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教授
汤其群
发表时间:2013-03-27 阅读次数:15839次
姓名:汤其群 博士职称:教授

 

E-MAIL:qqtang@shmu.edu.cn

WWW: http://www.------

 

 

 

 

研究方向
1.  白色及米色脂肪细胞的分化发育调控    
2.  代谢性疾病发生的机制
 

重要学术贡献
1.系统阐明间充质干细胞定向为前脂肪细胞,及前脂肪细胞发育为成熟脂肪细胞的分子机制;
2.阐明米色脂肪发育的调控机制,特别是BMP4及BMP信号通路对米色脂肪发育的调控作用;
3.鉴定了一系列通过激活米色脂肪发育进而改善机体代谢的小分子化合物,为针对肥胖及代谢综合征开发相关药物奠定基础。

荣誉与获奖
1.2015年中国糖尿病研究进展奖                                       2016年
2.复旦大学研究生心目中的好导师                                     2016年
3.教育部高等学校优秀科技成果奖                                     2015年
脂肪细胞发育分化的分子机制                                           自然科学奖二等奖     第一完成人
4.全国优秀科技工作者                                                      2012年
5.上海市“育才”奖                                                             2011年
6.复旦大学优秀研究生导师                                              2011年
7.复旦大学上海医学院杰出贡献奖                                    2011年
8.复旦大学教学名师                                                         2011年
9.CMB(中华医学基金会 China Medical Board)            杰出教授奖  2010年
10.谈家桢生命科学创新奖                                                2010年
11.入选国家“新世纪百千万人才工程”国家级人选              2009年
12.复旦大学上海医学院院长奖银奖                                  2009年
13.复旦大学廖凯原“最受欢迎教师奖”                                2008年
14.复旦大学上海医学院杰出贡献奖                                   2008年
15.复旦大学校长奖  2008年
16.上海市领军人才(上海市人事局)                               2007年
17.明治乳业生命科学奖 优秀奖                                        2007年
18.2002年霍英东教育基金会优秀青年教师一等奖
19.重组链激酶(r-SK)的研制、开发与临床应用
1999年卫生部科学技术进步一等奖   第四完成人  
1999年上海市科学技术进步一等奖   第四完成人
2000年国家科学技术进步二等奖     第四完成人
2000年杜邦科技创新奖             第四完成人
20.    一种制备重组链激酶的方法   
1999年中国专利金奖              第二完成人
21.    注射用重组葡激酶(r-SaK)的研制   
1994年上海市科学技术进步三等奖    第二完成人

国内外学术团体任职
2014.8-2018.8         中国生物化学与分子生物学会第十一届理事会副理事长
2016年至今              中国生物化学与分子生物学会代谢专业委员会主任委员
2015.04-2020.09     Journal of Biological Chemistry 编委
2017.09至今            Journal of Biological Chemistry副主编
    

