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教授
顾宏周
发表时间:2018-05-07 阅读次数:2313次

    

 

姓名:顾宏周 博士
职称:研究员
E-MAIL: hongzhou.gu@fudan.edu.cn
WWW: http://ibs.fudan.edu.cn/peoplemore.php?id=300&tid=1

研究方向
1.DNA纳米编辑技术
2.适配体及其衍生物的发现和传感应用
3.多功能核酸纳米组装体的仿生学应用

重要学术贡献
本人致力于开拓DNA在纳米材料、传感、及生化特性方面的基础和应用研究,以合成DNA为单元构建了一系列精密可控的纳米机械装置并集成出微纳尺度上的“装配线”,证实了DNA在分子组装上的巨大潜力;围绕适配体构建变构型分子传感器,实现了对目标分子的快速精确检测,并发明了一种可用于AD临床早诊的探针;开发高效的试管内进化策略,筛选并发现具极强水解活性的DNA序列,揭示DNA鲜为人知的生化活性的同时,也为围绕DNA酶的生物技术应用打下了基础。多次在Nature、Nature Nanotech.、JACS、Anal. Chem.等顶级期刊上发表文章,并受邀为Chem. Rev.撰写主题述评。


国内外学术团体任职


受邀审稿学术刊物
2010-今        Nature Nanotechnology, Angewandte Chemie International Edition, Analytical Chemistry, Advanced Materials, ACS Nano, Bioconjugate Chemistry, ChemPhysChem, Nanotechnology, International Journal of Polymer Science, Biomaterials Science, Biochemistry, Scientific Reports, Nanoscale, Physics Biology

校内学术机构任职
学术委员会委员

受邀学术报告

(1) Gu Hongzhou, A Proximity-based DNA Nanoscale Assembly Line, the Foundations of Nanoscience 2011 Conference, Snowbird, Utah, 11-15 April 2011
(2) Gu Hongzhou, Small, Highly-active DNAs that Hydrolyze DNA, 2011 Yale RNA Club, New Haven, CT, 9 May 2011.
(3) Gu Hongzhou, A Proximity-based DNA Nanoscale Assembly Line, 2011 NSF Nanoscience Grantees Conference, Arlington, VA, 18-20 June 2011
(4) Gu Hongzhou, Engineered Allosteric Ribozymes for C-di-GMP Sensing, the 2012 International Conference on Riboregulation, Shanghai, China, 11-13 June 2012
(5) Gu Hongzhou, Small, Highly-active DNAs that Hydrolyze DNA, the Foundations of Nanoscience 2014 Conference, Snowbird, Utah, 15-19 April 2014
(6) Gu Hongzhou, Small, Highly-active DNAs that Hydrolyze DNA, the 6th International Conference on DNA Nanotechnology, Beijing, China, 26-28 August 2017

发表论文
1.Hu Qinqin, Li Hua, Wang Lihua, Gu Hongzhou*, Fan Chunhai*, DNA Nanotechnology Enabled Drug Delivery systems. Chemical Reviews 2018, doi: 10.1021/acs.chemrev.7b00663
2.Hu Qinqin, Wang Sheng, Wang Lihua, Gu Hongzhou*, Fan Chunhai*, DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides. Advanced Healthcare Materials, 2018, doi: 10.1002/adhm.201701153
3.Gu Hongzhou*, Single-molecule Genotyping with Nanoscale DNA Shape IDs. Science China Chemistry, 2017, 60, doi: 10.1007/s11426-017-9073-6.
4.Gu Hongzhou, Furukawa Kazuhiro,Weinberg Zasha, Berenson Daniel F., Breaker Ronald R.*, Small, Highly Active DNAs That Hydrolyze DNA,Journal of the American Chemical Society, 2013, 135(24): 9121-9129
5.Gu Hongzhou, Breaker Ronald R.*, Production of single-stranded DNAs by self-cleavage of rolling-circle amplification products, Biotechniques, 2013, 54(6): 337-340
6.Gu Hongzhou, Furukawa Kazuhiro, Breaker Ronald R.*, Engineered Allosteric Ribozymes That Sense the Bacterial Second Messenger Cyclic Diguanosyl 5 '-Monophosphate, Analytical Chemistry, 2012, 84(11): 4935-4941
7.Gu Hongzhou, Yang Wei, Seeman Nadrian C.*, DNA Scissors Device Used to Measure MutS Binding to DNA Mis-pairs, Journal of the American Chemical Society, 2010, 132(12): 4352-4357
8.Gu Hongzhou, Chao Jie, Xiao Shou-Jun, Seeman Nadrian C.*, A proximity-based programmable DNA nanoscale assembly line, Nature, 2010, 465(7295): 202-206
9.Gu Hongzhou, Chao Jie, Xiao Shou-Jun, Seeman Nadrian C.*, Dynamic patterning programmed by DNA tiles captured on a DNA origami substrate, Nature Nanotechnology, 2009, 4(4): 245-248

学术专著


申请或授权专利
授权专利

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申请专利
1.    Production of ss-DNAs by rolling circle amplification from templates encoding a self-cleaving deoxyribozyme,美国,专利号61/695,757,Hongzhou Gu & Ronald Breaker, Yale University
2.    一种检测硫胺素焦磷酸的RNA传感器及其应用,中国,专利号201810077122.9,顾宏周、杜鑫雨、钟春玖、程小芹

 

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