系简介
       复旦大学基础医学院前身为上海第一医学院基础医学部,建于1955年4月。1992年12月基础医学部更名为基础医学院。2000年4月,上海医科大学和复旦大...

马兰


       1958年9月出生,国家杰出青年基金获得者,973首席科学家,博士生导师,复旦大学脑科学研究院院长,复旦大学药理研究中心主任,Journal of Biological Chemistry和Neuropharmacology等国际刊物编委,中国生理学会副理事长。研究方向为药物成瘾的分子机制,目前作为负责人承担科技部973项目、自然科学基金委创新研究群体等项目。在Cell,PNAS,Neuropsychopharmacology等刊物发表SCI论文70余篇,被引用近2000次。获国家自然科学二等奖一项、省部级科技一等奖四项,并获何梁何利科技进步奖等荣誉;主讲的课程获国家教学成果二等奖和上海市教学成果一等奖各一项;指导的研究生论文中有多篇被评为全国优秀博士学位论文或上海市优秀研究生论文。


代表性论文:
1. Li Wang, Minjie Shen, Yongchun Yu, Yezheng Tao, Ping Zheng, Feifei Wang*, Lan Ma*. (2014) Optogenetic activation of GABAergic neurons in the nucleus accumbens decreases the activity of the ventral pallidum and the expression of cocaine-context-associated memory. Int J Neuropsychopharmacol 17 (5): 753-763.
2. Haohong Li, Yezheng Tao, Li Ma, Xing Liu*, Lan Ma. (2013) β-Arrestin-2 inhibits preference for alcohol in mice and suppresses Akt signaling in the dorsal striatum. Neurosci Bull 29 (5): 531-540.
Hui Long, Xinru Zhu, Ping Yang, Qinqin Gao, Yuejun Chen*, Lan Ma*. (2013) Myo9b and RICS modulate dendritic morphology of cortical neurons. Cereb Cortex 23 (1): 71-79.
3. Ziyan Wu, Yuejun Chen*, Tong Yang, Qinqin Gao, Man Yuan, Lan Ma. (2012) Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. PLoS One 7 (8): e43997.
4. Li Wang, Minjie Shen, Feifei Wang*, Lan Ma. (2012) GRK5 ablation contributes to insulin resistance. Biochem Biophys Res Commun 429 (1-2): 99-104.
5. Ruhui Lu, Xing Liu, Hui Long*, Lan Ma*. (2012) Effects of prenatal cocaine and heroin exposure on neuronal dendrite morphogenesis and spatial recognition memory in mice. Neurosci Lett 522 (2): 128-133.
6. Feifei Wang, Li Wang, Minjie Shen, Lan Ma*. (2012) GRK5 deficiency decreases diet-induced obesity and adipogenesis. Biochem Biophys Res Commun 421 (2): 312-317.
7. Yuejun Chen, Feifei Wang, Hui Long, Ying Chen, Ziyan Wu, Lan Ma*. (2011) GRK5 promotes F-actin bundling and targets bundles to membrane structures to control neuronal morphogenesis. J Cell Biol 194 (6): 905-920. Published 09/19/2011
8. Sheng Jian, Lv Zhigang, Wang Lei, Zhou Yuqing*, Hui Bin*. (2011) Histone H3 phosphoacetylation is critical for heroin-induced place preference. Neuroreport 22 (12): 575-580.
9. Xiaoqing Chen, Huiling Zhu, Man Yuan, Jie Fu, Yuqing Zhou, Lan Ma*. (2010) G-protein-coupled Receptor Kinase 5 Phosphorylates p53 and Inhibits DNA Damage-induced Apoptosis. J. Biol. Chem. 285 (17): 12823-12830.
10. Lei Wang, Zhigang Lv, Zhaoyang Hu, Jian Sheng, Bin Hui, Jie Sun, Lan Ma*. (2010) Chronic cocaine-induced H3 acetylation and transcriptional activation of CaMKII in the nucleus accumbens is critical for motivation for drug reinforcement. Neuropsychopharmacology 35 (4): 913-928.
11. Yuting Li, Haohong Li, Xing Liu, Guobin Bao, Yezheng Tao, Ziyang Wu, Peng Xia, Chunfu Wu, Baoming Li and Lan Ma*. (2009) Regulation of amygdalar PKA by beta-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning. Proc Natl Acad Sci USA December 22, 2009; 106 (51): 21918-21923.
12. Xi Jiang, Peng Yang and Lan Ma*. (2009) Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development. Proc Natl Acad Sci USA June 23, 2009; 106 (25): 10183-10188.
13. Yuejun Chen, Hui Long, Ziyan Wu, Xi Jiang, Lan Ma*. (2008) EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation. Mol Biol Cell. 19: 2973-2983. 
14. Wang FF, Chen XQ, Zhang XQ, Ma L*. (2008) Phosphorylation state of mu-opioid receptor determines the alternative recycling of receptor via Rab4 or Rab11 pathway. Mol. Endocrinol. 22(8): 1881-1892. 
15. Xiaoqing Zhang, Feifei Wang, Xiaoqing Chen, Yuejun Chen, Lan Ma*. (2008) Post-endocytic fates of delta-opioid receptor are regulated by GRK2-mediated receptor phosphorylation and distinct beta-arrestin isoforms. J Neurochem. 106: 781-792. 
16. Chen Y, Jiang Y, Yue W, Zhou Y, Lu L, Ma L*. (2008) Chronic, but not acute morphine treatment, up-regulates alpha-Ca2+/calmodulin dependent protein kinase II gene expression in rat brain. Neurochem Res. 33 (10): 2092-2098. 
17. Jie Sun, LeiWang, Baohong Jiang, Bin Hui, Zhigang Lv, Lan Ma*. (2008) The effects of sodium butyrate, an inhibitor of histone deacetylase, on the cocaine- and sucrose-maintained self-administration in rats. Neuroscience Letters. 441: 72-76. 
18. Xi Jiang, Jing Li and Lan Ma*. (2007) Metabolic enzymes link morphine withdrawal with metabolic disorder. Cell Research. 17: 741-43. 
19. Wang W, Zhou Y, Sun J, Pan L, Kang L, Dai Z, Yu R, Jin G, Ma L*. (2007) The effect of l-stepholidine, a novel extract of Chinese herb, on the acquisition, expression, maintenance, and re-acquisition of morphine conditioned place preference in rats. Neuropharmacology. 52: 355-361. 

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