受邀审稿学术刊物
2010-今        Nature communication,Diabetes,PNAS,JBC,MCB等

校内学术机构任职
代谢分子医学教育部重点实验室主任

受邀学术报告
2017,BMP4 Cross-talks With Estrogen/ERα Signaling to Regulate Adiposity and Glucose Metabolism in Females,CSH Asia conference
……
发表论文
1.Wei XB, Guo L, Liu Y, Zhou SR, Liu Y, Dou X, Du SY, Ding M, Peng WQ, Qian SW, Huang HY, Tang QQ*.Synthesis of cytochrome c oxidase 1 (SCO1) inhibits insulin sensitivity by decreasing copper levels in adipocytes. Biochem Biophys Res Commun. 2017 Sep 23;491(3):814-820
2.Liu Y, Du SY, Ding M, Dou X, Zhang FF, Wu ZY, Qian SW, Zhang W, Tang QQ*, Xu CJ*. The BMP4-Smad Signaling Pathway Regulates Hyperandrogenism Development in a Female Mouse Model. J Biol Chem. 2017 Jun 1
3.Zhou SR, Guo L, Wang X, Liu Y, Peng WQ, Liu Y, Wei XB, Dou X, Ding M, Lei QY, Qian SW, Li X, Tang QQ*. Acetylation of Cavin-1 Promotes Lipolysis in White Adipose Tissue. Mol Cell Biol. 2017 May 30.
4.Lu P, Zhang FC, Qian SW, Li X, Cui ZM, Dang YJ, Tang QQ*. Artemisinin derivatives prevent obesity by inducing browning of WAT and enhancing BAT function. Cell Res. 2016 Oct;26(10):1169-1172.
5.Chen SZ, Ning LF, Xu X, Jiang WY, Xing C, Jia WP, Chen XL, Tang QQ*, Huang HY. The miR-181d-regulated metalloproteinase Adamts1 enzymatically impairs adipogenesis via ECM remodeling. Cell Death Differ. 2016 Nov 1;23(11):1778-1791.
6.Guo L, Zhou SR, Wei XB, Liu Y, Chang XX, Liu Y, Ge X, Dou X, Huang HY, Qian SW, Li X, Lei QY, Gao X, Tang QQ*. Acetylation of Mitochondrial Trifunctional Protein α-Subunit Enhances Its Stability To Promote Fatty Acid Oxidation and Is Decreased in Nonalcoholic Fatty Liver Disease. Mol Cell Biol. 2016 Sep 26;36(20):2553-67.
7.Chen SZ, Xu X, Ning LF, Jiang WY, Xing C, Tang QQ, Huang HY*. (2015) miR-27 impairs the adipogenic lineage commitment via targeting lysyl oxidase. Obesity 2015 Dec;23(12):2445-53
8.Yan Tang, Shu-wen Qian*, Jue Wang, Meng-yuan Wu, Ping Lu, Xi Li, Hai-yan Huang, Liang Guo, Xia Sun, Cong-jian Xu, Qi-qun Tang*,BMP4 mediates the interplay between adipogenesis and angiogenesis during expansion of subcutaneous white adipose tissue. Journal of Molecular Cell Biology
9.Yang Liu, Xin Ge, Xin Dou, Liang Guo, Yuan Liu, Shui-rong Zhou, Xiang-bo Wei, Shu-wen Qian, Hai-yan Huang, Cong-jian Xu, Wei-Ping Jia, Yong-jun Dang, Xi Li, and Qi-Qun Tang* .(2015)Protein Inhibitor of Activated STAT 1 (PIAS1) Protects Against Obesity-Induced Insulin Resistance by Inhibiting Inflammation Cascade in Adipose Tissue. Diabetes 2015; 64(12): 4061-74
10.Zhi-Chun Zhang, Yan Liu, Liu-Ling Xiao, Shu-Fen Li, Jing-Hui Jiang, Yue Zhao, Shu-Wen Qian, Qi-Qun Tang, Xi Li* (2015) Up-regulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice. Journal of Hepatology, 2015; 63: 1466-1475
11.Liu-Ling Xiao, Xu-Guang Yang, Yu-Li Lin, Shu-Fen Li, Jin-Hui Jiang, Shu-Wen Qian, Qi-Qun Tang, Rui He* and Xi Li*,(2015) Large adipocytes function as antigen-presenting cells to activate CD4+ Q1 T cells via upregulating MHCII in obesity. International Journal of Obesity (2015), 1–9
