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教授
陈红
发表时间:2015-05-06 阅读次数:5567次

陈红,复旦大学基础医学院人体解剖与组织胚胎学系教授、博导。上海医科大学医学学士、医学硕士,香港大学哲学博士、Mrs. Ivy Wu Fellow,美国特拉华大学博士后、哈佛大学医学院MGH生殖中心访问教授。美国生殖研究学会SSR、香港内分泌、代谢与生殖学会HKSEMR常务会员,中国解剖学会会员。国际权威学术期刊PLoS ONE及其PLoS系列杂志和Antioxid. Redox Signal.杂志审稿人。国家科技部和自然科学基金委评审专家。曾先后荣获上海市研究生优秀成果(学位论文)导师奖,复旦大学青年教师教学比赛三等奖,复旦大学基础医学院院长奖银奖,复旦大学郑思兢教授基金奖,英国生殖与生育SRF学会 TREBR 奖,中国鲁超预防基金奖等荣誉称号。


主要从事精子细胞分化发育与男性不育的表观遗传学研究。作为项目负责人,先后主持国家自然科学基金面上项目3项,参与国家973项目子课题1项(主要骨干),研究成果主要发表在Free Radical Biology & Medicine、Antioxid. Redox Signal.等国际权威杂志上,并获得美国专利1项。指导本科生科创项目荣获全国第二届大学生基础医学创新论坛暨实验设计大赛三等奖。


负责研究生《生殖医学与生殖生物学》和本科生全英语课程《Histology & Embryology》的授课和课程建设,其中《Histology & Embryology》荣获上海高校外国留学生英语授课示范性课程和上海高校示范性全英语课程(复旦大学精品课程网站http://jpkc.fudan.edu.cn/s/426/main.htm),上海市级教学成果二等奖和复旦大学教学成果一等奖。主编人民卫生出版社出版的《Practical Manual of Histology》全英语教材和《组织学实习指导》教材两部;参编多媒体《中华医学百科全书—人体组织学与胚胎学分卷》,《现代组织学》和参译《The Human Body》等论著和译著3部。

 

联系方式:
电话:+ 86-21-54237019,转9304
E-mail: hchen30@hotmail.com; hchen@graduate.hku.hk

 

主要研究方向:
1.精子细胞分化发育与男性不育的表观遗传机制Sperm epigenetics in male infertility
2.精子线粒体发育与异常的分子机制Sperm mitochondria disorders and mechanisms
3.精子DNA损伤与修复的分子机制 Sperm DNA damage and repair mechanisms

 

代表性论文:
1.Wang MJ, Ou JX, Chen GW, Wu JP, Shi HJ, O WS, Martin-DeLeon PA. Chen H*. (2012) Does prohibitin expression regulate sperm mitochondrial membrane potential, sperm motility and male fertility? Antioxid Redox Signal. 17(3):513-519. *通讯作者


2.Chen H*, Cheung MPL, Chow PH, Cheung ALM and O WS*. (2012) The Effects of Sperm DNA Damage on the Levels of RAD51 and p53 Proteins in Zygotes and 2-cell Embryos Sired by Golden Hamsters without the Major Accessory Sex Glands. Free Radical Biology & Medicine. 53: 885-892. *共同通讯作者
 

3.Shi TY, Chen G, Huang X, Yuan Y, Wu X, Wu B, Li Z, Shun F, Chen H* & Shi HJ*. (2012) Effects of reactive oxygen species from activated leucocytes on human sperm motility, viability and morphology. Andrologia. 44: 696-703. *共同通讯作者
 

4.Chen H*, Zhao HX*, Huang XF, Chen GW, Yang Z, Sun W, Tao MH, Yuan Y, Wu J, Sun F, Dai Q, Shi HJ. (2012) Does high load of oxidants in human semen contribute to male factor infertility? Antioxid Redox Signal. 16(8):754-759. *共同第一作者
 

5.Chen H, Griffiths G.S., Galileo D.S., Martin-DeLeon P.A. (2006) Epididymal SPAM1 is a marker for Sperm Maturation in the Mouse. Biol Reprod. 74 (5): 923-930.
 

6.O WS, Chen H, Chow PH. (2006) Male genital tract antioxidant enzymes-Their ability to preserve sperm DNA integrity. Molecular Cell Endocrinology. 250: 80-83.
 

7.Martin-DeLeon PA, Zhang H, Morales CR, Zhao Y, Rulon M, Barnoski BL, Chen H and Galileo DS. (2005) Spam1-associated transmission ratio distortion in mice: Elucidating the mechanism. Reproductive Biology and Endocrinology, 3:32.
 

8.Chen H, Chow PH, Cheng SK, Cheung ALM, Cheng LYL and O WS. (2003) Male genital tract antioxidant enzymes: their source, function in the female and ability to preserve sperm DNA integrity in the golden hamster. Journal of Andrology, 24(5): 704-711.
 

9.Chen H, Cheung MPL, Chow PH, Cheung ALM, Liu W and O WS. (2002) Protection of sperm DNA against oxidative stress in vivo by accessory sex gland secretions in male hamsters. Reproduction, 124: 491-499.
 

10.Chen H and Tong SM. (1998) Effects of Mifepristone (RU486) on Hypophysis, Ovary, Uterus and Placenta in Pregnant Rats. Biomedical and Environmental Sciences, 11(2):133-139.

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