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教授
蔡启良
发表时间:2013-03-20 阅读次数:9306次

    蔡启良,男,1976年10月生,福建晋江人,复旦大学基础医学院教育部卫生部医学分子病毒重点室研究员、博士生导师。中国医学科学院/北京协和医大学病原生物学博士。2004-2012年任美国宾夕法尼亚大学医学院和约伯翰逊综合性肿瘤中心博士后和助理研究员,2012年以人才引进和独立PI回复旦工作至今。长期从事“致瘤性病毒持续感染、与微环境应激共致癌分子机制及相关皮肤血液疾病的诊治应用”研究,在国际权威刊物PLoS Pathog、J Virol和Vaccine等发表了SCI文章40余篇(第一和通讯作者为主,篇均IF=5.16,他引近千次),申请国内外专利5项授权2项(PCT/CN03/00620,CN2004100809826),参编英文专著2部。有关研究成果受到了Science Daily,Faculty of 1000,Penn Medicine等国际学术期刊或媒体多次报道和评述。获国家自然科学基金、国家重大基础研究973子课题、教育部新世纪优秀人才计划和上海市教委创新计划重点项目等资助。美国肿瘤研究协会和微生物协会永久会员;中华医学会医学病毒分会委员;中国微生物学会病毒青年分会副主任委员;任PLoS One、J Pharma Pharmacol等国际杂志编委Editor;国家自然科学基金、留学基金和科技进步奖评审专家。

 

近年发表主要文章(*通讯作者):

1.        Cai Q*, Cai S, Zhu C, Verma SC, Choi JY, Robertson ES* (2013). A SUMO2-interacting motif within LANA is essential for KSHV latency. PLoS Pathogens, 9(10):e1003751.

2.        Cai Q*, Shuovomoy A, Cervini A, Lu J, Hislop AD, Dzeng R, Robertson ES* (2013). IRF4-mediated CIITA transcription is blocked by KSHV encoded LANA to inhibit MHC II presentation. PLoS Pathogens, 9(10):e1003750.

3.        Banerjee S, Lu J, Cai Q, Saha A, Jha HC, Robertson ES (2013). The EBV latent antigen 3C inhibits apoptosis through targeted regulation of interferon regulatory factors 4 and 8. PLoS Pathogens, 9(5):e1003314

4.        Cai Q, Xiao B, Si H, Cervini A, Gao J, Lu J, Robertson ES (2012). Kaposi’s sarcoma herpesvirus upregulates Aurora A kinase to promote phosphorylation-dependent ubiquitylation of p53. PLoS Pathogens, 8(3): e1002566.  

5.        Cai Q, Guo Y, Xiao B, Banerjee S, Saha A, Lu J, Glisovic T, Robertson ES (2011). Epstein-Barr virus nuclear antigen 3C stabilizes Gemin3 to block p53-mediated apoptosis. PLoS Pathogens, 7(12):e1002418.  

6.        Lu J, Verma SC,  Cai Q, Saha A, Dzeng R, Robertson ES (2011). The RBP-Jκ binding sites within the RTA Promoter Regulates KSHV Latent Infection and Proliferation. PLoS pathogens, 8(1):e1002479.

7.        Verma SC, Lu J, Cai Q, Kosiyatrakul S, McDowell M, Schildkraut CL, Robertson ES (2011). Single molecule analysis of replicated DNA reveals the usage of mutiple KSHV genome regions for latent replication. PLoS pathogens, 7(11):e1002365.

8.        Saha A, Halder S, Upadhayay S, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES (2011). EBNA3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1. PLoS Pathogens, 7(2):e1001275.

9.        Cai Q, Verma SC, Choi JY, Ma M, Robertson ES (2010). Kaposi’s sarcoma associated herpesvirus inhibites IL-4-mediated STAT6 phosphorylation to regulate apoptosis and maintain latency. Journal of Virology, 84(21):11134-11144.

10.    Cai Q, Verma SC, Kumar P, Ma M, Robertson ES (2010). Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification. PLoS ONE, 5(3): e9720.  

(News reports about the research featured at the following links:

http://news.pennmedicine.org/news-bites/2010/06/tumor-suppressor-protein-tag-suggests-new-therapy.html

Recommended by Faculty of 1000 Biology:

http://f1000biology.com/article/id/2743956/evaluation )

11.    Cai Q, Verma SC, Lu J, Robertson ES (2010). Molecular biology of Kaposi’s sarcoma-associated herpesvirus and related oncogenesis. Advances in Virus Research, 78:87-142.

12.    Cai Q, Knight JS, Verma SC, Zald P, Robertson ES (2006). EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of VHL and p53 tumor suppressors. PLoS Pathogens, 2(10): e116.  

(News reports about the research featured at the following links:

http://www.uphs.upenn.edu/news/News_Releases/nov06/KSHV.htm

http://www.sciencedaily.com/releases/2006/11/061108154410.htm

http://www.med.upenn.edu/micro/whats_new_items/item104.html )

 

 

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