12.Huang HY*, Zhang WT, Jiang WY, Chen SZ, Liu Y, Ge X, Li X, Dang YJ, Wen B, Liu XH, Lu HJ, Qi-Qun Tang* .(2015) RhoGDIβ Inhibits Bone Morphogenetic Protein 4 (BMP4)-induced Adipocyte Lineage Commitment and Favors Smooth Muscle-like Cell Differentiation. J Biol Chem. 2015 Apr 24;290(17):11119-29
13.Guo L, Li X, Qi-Qun Tang*.(2015) Transcriptional regulation of adipocyte differentiation: a central role for CCAAT/enhancer-binding protein (C/EBP) β. J Biol Chem. 2015 Jan 9;290(2):755-61
14.Yan Jiang, Liang Guo, Li-Qi Xie, You-You Zhang, Xiao-Hui Liu, Yang Zhang, Hao Zhu, Peng- Yuan Yang, Hao-Jie Lu, Qi-Qun Tang*. (2014) Proteome profiling of mitotic clonal expansion during 3T3-L1 adipocyte differentiation using iTRAQ-2DLC-MS/MS. J. Proteome Res. 2014 Mar 7;13(3):1307-14.
15.Zhichun Zhang, Liu, Y.; Shu-Fen Li, Liang Guo, Yue Zhao, Shu-Wen Qian, Bo Wen, Qi-Qun Tang, Xi Li*, (2014) Suv39h1 Mediates AP-2alpha-Dependent Inhibition of C/EBPalpha Expression during Adipogenesis. Mol Cell Biol, 34 (12), 2330-2338
16.Xi Li, Rong Zeng, Qi-Qun Tang*, (2014) Evaluation of protein phosphorylation during adipogenesis. Methods in Enzymology , 538:279-295
17.Yue Zhao, Ya-Dong Zhang, You-You Zhang, Shu-Wen Qian, Zhi-Chun Zhang, Shu-Fen Li, Liang Guo, Yuan Liu, Bo Wen, Qun-Ying Lei Qi-Qun Tang, Xi Li*, (2014) p300-Dependent Acetylation of ATF5 Enhances C/EBPβ Transactivation of C/EBPα During 3T3-L1 Differentiation. Mol Cell Biol. 34(3):315-324
18.Yang Liu, Ya-Dong Zhang, Liang Guo, Hai-Yan Huang, Hao Zhu, Jia-Xin Huang, Yuan Liu, Shui-Rong Zhou, Yong-Jun Dang, Xi Li, Qi-Qun Tang*, Protein Inhibitor of Activated STAT 1 (PIAS1) Is Identified as the SUMO E3 Ligase of CCAAT/Enhancer- Binding Protein β (C/EBPβ) during Adipogenesis. Mol Cell Biol. 2013 Nov;33(22): 4606-17
19.Liang Guo, Jia-Xin Huang,Yang Liu,Xi Li,Shui-Rong Zhou, Shu-Wen Qian, Yuan Liu, Hao Zhu, Hai-Yan Huang, Yong-Jun Dang, Qi-Qun Tang*,(2013) Transactivation of Atg4b by C/EBPβ promotes autophagy to facilitate adipogenesis. Mol Cell Biol. 33(16):3180-90
20.Shan-Shan Wang, Hai-Yan Huang, Su-Zhen Chen, Xi Li, Yuan Liu, Wen-Ting Zhang, Qi-Qun Tang* (2013) Early growth response 2 (Egr2) plays opposing roles in committing C3H10T1/2 stem cells to adipocytes and smooth muscle-like cells. Int J Biochem Cell Biol. 45(8):1825-32
21.Shan-Shan Wang, Hai-Yan Huang, Su-Zhen Chen, Xi Li, Wen-Ting Zhang, Qi-Qun Tang* (2013) Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage FEBS J. 2013Jun; 280(11):2644-51
22.Shu-fen Li, Liang Guo, Shu-wen Qian, Yuan Liu, You-You Zhang, Zhi-Chun Zhang, Yue Zhao, Jian-Yong Shou, Qi-Qun Tang, Xi Li*,(2013) G9a is transactivated by C/EBPβ to facilitate mitotic clonal expansion during 3T3-L1 preadipocyte differentiation. Am J Physiol Endocrinol Metab, 304(9): E990-998
23.Yuan Liu, Zhi-Chun Zhang, Shu-Wen Qian, You-you Zhang, Hai-yan Huang, Yan Tang, Liang Guo, Xi Li, and Qi-Qun Tang*, (2013)MicroRNA-140 promotes adipocyte lineage commitment of C3H10T1/2 pluripotent stem cell via targeting Osteopetrosis-associated transmembrane protein 1. J. Biol. Chem. 288(12): 8222-30
24.Shu-wen Qian, Yan Tang, Xi Li, Yuan Liu, You-you Zhang, Hai-yan Huang, Rui-Dan Xue, Hao-yong Yu, Liang Guo, Hui-di Gao, Yan Liu, Xia Sun, Yi-ming Li, Wei-Ping Jia, Qi-Qun Tang*, (2013) BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc Natl Acad Sci USA. 110(9): E798-807
