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教授
雷群英
发表时间:2013-03-13 阅读次数:14322次

姓名:雷群英 博士,博导
职称:教授
E-MAIL:  qlei@fudan.edu.cn
实验室站:  http://www.cancermetabolism.fudan.edu.cn/

研究方向
1.肿瘤细胞对营养物质的感受、利用及其调控机制;
2.肿瘤代谢重塑过程中关键代谢酶的调控机制;
3.肿瘤代谢与肿瘤微环境的相互作用机理

重要学术贡献(300字以内)
      雷群英教授研究方向为肿瘤代谢,蛋白质翻译后修饰及其生理病理效应。她的研究揭示了多个代谢酶乙酰化和甲基化在肿瘤代谢中的作用及其调控机制,提出了“代谢酶的乙酰化和甲基化调控通过影响肿瘤细胞代谢,从而干扰肿瘤细胞生长”的观点。近年来的研究聚焦代谢物感受在肿瘤代谢中的作用和分子机制, 发现代谢物可能充当信号分子,从而在在肿瘤发生发展中起着关机作用。这些系统原创性工作为肿瘤代谢的修正治疗提供了理论支持和潜在靶点。更为重要的是作为肿瘤代谢领域的专家,她积极推动了国内肿瘤代谢学科的发展,使我国的肿瘤代谢研究领域在国际上占得一席之地。











荣誉与获奖
2018 全国妇联                        全国三八红旗手
2016上海市妇联                     上海市三八红旗手标兵
2016中央人才工作协调小组    国家高层次人才特殊支持计划(万人计划)
2016 上海市教委                    上海市育才奖
2015 教育部                           长江特聘教授
2015上海市科协                     上海市自然科学牡丹奖
2015 中国女医师协会             五洲女子科技奖基础医学科研创新奖
2014 科技部                           中青年科技创新领军人才
2014 科技部                          973首席科学家                    
2014 教育部                          自然科学二等奖
2013 联合教科文组织            中国青年女科学家奖
2013 上海市科委                   上海市优秀学术带头人
2012 国家自然科学基金委     国家杰出青年科学基金
2012 教育部                          自然科学一等奖    
2012 上海市妇联                  上海市三八红旗手
2011 明治乳液                      明治生命科学奖(杰出奖)
2011 上海市教委                  曙光学者
2011 上海市卫计委              卫生系统优秀学术带头人
2009 教育部                         新世纪优秀人才
2007上海市科委                   浦江人才

国内外学术团体任职
2018 - 今  中国细胞生物学学会细胞代谢分会,会长
2015 - 今  中国医学生物化学与分子生物学分会,副理事长
2015 - 今  上海生物化学与分子生物学学会,副理事长兼秘书长
2015 - 今  中国转化医学联盟,理事
2015 - 今  中国细胞生物学学会,理事
2014 - 今  中国生物化学与分子生物学会,理事

受邀审稿学术刊物
2018- 今    Cell Stress,编委
2016 - 今   Signal Transduction and Therapy Target,编委
2015 - 今   Acta Biochim Biophys Sin (Shanghai),编委
2010 - 今   中国生物化学与分子生物学报,编委

