教授

刘锋

刘锋(1972~),研究员,博导


个人简历:

       复旦大学博士。曾于国家人类基因组南方研究中心担任助理研究员、副研究员、研究员,现任复旦大学生物医学研究院研究员PI。主要研究领域:前期为功能基因组、寄生虫基因组、蛋白质组学研究,目前为肿瘤相关基因的分子机制、肿瘤标志物研究。代表性成果:发现和验证了8个新的人类分泌蛋白基因;通过日本血吸虫转录组研究及日本血吸虫的大规模蛋白质组学研究,全面系统地绘制了血吸虫不同性别和生活周期基因表达谱,为研究血吸虫生物学行为、致病机制、基因组结构和应用研究奠定基础;参与日本血吸虫基因组研究,揭示血吸虫的感受器、神经递质受体系统、内分泌系统受体及蛋白酶等方面的特征;主持建立日本血吸虫转录组和蛋白质整合数据库SjTPdb;发现参与血吸虫与宿主相互作用的关键分子;揭示重要抑癌基因ARID1A抑制胃癌细胞转移的分子机制。共发表SCI论文20篇,总引用>1100次;其中第一作者(含并列)、通讯作者论文共11篇(包括Nature、Nature genetics、PLoS Pathogens、Molecular and Cellular Proteomics等杂志)。获973、863、重大疾病专项、上海市项目共9项,共计科研经费783万元。获得上海市自然科学奖一等奖、第11届中国青年科技奖、上海市青年科技启明星、启明星跟踪计划、明治乳业生命科学奖最高奖—杰出奖等。


研究方向:
1. Molecular Oncology
2. Molecular marker of cancer
3. Functional genomics

 

代表性论文:

1. Qiao J, Cui SJ, Xu LL, Chen SJ, Yao J, Jiang YH, Peng G, Fang CY, Yang PY and Liu F*. Filamin C, a dysregulated protein in cancer revealed by label-free quantitative proteomic analyses of human gastric cancer cells. Oncotarget. 2014. In press.
2. Chen SX, Xu XE, Wang XQ, Cui SJ, Xu LL, Jiang YH, Zhang Y, Yan HB, Zhang Q, Qiao J, Yang PY and Liu F*. Identification of colonic fibroblast secretomes reveals secretory factors regulating colon cancer cell proliferation. Journal of Proteomics. 2014; 110:155-171.
3. Yan HB, Wang XF, Zhang Q, Tang ZQ, Jiang YH, Fan HZ, Sun YH, Yang PY and Liu F*. Reduced expression of the chromatin remodeling gene ARID1A enhances gastric cancer cell migration and invasion via downregulation of E-cadherin transcription. Carcinogenesis. 2014; 35(4):867-876.
4. Chen S-X, Xu X-E, Wang X-Q, Cui S-J, Xu L-L, Jiang Y-H, Zhang Y, Yan H-B, Zhang Q, Qiao J, Yang P-Y and Liu F*. Data from a proteomic analysis of colonic fibroblasts secretomes. Data in Brief. 2014; 1:19-24.
5. Cui SJ, Xu LL, Zhang T, Xu M, Yao J, Fang CY, Feng Z, Yang PY, Hu W and Liu F*. Proteomic characterization of larval and adult developmental stages in Echinococcus granulosus reveals novel insight into host-parasite interactions. J Proteomics. 2013; 84:158-175.
7. The Schistosoma japonicum Genome Sequencing and Functional Analysis Consortium, Liu F, Zhou Y, Wang ZQ, Lu G, Zheng H, Brindley PJ, McManus DP, Blair D, Zhang QH, Zhong Y, Wang S, Han ZG, Chen Z. The Schistosoma japonicum genome reveals features of host-parasite interplay. Nature. 2009; 460(7253):345-351.
8. Liu F, Cui SJ, Hu W, Feng Z, Wang ZQ and Han ZG. Excretory/secretory proteome of the adult developmental stage of human blood fluke, Schistosoma japonicum. Mol Cell Proteomics. 2009; 8(6):1236-1251.
9. Yu J, Liu F, Cui SJ, Liu Y, Song ZY, Cao H, Chen FE, Wang WJ, Sun T and Wang F. Vitreous proteomic analysis of proliferative vitreoretinopathy. Proteomics. 2008; 8(17):3667-3678. (Equal contribution)
10. Liu F*, Chen P, Cui SJ, Wang ZQ and Han ZG. SjTPdb: integrated transcriptome and proteome database and analysis platform for Schistosoma japonicum. BMC Genomics. 2008; 9:304.
11. Liu F, Hu W, Cui SJ, Chi M, Fang CY, Wang ZQ, Yang PY and Han ZG. Insight into the host-parasite interplay by proteomic study of host proteins copurified with the human parasite, Schistosoma japonicum. Proteomics. 2007; 7(3):450-462.
12. Liu F, Lu J, Hu W, Wang SY, Cui SJ, Chi M, Yan Q, Wang XR, Song HD, Xu XN, Wang JJ, Zhang XL, Zhang X, Wang ZQ, Xue CL, Brindley PJ, et al. New perspectives on host-parasite interplay by comparative transcriptomic and proteomic analyses of Schistosoma japonicum. PLoS Pathog. 2006; 2(4):e29.
13. Liu F, Lu J, Fan HH, Wang ZQ, Cui SJ, Zhang GA, Chi M, Zhang X, Yang PY, Chen Z and Han ZG. Insights into human CD34+ hematopoietic stem/progenitor cells through a systematically proteomic survey coupled with transcriptome. Proteomics. 2006; 6(9):2673-2692.
14. Hu W, Yan Q, Shen DK, Liu F, Zhu ZD, Song HD, Xu XR, Wang ZJ, Rong YP, Zeng LC, Wu J, Zhang X, Wang JJ, Xu XN, Wang SY, Fu G, et al. Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource. Nat Genet. 2003; 35(2):139-147. (Equal contribution)
15. Liu F, Rong YP, Zeng LC, Zhang X and Han ZG. Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein. Gene. 2003; 315:71-78.

 

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