25.Hai-Yan Huang, Su-Zhen Chen, Wen-Ting Zhang, Shan-Shan Wang, Yang Liu, Xi Li, Xia Sun, Yi-Ming Li, Bo Wen, Qun-Ying Lei,Qi-Qun Tang*,(2013)Induction of EMT-like response by BMP4 via up-regulation of lysyl oxidase is required for adipocyte lineage commitment. Stem Cell Research. 10(3): 278-287
26.Liang Guo, Xi Li, Jia-Xin Huang, Hai-Yan Huang, You-You Zhang, Shu-Wen Qian, Hao Zhu, Ya-Dong Zhang, Yang Liu, Yuan Liu, Kan-Kan Wang, Qi-Qun Tang*, (2012) Histone Demethylase Kdm4b Functions as a Co-Factor of C/EBPβ to Promote Mitotic Clonal Expansion During Differentiation of 3T3-L1 Preadipocytes. Cell Death Differ.  19(12): 1917-1927.
27.Qi-Qun Tang, M. Daniel Lane, (2012) Adipogenesis: From stem cell to adipocyte. Annu Rev Biochem. 81:21.1-21.22.
28.You-you Zhang, Xi Li, Shu-wen Qian, Liang Guo, Hai-yan Huang, Qun He, Yuan Liu, Chun-Gu Ma, and Qi-Qun Tang*, (2012) Down-regulation of type I runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis. Mol Endocrinol. 26(5): 798-808.
29.Qun He, Hai-yan Huang, You-you Zhang, Xi Li, Shu-wen Qian, Qi-Qun Tang*, (2012) TAZ is downregulated by dexamethasone during the differentiation of 3T3-L1 preadipocytes. Biochem Biophys Res Commun. 419(3): 573-7.
30.Yuan-yuan Zhang, Shu-fen Li, Shu-wen Qian, You-you Zhang, Yuan Liu, Qi-Qun Tang, Xi Li, (2012) Phosphorylation prevents C/EBPβ from the calpain-dependent degradation. Biochem Biophys Res Commun. 419(3): 550-5.
31.You-You Zhang, Xi Li, Shu-Wen Qian, Liang Guo, Hai-Yan Huang, Qun He, Yuan Liu, Chun-Gu Ma, and Qi-Qun Tang*, (2011) Transcriptional activation of histone H4 by C/EBP during the mitotic clonal expansion of 3T3-L1 adipocyte differentiation. Mol Biol Cell, 22: 2165-74.
32.Hai-Yan Huang, Ling-Ling Hu, Tan-Jing Song, Xi Li, Qun He, Xia Sun, Yi-Ming Li, Hao-Jie Lu, Peng-Yuan Yang, and Qi-Qun Tang* (2011) Involvement of cytoskeleton-associated proteins in the commitment of C3H10T1/2 pluripotent stem cells to adipocyte lineage induced by BMP2/4. Mol Cell Proteomics 10(1): 1-8.
33.Shu-wen Qian, Xi Li You-You Zhang, Hai-yan Huang, Yuan Liu, Xia Sun, Qi-Qun Tang*. (2010) Characterization of adipocyte differentiation from human mesenchymal stem cells in bone marrow. BMC Developmental Biology. 10:47.
34.Haiyan Huang, Tan-Jing Song, Xi Li, Lingling Hu, Qun He, Mei Liu, M. Daniel Lane, Qi-Qun Tang*(2009) The BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage, Proc Natl Acad Sci USA. 106: 12670-5.
35.Xi Li, Henrik Molina, Haiyan Huang, You-you Zhang, Mei Liu, Shu-wen Qian, Chad Slawson, Wagner B. Dias, Akhilesh Pandey, Gerald W. Hart, M. Daniel Lane, Qi-Qun Tang* (2009) O-linked N-acetylglucosamine modification on C/EBP role during adipocyte differentiation, J. Biol. Chem., 284: 19248-19254.
36.Molina H, Yang Y, Ruch T, Kim JW, Mortensen P, Otto T, Nalli A, Tang QQ, Lane MD, Chaerkady R, Pandey A.(2009)Temporal profiling of the adipocyte proteome during differentiation using a five-plex SILAC based strategy. J Proteome Res. 8(1):48-58.