校内学术机构任职(复旦大学)
2017、11 - 今     复旦大学基础医学院副院长
2015–2016  生物化学与分子生物学系主任

受邀学术报告 (近5年国内大会报告、国际重要会议专题报告以上)
1)2013-04  Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer,中国细胞生物学学会第十三次学术大会,武汉
2)2013-07  Acetylation Control of Cancer Metabolism,2013年全球华人生物科学家大会,西安
3)2013-09  PKM2 K305 acetyaltion promotes cancer cell metabolism,中国细胞生物学会(2013) ,北京
4)2014-04  Acetylation Control of Cancer Metabolism, 第10届海峡两岸细胞生物学学术研讨会, 台湾
5)2014-05  Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth ,Ubiquitin国际会议(2014),上海
6)2014-08  Acetylation Control of Metabolic Enzymes in Cancer,中国生物化学与分子生物学会第十三次学术大会 ,厦门
7)2014-09  Acetylation Control of Cancer Metabolism ,AACR会议,上海
8)2015-04  Estrogen Activates TAZ via GPER in Invasive Ductal Breast Carcinoma,2015全国生物化学与分子生物学会大会,深圳
9)2015-06  Acetylation of MAT IIα Represses Tumor Cell Growth and is Decreased in Human Hepatocellular Cancer ,第15届美洲华人生物科学学会SCBA国际学术研讨会,台北
10)2015-09  Acetylation of MAT IIα Represses Tumor Cell Growth and is Decreased in Human Hepatocellular Cancer,第11届海峡两岸细胞生物学学术研讨会,太原
11)2015-10  Estrogen Activates TAZ via GPER in Invasive Ductal Breast Carcinoma,第四届国际乳腺癌干细胞高峰论坛 ,苏州
12)2015-11  Protein degradation Controls Cancer Metabolism,第四届广州国际肿瘤学会议 , 广州
13)2015-12  Protein degradation Controls Cancer Metabolism,首届晋阳国际肿瘤前沿论坛, 太原
14)2015-12  Acetylation Control of Cancer Metabolism, 2015年国际代谢学会议, 上海
15)2016-05  Protein Degradation Controls Cancer Metabolism,中国(国际)首届微山湖肿瘤学高端论坛,济宁
16)2016-05  Protein Degradation Controls Cancer Metabolism,第九届中国蛋白质组学大会,厦门
17)2016-10  Acetylation Control of Lipid Synthesis, 中国生物化学与分子生物学会2016年全国学术大会, 杭州
18)2017-03  Acetate functions as an epigenetic metabolite to promote lipid synthesisunder hypoxia,第十二届海峡两岸细胞生物学学术研讨会,花莲
19)2017-09  Acetate functions as an epigenetic metabolite to promote lipid synthesisunder hypoxia,中英生命科学与医学高峰论坛 ,北京
20)2017-09  Acetate Functions as an Epigenetic Metabolite to Promote Lipid Synthesis under Hypoxia,第二届国际表观基因组学研讨会,上海
21)2017-10  Metabolites Promote Hepatocarcinoma Cancer Development,冷泉港亚洲会议 ,苏州
22)2018-3  Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer,冷泉港亚洲会议 ,苏州
23)2018-03  Acetyaltion Control of Lipid Synthesis, 皇后镇分子生物学会议, 上海,2018
24)2018-04  KRAS Stabilizes BCAT2 to Promote PDAC Initiation through BCAAs Catabolism, 中国细胞生物学会, 南京

