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教授
陈思锋
发表时间:2013-02-23 阅读次数:10454次

 

姓名:陈思锋
职称:教授
E-MAIL: chen1216@fudan.edu.cn
 

 

 

 

 

 

研究方向
1.血管内膜疾病的发生机制
2.心血管疾病的干细胞治疗基础
3.糖尿病及其并发症的免疫机制和免疫治疗
重要学术贡献
1.提出并证明干细胞控制细胞微环境和微环境控制干细胞决定干细胞不同分化命运的理论
2.提出并验证:选择性地持续提高病灶区域白介素-10可减轻器官移植排异和炎症性损伤的概念
3.提出并验证:特异性清除体内参与自身免疫反应的免疫细胞可预防和治疗自身免疫性疾病

荣誉与获奖
2016上海市教委:上海市全英语示范课程Pathophysiology
2006  波兰国家科技进步奖 (不分名次),波兰国家科技与教育部:国际合作研究血红素氧化酶-1在疾病中的作用。
1997  德国洪堡奖学金获得者(不分名次)
1997  国际癌症联盟技术转移奖(不分名次)。
1997  国家科技进步奖终审答辩(第一完成人): 急性肺损伤的发病机制
1995  军队科技进步二等奖(第一完成人):血小版活性因子和磷脂酶A2在急性肺损伤中的作用及机制
1995  军队三等功
1994  军队科技进步三等奖(第一完成人):白细胞-内皮细胞粘附对肺微血管内皮单层通透性的调节研究
1992  军队科技进步二等奖(第五完成人):急性肺损伤发生机理的实验研究
1991  军队科技进步三等奖(第三完成人):急性胰腺炎狗肺表面活性物质系统的损伤及机制研究
1990  军队科技进步三等奖(第一完成人):磷脂酶A2对灌流肺的损伤作用及机制探讨
1989  军队科技进步三等奖(第二完成人):狗急性胰腺炎所致肺损伤研究
1989  军队科技进步三等奖(第四完成人):犬急性出血性胰腺炎时II型肺泡上皮细胞板层体体视学研究

国内外学术团体任职
1.中国生理协会常务理事
2.中国病理生理协会常务理事
4.中国微循环协会常务理事
5.中国生理协会循环专业委员会副主任委员
6.中国病理生理协会微循环专业委员会副主任委员
7.上海生理科学会理事长
8.上海病理生理协会副理事长
9.中国病理生理协会动脉粥样硬化专业委员会、循环专业委员会、国际心脏协会中国分会等协会的理事

校内学术机构任职
1.复旦大学基础医学院生理与病理生理学系主任
2.复旦大学高血压与肾脏研究中心主任
3.复旦大学基础医学院学术委员会委员
4.复旦大学基础医学院聘任委员会委员