37.Hai-Yan Huang, Xi Li, Mei Liu, Tanjing Song, Qun He, Chungu Ma, Qi-Qun Tang* (2008) Transcription factor YY1 promotes adipogenesis via inhibiting CHOP-10 expression. Biochem Biophys Res Commun. 375: 496-500.
38.Lin Jiang, Naixian Zhang, Wei Mo, Rui Wan, Chungu Ma, Xi Li, Yinliang Gu, Xinying Yang, Qi-Qun Tang, Houyan Song (2008) Rehmannia inhibits adipocyte differentiation and adipogenesis, Biochem Biophys Res Commun. 371(2): 185-190.
39.Deguo Liu, Honglei Liu, Tanjing Song, Haiyan Huang, Xi Li, Qi-Qun Tang*, (2007) Functional expression of the globular domain of human adiponectin in Pichia pastoris. Biochem Biophys Res Commun. 363(3): 769-775.
40.Xi Li, Jae-Woo Kim, Mads Gronborg, Henning Urlaub,M Daniel Lane, Qi-Qun Tang, (2007) Role of cdk2 in the Sequential Phosphorylation/activation of C/EBP during adipocyte differentiation. Proc Natl Acad Sci USA. 104: 11597-602.
41.Jianyong Liu, Heather Martin, Meir Shamay, Crystal Woodard, Qi-Qun Tang, S. Diane Hayward, (2007) Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiation. J Virol. 81: 4722-4731.
42.Jae-Woo Kim, Qi-Qun Tang, Xi Li, M Daniel Lane, (2007) DNA binding and transcriptional activation by C/EBP beta: effect of phosphorylation and S-S bond-induced dimerization. Proc Natl Acad Sci USA. 104: 1800-4.
43.Xi Li, Hai-Yan Huang, Jie-Gen Chen, Lin Jiang, Hong-Lei Liu, De-Guo Liu, Tan-Jing Song, Qun He, Chun-Gu Ma, Duan Ma , Qi-Qun Tang* . (2006) Lactacystin inhibits 3T3-L1 adipocyte differentiation through induction of CHOP-10 expression. Biochem Biophys Res Commun. 350(1): 1-6.
44.Jie-Gen Chen, Xi Li, Hai-Yan Huang, Hong-Lei Liu, De-Guo Liu, Tan-Jing Song, Chun-Gu Ma, Duan Ma,Hou-Yan Song and Qi-Qun Tang* (2006) Identification of a peroxisome proliferator responsive element (PPRE)-like cis-element in mouse plasminogen activator inhibitor-1 gene promoter . Biochem Biophys Res Commun. 347(3): 821-6.
45.Haiyan Huang, M. Daniel Lane , Qi-Qun Tang*,. (2005) Effect of serum on  Down-regulation of CHOP-10 during Differentiation of 3T3-L1 Preadipocytes . Biochem Biophys Res Commun. 338 (2): 1185-1188.
46.Qi-Qun Tang, Gronborg M, Huang H, Kim JW, Otto TC, Pandey A, Lane MD, (2005) Sequential phosphorylation of CCAAT enhancer-binding protein {beta} by MAPK and glycogen synthase kinase 3{beta} is required for adipogenesis.Proc Natl Acad Sci U S A. 102(28): 9766-71.
47.Lane MD, Qi-Qun Tang, (2005) From multipotent stem cell to adipocyte. Birth Defects Res A Clin Mol Teratol. 73(7):476-477.
48.Huang GC, Zhang JS, Qi-Qun Tang. (2004) Involvement of C/EBP-alpha gene in in vitro activation of rat hepatic stellate cells. Biochem Biophys Res Commun. 324(4): 1309-18.
49.Qi-Qun Tang, Otto TC, Lane MD. (2004) Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci U S A. 101(26): 9607-11.
50.Qi-Qun Tang, Zhang JW, Daniel Lane M. (2004) Sequential gene promoter interactions by C/EBPbeta, C/EBPalpha, and PPARgamma during adipogenesis. Biochem Biophys Res Commun. 318(1): 213-8.
51.Zhang JW, Qi-Qun Tang, Vinson C, Lane MD. Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci U S A. 2004 Jan 6;101(1): 43-7
