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教授
邓强
发表时间:2018-05-04 阅读次数:2219次

姓名:邓强 博士
职称:研究员
E-MAIL: qdeng@fudan.edu.cn
 

 

 

 

研究方向
(1)慢性病毒性肝炎病理机制
(2)乙型肝炎病毒(HBV)持续感染实验小鼠模型
(3)新型主动免疫策略清除病毒持续感染

重要学术贡献
(1)首次建立HBV重组cccDNA体外培养细胞和小鼠实验模型,成为高效的药物筛选平台,同时也代表了一种原型策略诱导病毒持续性感染
(2)揭示了HBV核心蛋白可能的病理意义,并藉此发展了重症肝炎相关实验小鼠模型
(3)创新性设计和发展了一种基于外源性抗原T细胞应答的免疫治疗概念,代表了打破免疫耐受、清除慢性HBV感染的有效策略

荣誉与获奖
2010    中国科学院上海生命科学院Sanofi-Aventis优秀青年人才奖
2010    中国科学院卢嘉锡青年人才奖

国内外学术团体任职
2012-今        上海市医学会医学病毒专业分会委员

受邀审稿学术刊物
2010-今        Hepatology,J Hepatol,PLoS Pathogens,PLoS ONE,Sci Rep,Front Immunol,J Med Virol,以及Virol J等

校内学术机构任职


受邀学术报告
2014    “Foreign antigen-mediated T cell response against hepatitis B virus infection: mouse model-based studies”, 亚太肝脏研究协会年会(APASL),广州
2017    “Recombinant cccDNA of hepatitis B virus induces long-term viral persistence with chronic hepatitis in a mouse model”, 2017 国际HBV分子生物学年会,华盛顿

发表论文
1.Li G, Zhu Y, Shao D, Chang H, Zhang X, Zhou D, Gao Y, Lan K*, Deng Q*. Recombinant covalently closed circular DNA of hepatitis B virus induces long-term viral persistence with chronic hepatitis in a mouse model. Hepatology. 2018; 67(1): 56-70.
2.Jia B, Guo M, Li G, Yu D, Zhang X, Lan K*, Deng Q*. Hepatitis B core protein sensitizes hepatocytes to tumor necrosis factor-induced apoptosis by suppression of the phosphorylation of mitogen-activated protein kinase kinase 7. J Virol. 2015; 89(4): 2041-51.
3.Qi Z, Li G, Hu H, Yang C, Zhang X, Leng Q, Xie Y, Yu D, Zhang X, Gao Y, Lan K*, Deng Q*. Recombinant covalently closed circular hepatitis B virus DNA induces prolonged viral persistence in immunocompetent mice. J Virol. 2014; 88: 8045-56.
4.Wang Z, Zhu K, Bai W, Jia B, Hu H, Zhou D, Zhang X, Zhang X, Xie Y, Bourgine MM, Michel ML, Lan K*, Deng Q*. Adenoviral delivery of recombinant hepatitis B virus expressing foreign antigenic epitopes for immunotherapy of persistent viral infection. J Virol. 2014; 88:3004-3015.
5.Gao DY, Jin GD, Yao BL, Zhang DH, Gu LL, Lu ZM, Gong QM, Lone YC, Deng Q*, Zhang XX*. Characterization of the specific CD4+ T cell response against the F protein during chronic hepatitis C virus infection. PLoS One. 2010. 5(12) e14237.
6.Deng Q, Mancini-Bourgine M, Zhang X, Cumont MC, Zhu R, Lone YC, Michel ML. Hepatitis B virus as a gene delivery vector activating foreign antigenic T cell response that abrogates viral expression in mouse models. Hepatology. 2009; 50: 1380-91.
7.Deng Q, Zhai JW, Michel ML, Zhang J, Qin J, Kong YY, Zhang XX, Budkowska A, Tiollais P, Wang Y, Xie YH. Identification and characterization of peptides that interact with hepatitis B virus via the putative receptor binding site. J Virol. 2007; 81: 4244-54.
8.Deng Q, Zhuang M, Kong YY, Xie YH, Wang Y. Screening for PreS specific binding ligands with a phage displayed peptides library. World J Gastroenterol. 2005; 11(26): 4018-23.
9.Deng Q, Kong YY, Xie YH, Wang Y. Expression and purification of the complete PreS region of hepatitis B Virus. World J Gastroenterol. 2005; 11(20): 3060-4.

学术专著


申请或授权专利
授权专利
1.Deng Q, Michel ML. Polynucleotides allowing the expression and secretion of recombinant pseudo-virus containing foreign epitopes, their production, and use. 2013, US: US8343757 B2
2.汪垣,谢幼华,邓强。人乙型肝炎病毒表面抗原大蛋白前表面抗原区结合肽及其用途。2007,中国:CN100341890 C

申请专利
1.邓强,蓝柯,谢幼华,汪垣,齐治华,李改云。制备HBV持续感染模型的试剂和方法。2013:专利申请号 201310280198.9
 

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