发表论文
1.Wang, Li,Xiang, Meng,Liu, Yingying,Sun, Ning,Lu, Meng,Shi, Yang,Wang, Xinhong,Meng, Dan,Chen, Sifeng*,Qin, Jianhua*,Human induced pluripotent stem cells derived endothelial cells mimicking vascular inflammatory response under flow.,Biomicrofluidics,2016.1.01,10(1):014106~014106
2.Kang, Xueling,Wei, Xiangxiang,Jiang, Li,Niu, Cong,Zhang, Jianyi,Chen, Sifeng*,Meng, Dan*,Nox2 and Nox4 regulate self-renewal of murine induced-pluripotent stem cells.,IUBMB Life,2016.12.01,68(12):963~970
3.Luan, Lijuan,Xue, Rong,Lu, Chao,Cui, Anfeng,Hou, Yanqiang,Quan, Jing,Xiang, Meng,Wang, Xinhong,Yuan, Wenjun,Sun, Ning,Meng, Dan*,Chen, Sifeng*,Anti-serum with anti-autoantibody activity decreases autoantibody-positive B lymphocytes and type 1 diabetes of female NOD mice,Autoimmunity,2016.1.2,49(1):21~30
4.Xie, Jingxin,Li, Xueyi,Meng, Dan,Liang, Qiujuan,Wang, Xinhong,Wang, Li,Wang, Rui,Xiang, Meng*,Chen, Sifeng*,Transduction of interleukin-10 through renal artery attenuates vascular neointimal proliferation and infiltration of immune cells in rat renal allograft.,Immunol Lett,2016.8.01,176:105~113
5.Jiang, Li,Yin, Meng,Wei, Xiangxiang,Liu, Junxu,Wang, Xinhong,Niu, Cong,Kang, Xueling,Xu, Jie,Zhou, Zhongwei,Sun, Shaoyang,Wang, Xu,Zheng, Xiaojun,Duan, Shengzhong,Yao, Kang,Qian, Ruizhe,Sun, Ning,Chen, Alex,Wang, Rui,Zhang, Jianyi,Chen, Sifeng*,Meng, Dan*,Bach1 Represses Wnt/beta-Catenin Signaling and Angiogenesis.,Circulation Research,2015.7.31,117(4):364~375
6.Liang, Qiu-Juan,Jiang, Mei,Wang, Xin-Hong,Le, Li-Li,Xiang, Meng,Sun, Ning,Meng, Dan*,Chen, Si-Feng*,Pre-existing interleukin 10 in cerebral arteries attenuates subsequent brain injury caused by ischemia/reperfusion,IUBMB Life,2015.9.01,67(9):710~719
7.Le, Li-Li,Li, Xue-Yi,Meng, Dan,Liang, Qiu-Jun,Wang, Xin-Hong,Li, Ning,Quan, Jing,Xiang, Meng,Jiang, Mei,Sun, Jian,Chen, Si-Feng*,Heme oxygenase-1 mediated memorial and revivable protective effect of ischemic preconditioning on brain injury.,CNS Neurosci Ther,2013.12.01,19(12):963~968
8.Wu, Yi(#),Zhang, Xueqing,Kang, Xueling,Li, Ning,Wang, Rong,Hu, Tiantian,Xiang, Meng,Wang, Xinhong,Yuan, Wenjun,Chen, Alex,Meng, Dan*,Chen, Sifeng*,Oxidative stress inhibits adhesion and transendothelial migration, and induces apoptosis and senescence of induced pluripotent stem cells.,Clin Exp Pharmacol Physiol,2013.9.01,40(9):626~634
9.江梅,全晶,张恒,丁倩倩,向萌,孟丹,孙宁,董强*,陈思锋*,动脉粥样硬化人群中血液外泌体的蛋白质谱分析,中国动脉硬化杂志,2016.9.26,(09):865~874
10.Xiang, Meng,Gu, Yiping,Zhao, Fengdi,Lu, Hong,Chen, Sifeng*,Yin, Lianhua*,Mast cell tryptase promotes breast cancer migration and invasion,Oncology Reports,2010.3.01,23(3):615~619
11.W.Zhang,X.Wang,H.Jin,R.Qian,G.Zhang,S.Chen*,R.Hu*,Effects of high glucose plus high insulin on proliferation and apoptosis of mouse endothelial progenitor cells,Inflammation Research,2008.12.01,57(12):571~576
12.Chen, B.,Kapturczak, M. H.,Joseph, R.,George, J. F.,Campbell-Thompson, M.,Wasserfall, C. H.,Atkinson, M. A.,Tisher, C. C.,Flotte, T. R.,Agarwal, A.,Chen, S.*,Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model,American Journal of Transplantation,2007.5.01,7(5):1112~1120
13.Chen, Sifeng*,Wasserfall, Clive,Kapturczak, Matthias H,Atkinson, Mark,Agarwal, Anupam,Freeze-thaw increases adeno-associated virus transduction of cells.,Am J Physiol Cell Physiol,2006.8.01,291(2):C386~C392
14.Chen, Sifeng,Kapturczak, Matthias H,Wasserfall, Clive,Glushakova, Olena Y,Campbell-Thompson, Martha,Deshane, Jessy S,Joseph, Reny,Cruz, Pedro E,Hauswirth, William W,Madsen, Kirsten M,Croker, Byron P,Berns, Kenneth I,Atkinson, Mark A,Flotte, Terence R,Tisher, C Craig,Agarwal, Anupam,Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway.,Proc Natl Acad Sci U S A,2005.5.17,102(20):7251~7256
