Y, Chen JF. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens, J Neurosci, 2011, 31(27):10067–10075.

Chen CR, Tan R, Qu WM, Wu Z, Wang Y, Urade Y, Huang ZL*. Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts anti-epileptic effects via GABA-benzodiazepine receptor complex in mice, Br J Pharmacol, 2011, 164(5):1534-46.

Qu WM, Xu XH, Yan MM, Wang YQ, Urade Y, Huang ZL*. Essential role of dopamine D2 receptor in the maintenance of wakefulness, but not in homeostatic regulation of sleep, in mice. J Neurosci, 2010, 30(12):4382-4389.

Oishi Y, Huang ZL*, Fredholmd BB, Uradea Y and Hayaishi O. Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep. Proc Natl Acad Sci USA, 2008, 105(50):19992-19997.

Qu WM, Huang ZL*, Xu XH, Matsumoto N and Urade Y. Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil. J Neurosci 2008, 28(34): 8462-8469.

Huang ZL, Urade Y and Hayaishi O. Prostaglandins and adenosine in the regulation of sleep and wakefulness. Curr Opin Pharmacol 2007; 7(1): 33-38.  

Kanekiyo T, Aritake S, Yamaguchi K,Huang ZL, Qu WM,Ozono K, Taniike M, Goto Y, Urade Y. Lipocalin-type PGD synthase is a major amyloid β-chaperone in human cerebrospinal fluid. Proc Natl Acad Sci USA, 2007, 104(15): 6412-6417.

Ferré S, Diamond I, Godlberg SR, Yao L, Hourani SMO, Huang ZL, Urade Y and Kitchen I. Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry. Implications for drug addiction, sleep and pain. Prog Neurobiol 2007; 83:332-347.

Qu WM, Huang ZL, Xu XH, Aritake K, Eguchi O, Nambu F, Narumiya S, Urade Y and Hayaishi O. Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. Proc Natl Acad Sci USA, 2006; 103(47):17949-17954.

Huang ZL, Mochizuki T, Qu WM, Hong ZY, Watanabe T, Urade Y and Hayaishi O. Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice. Proc Natl Acad Sci USA 2006, 103(12): 4687-4692.

Huang ZL, Qu WM, Eguchi, N, Chen JF, Schwarzschild MA, Fredholm BB, Urade Y and Hayaishi O. Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nat Neurosci 2005; 8(7): 858-859.

Huang ZL, Sato Y, Mochizuki T, Okada T, Qu WM, Yamatodani A, Urade Y and Hayaishi O. Prostaglandin E2 activates the histaminergic system via EP4 receptor to induce wakefulness in rats. J Neurosci 2003; 23(14):5975-5983.

Huang ZL, Qu WM, Li WD, Mochizuki M, Eguchi N, Watanabe T, Urade Y and Hayaishi O. Arousal effect of orexin A depends on activation of the histaminergic system. Proc Natl Acad Sci USA 2001; 98(17): 9965-9970.

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