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长江特聘
汤其群
发表时间:2013-03-13 阅读次数:6906次

    汤其群,(1966~) 江苏盐城人。教授,博士生导师。1990年毕业于上海医科大学法医学系, 1995年获得上海医科大学生物化学与分子生物学博士学位,同年赴美国Johns Hopkins大学医学院生物化学系作博士后。2002年受聘为Johns Hopkins大学医学院儿科内分泌系助理教授兼生化系助理教授。2005年6月辞去美国的职位,全职受聘于复旦大学。曾担任复旦大学上海医学院副院长;现任复旦大学基础医学院院长,生物医学研究院副院长,生物化学与分子生物学系主任,分子医学教育部重点实验室主任;上海生物化学与分子生物学会副理事长,中国医学生物化学与分子生物学协会副理事长。

    汤其群教授为第二批教育部“长江学者奖励计划”特聘教授(1999),为国家自然科学基金委“杰出青年基金”获得者(2006),为国家重大科学研究计划“干细胞定向分化的基础与临床应用研究”的首席科学家,2005年入选上海市首批“医学领军人才”,2007年入选上海市领军人才,并被评为优秀学科带头人,2009年入选国家“百千万人才计划”国家级人选, 2010年被Johns Hopkins大学生物化学系聘为兼职教授(Adjunct Professor),被美国中华医学基金会评为CMB杰出教授。

    主要从事研究脂肪细胞发育分化的机理和肥胖的成因,以及有效地控制肥胖的方法。发表论文50余篇,多数在PNAS、GENES & DEVELOPMENT、MCB、MCP、JBC等SCI杂志上发表。曾获上海市科技进步一等奖,卫生部科技进步一等奖、国家科技进步二等奖,“霍英东优秀青年教师”一等奖(生物类)和谈家桢生命科学创新奖。

 

1.Yan Jiang, Liang Guo, Li-Qi Xie, You-You Zhang, Xiao-Hui Liu, Yang Zhang, Hao Zhu, Peng- Yuan Yang, Hao-Jie Lu, Qi-Qun Tang*. (2014) Proteome profiling of mitotic clonal expansion during 3T3-L1 adipocyte differentiation using iTRAQ-2DLC-MS/MS. J. Proteome Res. 2014 Mar 7;13(3):1307-14.

2.Yang Liu, Ya-Dong Zhang, Liang Guo, Hai-Yan Huang, Hao Zhu, Jia-Xin Huang, Yuan Liu, Shui-Rong Zhou, Yong-Jun Dang, Qi-Qun Tang*. (2013) Protein Inhibitor of Activated STAT 1 (PIAS1) Is Identified as the SUMO E3 Ligase of CCAAT/Enhancer-Binding Protein β (C/EBPβ) during Adipogenesis. Mol Cell Biol. 33(22):4606-17 (Selected as a Spotlight by the Editors)

3.Liang Guo, Jia-Xin Huang, Yuan Liu, Xi Li, Shui-Rong Zhou, Shu-Wen Qian, Yang Liu,  Hao Zhu, Hai-Yan Huang, Yong-Jun Dang, Qi-Qun Tang*. (2013)  Transactivation of Atg4b by C/EBPβ Promotes Autophagy to Facilitate Adipogenesis.  Mol Cell Biol. 33(16):3180-3190

4.Yuan Liu, Zhi-Chun Zhang, Shu-Wen Qian, You-you Zhang, Hai-yan Huang, Yan Tang1, Liang Guo1, Xi Li, and Qi-Qun Tang*. (2013) MicroRNA-140 promotes adipocyte lineage commitment of C3H10T1/2 pluripotent stem cell via targeting Osteopetrosis-associated transmembrane protein 1. J. Biol. Chem. 288(12):8222-30

5.Shu-wen Qian, Yan Tang, Xi Li, Yuan Liu, You-you Zhang, Hai-yan Huang, Rui-Dan Xue, Hao-yong Yu, Liang Guo, Hui-di Gao, Yan Liu, Xia Sun, Yi-ming Li, Wei-Ping Jia, Qi-Qun Tang*. (2013) BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc Natl Acad Sci USA. 110(9):E798-807

6.Hai-Yan Huang,  Su-Zhen Chen ,  Wen-Ting Zhang,  Shan-Shan Wang ,  Yang Liu,  Xi Li,  Xia Sun,  Yi-Ming Li,  Bo Wen,
  Qun-Ying Lei, Qi-Qun Tang*. (2013) Induction of EMT-like response by BMP4 via up-regulation of lysyl oxidase is required for adipocyte lineage commitment. Stem Cell Research. 10(3): 278-287

7.Liang Guo, Xi Li, Jia-Xin Huang, Hai-Yan Huang, You-You Zhang, Shu-Wen Qian, Hao Zhu, Ya-Dong Zhang, Yang Liu, Yuan Liu, Kan-Kan Wang, Qi-Qun Tang*. (2012) Histone Demethylase Kdm4b Functions as a Co-Factor of C/EBPβ to Promote Mitotic Clonal Expansion During Differentiation of 3T3-L1 Preadipocytes. Cell Death Differ. 19(12): 1917-1927.

8.Qi-Qun Tang*, M. Daniel Lane. (2012) Adipogenesis: From stem cell to adipocyte. Annu Rev Biochem. 81:715-736.

9.You-You Zhang, Xi Li, Shu-Wen Qian, Liang Guo, Hai-Yan Huang, Qun He, Yuan Liu, Chun-Gu Ma, and Qi-Qun Tang*. (2011) Transcriptional activation of histone H4 by C/EBP during the mitotic clonal expansion of 3T3-L1 adipocyte differentiation. Mol Biol Cell, 22: 2165-74.

10.Hai-Yan Huang, Ling-Ling Hu, Tan-Jing Song, Xi Li, Qun He, Xia Sun, Yi-Ming Li, Hao-Jie Lu, Peng-Yuan Yang, and Qi-Qun Tang*. (2011) Involvement of cytoskeleton-associated proteins in the commitment of C3H10T1/2 pluripotent stem cells to adipocyte lineage induced by BMP2/4. Mol Cell Proteomics 10(1): 1-8.

11.Haiyan Huang, Tan-Jing Song, Xi Li, Lingling Hu, Qun He, Mei Liu, M. Daniel Lane, Qi-Qun Tang*. (2009) The BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage, Proc Natl Acad Sci USA. 106: 12670-5.

12.Xi Li, Henrik Molina, Haiyan Huang, You-you Zhang, Mei Liu, Shu-wen Qian, Chad Slawson, Wagner B. Dias, Akhilesh Pandey, Gerald W. Hart, M. Daniel Lane, Qi-Qun Tang*. (2009) O-linked N-acetylglucosamine modification on C/EBP role during adipocyte differentiation,   J. Biol. Chem., 284: 19248-19254.

 

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