52.Qi-Qun Tang, CO Tamara, and MD Lane. CCAAT/enhancer-binding proteinβ is required for mitotic clonal expansion during adipogenesis. Proc.Natl.Acad. Sci. USA. 2003; 100: 850-855.
53.Qi-Qun Tang, CO Tamara , and MD Lane. Mitotic clonal expansion: A synchronous process required for adipogenesis. Proc.Natl.Acad. Sci. USA. 2003; 100: 44-49.
54.Wu FY, Wang SE, Qi-Qun Tang, Fujimuro M, Chiou CJ, Zheng Q, Chen H, Hayward SD, Lane MD, Hayward GS. Cell cycle arrest by Kaposi's sarcoma-associated herpesvirus replication-associated protein is mediated at both the transcriptional and posttranslational levels by binding to CCAAT/enhancer-binding protein alpha and p21 (CIP-1). J Virol. 2003 Aug; 77(16):8893-914.
55.YW Frederick, Qi-Qun Tang, and S Gary. Hayward. Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus caused P21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-α. Proc.Natl.Acad. Sci. USA. 2002; 99:10683-10688.
56.Qi-Qun Tang, and MD Lane. Role of C/EBP homologous protein (CHOP-10) in the programmed activation of CCAAT/enhancer-binding protein-β during adipogenesis. Proc.Natl.Acad. Sci. USA. 2000; 97, 12446-12450.
57.MD Lane, Qi-Qun Tang, and MS Jiang. Role of the CCAAT enhancer binding proteins(C/EBPs) in adipocyte differentiation. Biochem Biophys Res Comnmun. 1999; 266(3):677-83.
58.Qi-Qun Tang, and MD Lane. Activation and centromeric localization of C/EBP’S during the mitotic clonal expansion of adipocyte differentiation. Genes & Development. 1999; 13(17): 2231-2241.
59.Qi-Qun Tang, MS Liang and MD Lane. Repressive Effect of Sp1 on the C/EBPαGene Promoer: Role in Adipocyte. Mol. Cell. Biology. 1999; 19(7), 4855-4865.
60.MD Lane, Qi-Qun Tang, and MS Jiang. The Adipocyte Differentiation Program: Repression/Derepression of C/EBPα Gene .  J. Animal. Science. 1999; 77, (suppl.3), 23-32.
61.MD Lane, MS Jiang and Qi-Qun Tang. Role of C/EBPαin Adipocyte Differentiation. Proceding of Penningtion Syposium on Nutrition Genetics and Obesity,  Ed. by G, Bray and D. Ryan, LSU Press, Balton Rouge, LA. 1998 pp459-475.
62.MS Jiang, Qi-Qun Tang, J McLenithan, W Schillinglaw, W Henzel and MD Lane. Depression of the C/EBPαGene During Adipogenesis:Identification of Ap-2α as a Repressor.  Proc. Natl. Acad. Sci. USA, 1998; 95, 3467-3471.
63.Qi-Qun Tang, MS Jiang, and MD Lane. Repression of Transcription Mediated by Dural Elements in CCAAT/enhancer Binding Protein α Gene.  Proc. Nalt. Acad. Sci. USA. 1997; 94, 13571-13575.
64.CH Zhan, ZL Wan, WR Chang, JJ Yue, DC Liang, Qi-Qun Tang, YL Gu, XX Zhang, G Xu, YS Zhu, HY Song, Crystallization and preliminary X-ray diffraction studies of recombinant staphylokinase, Acta Cryst. 1996; D52: 564-565.

学术专著
2015.04-2020.09  Journal of Biological Chemistry 编委
2017.09至今 Journal of Biological Chemistry副主编

申请或授权专利
授权专利

1. 一种重组葡激酶的制备方法(中国)              1997
2. 一种制备重组链激酶的方法(中国)              1996
一种制备重组链激酶的方法(瑞士)                  1997
一种制备重组链激酶的方法(俄罗斯)               1997
3. 地黄提取物及其制备方法和应用 (中国)       2005  第二完成人
专利号:200510025128.4
4. 一种N末端缺失脂肪细胞补体相关蛋白及其制备方法 2005 第一完成人
专利号:ZL01126950.2
5. 一种多肽gapM1及其制备方法(2011) 第一完成人
专利号:200510025128.4

申请专利
蒿甲醚在制备促进脂肪分解和改善糖代谢制剂中的用途,201610305363.5
,第一完成人
 

 

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