15.Chen, Sifeng,Kapturczak, Matthias,Loiler, Scott A,Zolotukhin, Sergei,Glushakova, Olena Y,Madsen, Kirsten M,Samulski, Richard J,Hauswirth, William W,Campbell-Thompson, Martha,Berns, Kenneth I,Flotte, Terence R,Atkinson, Mark A,Tisher, C Craig,Agarwal, Anupam*,Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors.,Hum Gene Ther,2005.2.01,16(2):235~247
16.Chen, Sifeng,Sega, Mark,Agarwal, Anupam*,"Lumen digestion" technique for isolation of aortic endothelial cells from heme oxygenase-1 knockout mice.,Biotechniques,2004.7.01,37(1):84~6, 88-9
17.Chen, Sifeng,Agarwal, Anupam,Glushakova, Olena Y,Jorgensen, Marda S,Salgar, Shashikumar K,Poirier, Amy,Flotte, Terence R,Croker, Byron P,Madsen, Kirsten M,Atkinson, Mark A,Hauswirth, William W,Berns, Kenneth I,Tisher, C Craig*,Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors.,J Am Soc Nephrol,2003.4.01,14(4):947~958
18.Chen, Sifeng,Gomez, Sheilachu P,McCarley, Dean,Mainwaring, Mark G*,Topotecan-induced topoisomerase IIalpha expression increases the sensitivity of the CML cell line K562 to subsequent etoposide plus mitoxantrone treatment.,Cancer Chemother Pharmacol,2002.5.01,49(5):347~355
19.Chen, S,Patel, J M*,Block, E R,Angiotensin IV-mediated pulmonary artery vasorelaxation is due to endothelial intracellular calcium release.,Am J Physiol Lung Cell Mol Physiol,2000.11.01,279(5):L849~L856
20.Si-Feng Chen*,Xia Fei,Shao-Hua Li,A New Simple Method for Isolation of Microvascular Endothelial Cells Avoiding Both Chemical and Mechanical Injuries,Microvascular Research,1995.7.01,50(1):119~128
21.Chen Si-Feng*,1α,25-Dihydroxyvitamin D3 decreased ICAM-1 and ELAM-1 expressions on pulmonary microvascular endothelial cells and neutrophil motivation,The Journal of Steroid Biochemistry and Molecular Biology,1995.1.01,52(1):67~70
22.Chen S F*,Ruan, Y J,1 alpha,25-Dihydroxyvitamin D3 decreases scalding- and platelet-activating factor-induced high vascular permeability and tissue oedema.,Pharmacol Toxicol,1995.6.01,76(6):365~367
23.Chen, S F*,The effects of platelet activating factor and retinoic acid on the expression of ELAM-1 and ICAM-1 and the functions of neutrophils.,Mediators Inflamm,1995.01.01,4(2):103~106
24.陈思锋*,姜远英,张凤斋,朱铨英,钟纪根,张金山,萎胃安对大鼠慢性萎缩性胃炎的预防和治疗作用,药学实践杂志,1998.12.15,(06):328~330+353
25.陈思锋*,纪晓峰,李忆东,姜远英,血小板激活因子和维甲酸对中性粒细胞功能和ICAM-1,ELAM-1表达的影响,第二军医大学学报,1996.12.30,(06):518~522
26.陈思锋*,李少华,丁凤英,三种药物对磷脂酶A2所致内皮细胞单层通透性升高的抑制作用(英文),Acta Pharmacologica Sinica,1994.8.30,(04):13~16
27.陈思锋*,费侠,李少华,血小板激活因子所致的大鼠肺损伤依赖于细胞外钙离子的存在,第二军医大学学报,1993.8.29,(04):327~330
28.陈思锋*,张红红,李少华,丁自强,费侠,狗磷脂酶A2与白细胞活性的关系,基础医学与临床,1992.5.30,(05):24~27
29.陈思锋*,李少华,吴中立,费侠,张金山,用大鼠离体灌流肺测定肺血管通透性和血管阻力,中国应用生理学杂志,1991.7.2,(02):61~63
30.Chen, S F*,Li, S H,Fei, X,Wu, Z L,Phospholipase A2-induced lung edema and its mechanism in isolated perfused guinea pig lung,Inflammation,1990.6.01,14(3):267~273
31.陈思锋*,丁自强,吴中立,王琪,李少华,Phospholipase A2 and Its Relationship with Acute Lung Injury in Acute Pancreatitis in Dogs,Journal of Medical Colleges of PLA,1989.7.2,(02):129~134
32.陈思锋,吴中立,体液和组织磷脂酶A2简便快速测定法,第二军医大学学报,1989.6.30,(03):254~256
33.陈思锋*,吴中立,丁自强,王琪,李少华,狗急性胰腺炎时磷脂酶A2的变化及其在急性肺损伤中的作用,第二军医大学学报,1989.5.1,(02):105~195

学术专著
1. 副主编:《人体病理生理学》第3版,人民卫生出版社,300万字, 2018
2. 主编:《病理生理学》,复旦大学出版社,2015
3. 共同主编:《高级临床病理生理学》,复旦大学出版社,2010

申请或授权专利
授权专利

1.  胰岛素与血清蛋白可逆性结合的亲和力指标测定方法及应用,201110184366.5,陈思锋,陆超,栾丽娟,张雪晴,侯彦强,孟丹,李晓波,向萌,王丽,赵风娣

 

 

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