发表论文(以第一或通讯作者发表,通讯作者以“*”标出,从2018年起倒序排列。选不超过10篇代表性论文用黄色高亮标出。)
1)Xia S, Lin R, Jin L, Zhao L, Kang HB, Pan Y, Liu S, Qian G, Qian Z, Konstantakou E, Zhang B, Dong JT, Chung YR, Abdel-Wahab O, Merghoub T, Zhou L, Kudchadkar RR, Lawson DH, Khoury HJ, Khuri FR, Boise LH, Lonial S, Lee BH, Pollack BP, Arbiser JL, Fan J*, Lei QY*, Chen J*. Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth. Cell Metabolism. 2017, 25(2):358-373
Highlights: Nature
2)Zhang Y, Xu YY, Yao CB, Li JT, Zhao XN, Yang HB, Zhang M, Yin M*, Chen J* Lei QY*. (2016). Acetylation targets HSD17B4 for degradation via CMA pathway in response to E1. Autophagy. 2017, 13(3):538-553.
3)Wang YP*,Wang J,Gao X, Xu YY, Cheng JK*, Lei QY*. Arginine Methylation of MDH1 by CARM1 Inhibits Non-canonical Glutamine Metabolism and Suppresses Pancreatic Cancer. Molecular Cell. 2016,64, 673–687
Highlights: Cancer discovery
4)Gao X, Lin SH,Ren F, Li1 JT, Chen JJ, Yao CB,Yang HB,Jiang SX, Yan GQ, Wang D, Wang Y, Liu Y, Cai Z, Xu YY, Chen J, Yu W, Yang YP*, Lei QY*. Acetate Functions as an Epigenetic Metabolite to Promote Lipid Synthesis under Hypoxia. Nature Commun. 2016 ;7:11960.
5)Zha Z, Han XR, Smith MD, Lei QY*, Guan KL*, Xiong Y*. Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination. Cell Discov. 2016 Apr 26;2:16005.
6)Han XR, Zha Z, Yuan HX, Feng X, Xia YK, Lei QY*, Guan KL*, Xiong Y*. KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation. Oncogene. 2016 Aug 11;35(32):4179-90.
7)Yang, HB., Xu, YY*., Zhao, XN, Zou SW*., Zhang Y., Zhang M., Li JT, Ren F., Wang LY., Lei QY*. Acetylation of MAT IIα  represses tumour cell growth and is decreased in human hepatocellularcancer. Nature Commun. 2015;Apr 30;6:6973.
8)Lv XB, Liu CY, Wang Z, Sun YP, Xiong Y*, Lei QY*, Guan KL*. PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction. EMBO Rep. 2015 Aug;16(8):975-85.
9)Zha, ZY., Han, XR., Matthew D. Smith, Liu, Y., Patrick M. Giguère, DraganaKopanja, PradipRaychaudhuri, David P. Siderovski, Guan, KL*, Lei, QY. *, and Xiong, Y*. A non- canonical function of Gβ as a subunit of E3 ligase in targeting GRK2 ubiquitylation. Molecular Cell. 2015;58(5):794-803
10)Zhou, X#., Wang, SY#., Wang, Z., Feng, X., Liu, P., Lv, X-B., Li, F-L., Yu, F-x., Sun,YP., Yuan, HX., Zhu, HG, Xiong,Y*, Lei, QY*, Guan, KL*. Estrogen Activates TAZ via GPER in Invasive Ductal Breast Carcinoma. J Clin Invest. 2015;125(5):2123-35.
11)Xu Y, Li F, Lv L, Li T, Zhou X, Deng CX, Guan KL*, Lei QY*, Xiong Y*. Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase. Cancer Res. 2014 Jul 1;74(13):3630-42.
12)Zhao, D., Mo, Y., Li, MT., Zou,SW., Cheng, ZL., Sun, Y-P., Xiong, Y*, Guan, KL*, Lei, QY*. NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin Invest. 2014;124(12):5453-65.
13)Li T, Liu F, Feng X, Wang Z, Das I, Xu Y, Zhou X, Sun Y, Guan KL, Xiong Y, Lei QY*. Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal. J. Biol. Chem. 2014;289(6):3775-85.
14)Lv L, Xu Y, Zhao D, Li F, Wang W, Sasaki N, Jiang Y, Zhou X, Li T, Guan KL*, Lei QY* and Xiong Y*. Mitogenic and oncogenic stimulation of K433 acetylation promote PKM2 protein kinase activity and nuclear localization. Molecular Cell. 2013;52, 340–352. (Cover story in Molecular cell)
Highlights:Nature Review in Cancer and Cancer discovery
15)Lin R, Ren T, Gao X, Zhou X, Li T, Xiong Y, Guan KL, Lei QY*. Acetylation Stabilizes ATP- citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth. Molecular Cell. 2013;51, 506–518.
16)Zhao D, Zou S, Liu Y, Zhou X, Mo Y, Wang P, Xu Y, Dong B, Xiong Y*, Lei QY* and Guan KL*., Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer. Cancer Cell. 2013;23, 464-476.
17)Huang W, Lv X, Liu C, Zha Z, Zhang H, Jiang Y, Xiong Y, Lei QY*, Guan KL*. The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. J Biol Chem. 2012 Jul 27;287(31):26245-53.
18)Zhou X, Li T, Feng X, Hsiang E, Xiong Y, Guan KL , Lei QY*. Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage. Biochem J. 2012; 441(1): 227-36.
19)Lv L, Li D, Zhao D, Lin R, Chu Y,Zhang H, Zha Z, Ying Liu, Li Z, Xu Y, Huang Y, Gang W, Xiong Y, Guan KL, and Lei QY*. Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth. Molecular Cell. 2011;42, 719-730.  (Feature Article )
Highlights:Preview in Molecular Cell, Science Signaling, and Faculty of 1000
20)Liu CY, Lv X, Li T, Xu Y, Zhou X, Zhao S, Xiong Y, Lei QY*, Guan KL*. PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ. J Biol Chem. 2011 Feb 18;286(7):5558-66.
21)Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY*, Guan KL*. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem. 2009 May 15;284(20):13355-62.
22)Lei QY*, Zhang H, Zhao B, Zha ZY, Bai F, Pei XH, Zhao S, Xiong Y*, Guan KL.TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway.Mol Cell Biol. 2008 Apr;28(7):2426-36.
23)Lei Q, Jiao J, Xin L, Chang CJ, Wang S, Gao J, Gleave ME, Witte ON, Liu X, Wu H*. NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. Cancer Cell. 2006 May;9(5):367-78.
24)Ke X1, Lei Q, James SJ, Kelleher SL, Melnyk S, Jernigan S, Yu X, Wang L, Callaway CW, Gill G, Chan GM, Albertine KH, McKnight RA, Lane RH. Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats. Physiol Genomics. 2006 Mar 13;25(1):16-28. (共同第一作者)
25)Lei QY, Wang LY, Dai ZY, Zha XL. The relationship between PTEN expression and anoikis in human lung carcinoma cell lines. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2002 Jul;34(4):463-8.


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