教授

张莹

博士生导师,上海市青年科技启明星,上海市浦江人才


主要研究领域:

       修饰蛋白质组生物质谱分析新方法及其在蛋白质组学中的应用研究。在基于生物质谱的蛋白质修饰研究新方法方面开展了长期系统的研究,创新地引入了多种类型的化学反应和小分子衍生方法提高糖蛋白质和糖链的富集效率及质谱分析能力,将糖蛋白质和糖链的富集选择性提高了1-2个数量级,检测灵敏度提高了2个数量级,实现了中性糖和唾液酸糖的同时准确定量和糖链同分异构体,触角结构、唾液酸个数的可靠解析和识别等;以及发展了病原菌表面糖蛋白等的活体标记方法用于追踪病原菌和宿主细胞感染过程动态相互作用。以第一和通讯作者发表包括Angew Chem Int Ed (Inside Cover),Nat Commun, ACS Nano (ESI高被引论文), Adv Func Mat, Chem Sci, Anal Chem和Chem Commun等在内的SCI论文30余篇。主持科技部重大科学仪器开发项目应用课题(课题组长,2013~2017)、国家自然科学基金面上项目(3项)、国家自然科学基金青年基金等科研项目,入选上海市浦江人才(2019),上海市青年科技启明星(2015)等人才计划。作为共同主编编写英文专著《Mass spectrometry-based Chemical Proteomics》(Wiley, 2019)。


联系方式:

电话:021-54237618

地址:上海市东安路131号明道楼311

邮箱:ying@fudan.edu.cn

 

代表性论文:

1、Ying Zhang*, Der-Shyang Kao, Bing Gu, Rajdeep Bomjan, Mayank Srivastava, Haojie Lu, Daoguo Zhou, W. Andy Tao* Tracking pathogen infection by time-resolved chemical proteomics Angew. Chem. Int. Ed., 2020, 59, 2235-2240. (Inside Cover)

2、Mayank Srivastava, Ying Zhang*, Jian Chen, Andrew Miller, Devika Sirohi, Yang Zhang, Haojie Lu, Jianqing Xu*, Richard J. Kuhn* and W. Andy Tao* Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor. Nat. Comm., 2020, 11, 3896

3、Lijun Yang, Zhengyu Sun, Lei Zhang, Ye Peng, Yan Cai, Ting Cao, Ying Zhang* and Haojie Lu* Chemical labeling for fine mapping of IgG N-glycosylation by ETD MS. Chem. Sci., 2019, 10, 9302-9307.

4、Lijun Yang, Xiaoxian Du, Ye Peng, Yan Cai, Lei Wei, Ying Zhang* and Haojie Lu* Integrated pipeline of isotopic labeling and selective enriching for quantitative analysis of N-Glycome by mass spectrometry. Anal. Chem., 2019, 91, 1486-1493.

5、Lei Wei, Yan Cai, Lijun Yang, Ying Zhang* and Haojie Lu* Duplex stable isotope labeling (DuSIL) for simultaneous quantitation and distinction of sialylated and neutral N-glycans by MALDI-MS. Anal. Chem., 2018, 90, 10442-10449.

6、Ying Zhang, Xiaofeng Wu, W. Andy Tao Characterization and applications of extracellular vesicle proteome with post-translational modifications. Trends Anal. Chem., 2018, 107, 21-30.

7、Ying Zhang, Lijun Yang, Ye Peng, Haojie Lu* Advances in sample preparation strategies for MS-based qualitative and quantitative N-Glycomics. Trends Anal. Chem., 2018, 99, 34-46.

8、Cheng Zhang, Tao Tao, Wenjuan Yuan, Lei Zhang, Xiaoqin Zhang, Jun Yao, Ying Zhang*, and Haojie Lu* Fluorous solid-phase extraction technique based on nanographite fluoride. Anal. Chem., 2017, 89, 4566–4572.

9、Ying Zhang, Chunzhao Zhao, Li Li, Chuan-Chih Hsu, Jian-Kang Zhu, Anton Iliuk*, and W. Andy Tao* High-throughput phosphorylation screening and validation through Ti(IV)-nanopolymer functionalized reverse phase phosphoprotein array. Anal. Chem., 2018, 90, 10263-10270.

10、Ying Zhang, Cheng Zhang, Hucong Jiang, Pengyuan Yang, Haojie Lu*. Fishing the PTM proteome with chemical approaches using functional solid phases. Chem. Soc. Rev., 2015, 44, 8260-8287.

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