系简介
       复旦大学基础医学院前身为上海第一医学院基础医学部,建于1955年4月。1992年12月基础医学部更名为基础医学院。2000年4月,上海医科大学和复旦大...

曲卫敏


       

曲卫敏,复旦大学基础医学院药理学系教授、博导。1986和1989年分别获医学学士、硕士学位。2000年在日本获医学博士学位。2000-2008年,日本大阪生命科学研究所博士后;日本文部省学术振兴会(JSPS)特别研究员。2008年,作为引进人才进入复旦大学。

研究方向:神经精神药理学、睡眠与失眠的分子机制、开发镇静催眠药物。主持国家自然基金面上项目、国际合作项目、国家基础研究重大项目973、上海市科委科技攻关重点项目和浦江人才计划等项目。共发表SCI论文60余篇,包括Nat Neurosci, Light Sci & Appl, PNAS, J Neurosci, Neuropsychopharmacology, Br J Pharmacol等。

e-mail: quweimin@fudan.edu.cn

 

 

主要学术论文:(*通讯作者)

  1. 1.Zhang Z#, Wang HJ#, Wang DR, Qu WM*, Huang ZL*. Red light at intensities above 10 lx alters sleep-wake behavior in mice. Light Science & Applications. 2017, 6, e16231. (IF: 14.098)
  2. 2. Wang YQ#, Li R#, Wang DR#, Cherasse Y, Zhang Z, Zhang MQ, Lavielle O, McEown K, Schiffmann SN, de Kerchove d'Exaerde A, Qu WM*, Lazarus M*, Huang ZL*. Adenosine A2A receptors in the olfactory bulb suppress rapid eye movement sleep in rodents. Brain Struct Funct. 2017, 222(3):1351-1366. (IF: 4.698)
  3. 3. Fang T, Dong H, Xu XH, Yuan XS, Chen ZK, Chen JF, Qu WM*, Huang ZL*. Adenosine A2A receptor mediates hypnotic effects of ethanol in mice. Sci Rep. 2017, 7(1):12678. (IF: 4.259)
  4. 4. Zhang BJ, Shao SR, Aritake K, Takeuchi A, Urade Y, Huang ZL, Lazarus M*, Qu WM*. Interleukin-1β induces sleep independent of prostaglandin D2 in rats and mice. Neuroscience 2017, 340:258-267. (IF: 3.277)

5. Zhang BJ, Huang ZL, Chen J-F, Urade Y*, Qu WM*. Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2. Acta Pharmacologica Sinica. 2017, 38(4): 469–476. (IF: 3.223)

6. Yuan XS, Wang L, Dong H, Qu WM, Yang SR, Cherasse Y, Lazarus M, Schiffmann SN, d'Exaerde AK, Li RX*, Huang ZL*. Striatal adenosine A2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus. Elife. 2017, 6. pii: e29055. (IF: 7.725)

7. Chen L, Yin D, Wang TX, Guo W, Dong H, Xu Q, Luo YJ, Cherasse Y, Lazarus M, Qiu ZL, Lu J, Qu WM*, Huang ZL*. Basal Forebrain Cholinergic Neurons Primarily Contribute to Inhibition of Electroencephalogram Delta Activity, Rather than Inducing Behavioral Wakefulness in Mice. Neuropsychopharmacology. 2016, 41(8):2133-2146. (IF: 7.048)

  1. 8. Chen CR, Sun Y, Luo YJ, Zhao X, Chen JF, Yanagawa Y, Qu WM*, Huang ZL*. Paeoniflorin Promotes Non-rapid Eye Movement Sleep via Adenosine A1 Receptors. J Pharmacol Exp Ther. 2016, 356(1):64-73. (IF: 3.972)
  2. 9. Wang YQ*, Li R, Wu X, Zhu F, Takata Y, Zhang Z, Zhang MQ, Li SQ*, Qu WM*. Fasting activated histaminergic neurons and enhanced arousal effect of caffeine in mice. Pharmacol Biochem Behav 2015, 133:164-173. (IF: 2.82)
  3. 10. Xu XH, Qiu MH, Dong H, Qu WM*, Urade Y, Huang ZL*, GABA transporter-1 inhibitor NO-711 alters the EEG power spectra and increases non-rapid eye movement sleep during the active phase in mice. Eur Neuropsychopharmacol, 2014, 24(4):585-594. (IF: 5.395)
  4. 11. Liu YY§, Yin D§, Chen L, Qu WM*, Laudon M, Cheng NN, Urade Y, Huang ZL*. Piromelatine exerts antinociceptive effect via melatonin, opioid, and 5HT1A receptors and hypnotic effect via melatonin receptors in a mouse model of neuropathic pain. Psychopharmacology, 2014, 231(20): 3973-3985. (IF: 4.061)
  5. 12. Wang Q, Yue XF, Qu WM*, Tan R, Zheng P, Urade Y and Huang ZL*, Morphine inhibits sleep-promoting neurons in the ventrolateral preoptic area via mu receptors and induces wakefulness in rats, Neuropsychopharmacology, 2013; 38(5):791-801. (IF: 8.678)
  6. 13. Qu WM*, Yue XF, Sun Y, Fan K, Chen CR, Hou YP, Urade Y, Huang ZL*. Honokiol promotes non-rapid eye movement sleep via the benzodiazepine site of the GABA(A) receptor in mice. Br J Pharmacol. 2012, 2012, 167(3): 587-596. (IF: 4.92)
  7. 14. Wang YQ, Tu ZC, Xu XY, Qu WM*, Urade Y, Huang ZL*. Acute administration of fluoxetine normalizes rapid eye movement sleep abnormality, but not depressive behaviors in olfactory bulbectomized rats. J Neurochem, 2012, 120(2):314-324. (IF: 4.34)
  8. 15. Chen CR, Zhou XZ, Luo YJ, Huang ZL*, Urade Y, Qu WM*. Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABAA receptor in mice. Neuropharmacology, 2012, 63(6): 1191-1199. (IF: 4.814)
  9. 16. Qu WM, Xu XH, Yan MM, Wang YQ, Urade Y, Huang ZL*. Essential role of dopamine D2 receptor in the maintenance of wakefulness, but not in homeostatic regulation of sleep, in mice. J Neurosci 2010, 30(12):4382– 4389. (IF: 7.49)
  10. 17. Qu WM, Huang ZL, Xu XH, Matsumoto N, Urade Y. Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil. J Neurosci 2008, 28(34):8462-9. (IF: 7.49)
  11. 18. Qu WM, Huang ZL, Xu XH, Aritake K, Eguchi N, Nambu F, et al. Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. Proc Natl Acad Sci USA 2006, 103(47):17949-54. (IF: 9.598)

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